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About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
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Tissue Distribution
Diseases
Cytomics
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FAQ
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FGB [extracellular region]
Stable Identifier
R-HSA-140584
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
extracellular region
Synonyms
fibrinogen beta chain
Locations in the PathwayBrowser
Expand all
Disease (Homo sapiens)
Diseases of signal transduction by growth factor receptors and second messengers (Homo sapiens)
Oncogenic MAPK signaling (Homo sapiens)
Paradoxical activation of RAF signaling by kinase inactive BRAF (Homo sapiens)
Activated MAP2Ks phosphorylate MAPKs downstream of inactive BRAF mutants (Homo sapiens)
RAS:GTP: inactive p-RAF:p-2S MAP2Ks:MAPKs:scaffold proteins [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
fibrin monomer [extracellular region] (Homo sapiens)
FGB [extracellular region] (Homo sapiens)
RAS:GTP:inactive p-RAF:p-2S MAP2Ks:p-T,Y MAPKs:scaffold proteins [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
fibrin monomer [extracellular region] (Homo sapiens)
FGB [extracellular region] (Homo sapiens)
Dissociation of paradoxically activated RAS:BRAF complexes (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
fibrin monomer [extracellular region] (Homo sapiens)
FGB [extracellular region] (Homo sapiens)
RAS:GTP:inactive p-RAF:p-2S MAP2Ks:p-T,Y MAPKs:scaffold proteins [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
fibrin monomer [extracellular region] (Homo sapiens)
FGB [extracellular region] (Homo sapiens)
RAS:GTP:inactive p-RAF complexes phosphorylate MAP2Ks (Homo sapiens)
RAS:GTP: inactive p-RAF:p-2S MAP2Ks:MAPKs:scaffold proteins [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
fibrin monomer [extracellular region] (Homo sapiens)
FGB [extracellular region] (Homo sapiens)
RAS:GTP:inactive p-RAF:MAP2Ks:MAPKs:scaffold proteins [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
fibrin monomer [extracellular region] (Homo sapiens)
FGB [extracellular region] (Homo sapiens)
RAS:GTP:p-RAF complexes paradoxically bind MAP2Ks and MAPKs (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
fibrin monomer [extracellular region] (Homo sapiens)
FGB [extracellular region] (Homo sapiens)
RAS:GTP:inactive p-RAF:MAP2Ks:MAPKs:scaffold proteins [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
fibrin monomer [extracellular region] (Homo sapiens)
FGB [extracellular region] (Homo sapiens)
Signaling by BRAF and RAF1 fusions (Homo sapiens)
Dissociation of BRAF/RAF fusion complex (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
fibrin monomer [extracellular region] (Homo sapiens)
FGB [extracellular region] (Homo sapiens)
p-BRAF/RAF fusion dimers:p-2S MAP2Ks:p-T,Y MAPKs:scaffold proteins [cytosol] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
fibrin monomer [extracellular region] (Homo sapiens)
FGB [extracellular region] (Homo sapiens)
MAPKs are phosphorylated downstream of BRAF and RAF fusion dimers (Homo sapiens)
p-BRAF/RAF fusion dimers:p-2S MAP2Ks:MAPKs:scaffold proteins [cytosol] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
fibrin monomer [extracellular region] (Homo sapiens)
FGB [extracellular region] (Homo sapiens)
p-BRAF/RAF fusion dimers:p-2S MAP2Ks:p-T,Y MAPKs:scaffold proteins [cytosol] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
fibrin monomer [extracellular region] (Homo sapiens)
FGB [extracellular region] (Homo sapiens)
p-BRAF and RAF fusion dimers bind MAP2Ks and MAPKs (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
fibrin monomer [extracellular region] (Homo sapiens)
FGB [extracellular region] (Homo sapiens)
p-BRAF/RAF fusion dimers:MAP2Ks:MAPKs:scaffold proteins [cytosol] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
fibrin monomer [extracellular region] (Homo sapiens)
FGB [extracellular region] (Homo sapiens)
p-BRAF and RAF fusion dimers phosphorylate MAP2Ks (Homo sapiens)
p-BRAF/RAF fusion dimers:MAP2Ks:MAPKs:scaffold proteins [cytosol] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
fibrin monomer [extracellular region] (Homo sapiens)
FGB [extracellular region] (Homo sapiens)
p-BRAF/RAF fusion dimers:p-2S MAP2Ks:MAPKs:scaffold proteins [cytosol] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
fibrin monomer [extracellular region] (Homo sapiens)
FGB [extracellular region] (Homo sapiens)
Signaling by RAF1 mutants (Homo sapiens)
Dissociation of RAS:RAF1 mutant complex (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
fibrin monomer [extracellular region] (Homo sapiens)
FGB [extracellular region] (Homo sapiens)
activated RAF1 mutant:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
fibrin monomer [extracellular region] (Homo sapiens)
FGB [extracellular region] (Homo sapiens)
MAP2Ks and MAPKs bind to the activated mutant RAF1 complex (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
fibrin monomer [extracellular region] (Homo sapiens)
FGB [extracellular region] (Homo sapiens)
activated RAF1 mutant:scaffold:MAP2K:MAPK complex [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
fibrin monomer [extracellular region] (Homo sapiens)
FGB [extracellular region] (Homo sapiens)
MAP2Ks phosphorylate MAPKs downstream of RAF1 mutants (Homo sapiens)
activated RAF1 mutant:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
fibrin monomer [extracellular region] (Homo sapiens)
FGB [extracellular region] (Homo sapiens)
activated RAF1 mutant:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
fibrin monomer [extracellular region] (Homo sapiens)
FGB [extracellular region] (Homo sapiens)
RAF1 mutant complexes phosphorylate MAP2K dimer (Homo sapiens)
activated RAF1 mutant:scaffold:MAP2K:MAPK complex [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
fibrin monomer [extracellular region] (Homo sapiens)
FGB [extracellular region] (Homo sapiens)
activated RAF1 mutant:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
fibrin monomer [extracellular region] (Homo sapiens)
FGB [extracellular region] (Homo sapiens)
Signaling by RAS mutants (Homo sapiens)
Signaling downstream of RAS mutants (Homo sapiens)
Activated MAP2Ks phosphorylate MAPKs downstream of oncogenic RAS (Homo sapiens)
mutant RAS:GTP:p-RAF:p-2S MAP2Ks:MAPKs:scaffold proteins [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
fibrin monomer [extracellular region] (Homo sapiens)
FGB [extracellular region] (Homo sapiens)
mutant RAS:GTP:p-RAF:p-2S MAP2Ks:p-T,Y MAPKs:scaffold proteins [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
fibrin monomer [extracellular region] (Homo sapiens)
FGB [extracellular region] (Homo sapiens)
Dissociation of oncogenic RAS:RAF complex (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
fibrin monomer [extracellular region] (Homo sapiens)
FGB [extracellular region] (Homo sapiens)
mutant RAS:GTP:p-RAF:p-2S MAP2Ks:p-T,Y MAPKs:scaffold proteins [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
fibrin monomer [extracellular region] (Homo sapiens)
FGB [extracellular region] (Homo sapiens)
Mutant RAS:p-RAF complexes bind MAP2Ks and MAPKs (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
fibrin monomer [extracellular region] (Homo sapiens)
FGB [extracellular region] (Homo sapiens)
mutant RAS:GTP:p-RAF:MAP2Ks:MAPKs:scaffold proteins [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
fibrin monomer [extracellular region] (Homo sapiens)
FGB [extracellular region] (Homo sapiens)
Mutant RAS:p-RAF complexes phosphorylate MAP2Ks (Homo sapiens)
mutant RAS:GTP:p-RAF:MAP2Ks:MAPKs:scaffold proteins [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
fibrin monomer [extracellular region] (Homo sapiens)
FGB [extracellular region] (Homo sapiens)
mutant RAS:GTP:p-RAF:p-2S MAP2Ks:MAPKs:scaffold proteins [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
fibrin monomer [extracellular region] (Homo sapiens)
FGB [extracellular region] (Homo sapiens)
Signaling by high-kinase activity BRAF mutants (Homo sapiens)
Activated MAP2Ks phosphorylate MAPKs downstream of high kinase activity BRAF mutants (Homo sapiens)
high kinase activity BRAF mutants:scaffold:p-2S MAP2K:MAPK complex [cytosol] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
fibrin monomer [extracellular region] (Homo sapiens)
FGB [extracellular region] (Homo sapiens)
high kinase activity BRAF mutants:scaffold:p-2S MAP2K:p-T,Y MAPK complex [cytosol] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
fibrin monomer [extracellular region] (Homo sapiens)
FGB [extracellular region] (Homo sapiens)
Dissociation of high activity BRAF complexes (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
fibrin monomer [extracellular region] (Homo sapiens)
FGB [extracellular region] (Homo sapiens)
high kinase activity BRAF mutants:scaffold:p-2S MAP2K:p-T,Y MAPK complex [cytosol] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
fibrin monomer [extracellular region] (Homo sapiens)
FGB [extracellular region] (Homo sapiens)
High kinase activity BRAF complexes phosphorylate MAP2Ks (Homo sapiens)
high kinase activity BRAF mutants:scaffold:MAP2K:MAPK complex [cytosol] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
fibrin monomer [extracellular region] (Homo sapiens)
FGB [extracellular region] (Homo sapiens)
high kinase activity BRAF mutants:scaffold:p-2S MAP2K:MAPK complex [cytosol] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
fibrin monomer [extracellular region] (Homo sapiens)
FGB [extracellular region] (Homo sapiens)
High kinase activity BRAF mutants bind MAP2Ks and MAPKs (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
fibrin monomer [extracellular region] (Homo sapiens)
FGB [extracellular region] (Homo sapiens)
high kinase activity BRAF mutants:scaffold:MAP2K:MAPK complex [cytosol] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
fibrin monomer [extracellular region] (Homo sapiens)
FGB [extracellular region] (Homo sapiens)
Signaling by moderate kinase activity BRAF mutants (Homo sapiens)
Activated MAP2Ks phosphorylate MAPKs downstream of moderate kinase activity BRAF mutants (Homo sapiens)
RAS:GTP:moderate kinase activity p-RAF:p-2S MAP2Ks:MAPKs:scaffold proteins [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
fibrin monomer [extracellular region] (Homo sapiens)
FGB [extracellular region] (Homo sapiens)
RAS:GTP:moderate kinase activity p-RAF:p-2S MAP2Ks:p-T,Y MAPKs:scaffold proteins [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
fibrin monomer [extracellular region] (Homo sapiens)
FGB [extracellular region] (Homo sapiens)
Dissociation of moderate activity BRAF complexes (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
fibrin monomer [extracellular region] (Homo sapiens)
FGB [extracellular region] (Homo sapiens)
RAS:GTP:moderate kinase activity p-RAF:p-2S MAP2Ks:p-T,Y MAPKs:scaffold proteins [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
fibrin monomer [extracellular region] (Homo sapiens)
FGB [extracellular region] (Homo sapiens)
RAS:GTP:moderate kinase activity p-RAF complexes bind MAP2Ks and MAPKs (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
fibrin monomer [extracellular region] (Homo sapiens)
FGB [extracellular region] (Homo sapiens)
RAS:GTP:moderate kinase activity p-RAF:MAP2Ks:MAPKs:scaffold proteins [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
fibrin monomer [extracellular region] (Homo sapiens)
FGB [extracellular region] (Homo sapiens)
RAS:GTP:moderate kinase activity p-RAF complexes phosphorylate MAP2Ks (Homo sapiens)
RAS:GTP:moderate kinase activity p-RAF:MAP2Ks:MAPKs:scaffold proteins [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
fibrin monomer [extracellular region] (Homo sapiens)
FGB [extracellular region] (Homo sapiens)
RAS:GTP:moderate kinase activity p-RAF:p-2S MAP2Ks:MAPKs:scaffold proteins [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
fibrin monomer [extracellular region] (Homo sapiens)
FGB [extracellular region] (Homo sapiens)
Extracellular matrix organization (Homo sapiens)
Integrin cell surface interactions (Homo sapiens)
Adhesion of integrin αIIbβ3 to fibrin network (Homo sapiens)
fibrin multimer [extracellular region] (Homo sapiens)
fibrin monomer [extracellular region] (Homo sapiens)
FGB [extracellular region] (Homo sapiens)
Interaction of integrin alphaDbeta2 with fibrin (Homo sapiens)
Integrin alphaDbeta2:fibrin multimer:Mg++ [plasma membrane] (Homo sapiens)
fibrin multimer [extracellular region] (Homo sapiens)
fibrin monomer [extracellular region] (Homo sapiens)
FGB [extracellular region] (Homo sapiens)
fibrin multimer [extracellular region] (Homo sapiens)
fibrin monomer [extracellular region] (Homo sapiens)
FGB [extracellular region] (Homo sapiens)
Interaction of integrin alphaXbeta2 with fibrin (Homo sapiens)
Integrin alphaXbeta2:fibrin multimer [plasma membrane] (Homo sapiens)
fibrin multimer [extracellular region] (Homo sapiens)
fibrin monomer [extracellular region] (Homo sapiens)
FGB [extracellular region] (Homo sapiens)
fibrin multimer [extracellular region] (Homo sapiens)
fibrin monomer [extracellular region] (Homo sapiens)
FGB [extracellular region] (Homo sapiens)
Hemostasis (Homo sapiens)
Formation of Fibrin Clot (Clotting Cascade) (Homo sapiens)
Common Pathway of Fibrin Clot Formation (Homo sapiens)
factor XIII -> factor XIII cleaved tetramer + 2 factor XIII A activation peptides (Homo sapiens)
fibrin multimer [extracellular region] (Homo sapiens)
fibrin monomer [extracellular region] (Homo sapiens)
FGB [extracellular region] (Homo sapiens)
fibrin multimer -> fibrin multimer, crosslinked + NH4+ (Homo sapiens)
fibrin multimer [extracellular region] (Homo sapiens)
fibrin monomer [extracellular region] (Homo sapiens)
FGB [extracellular region] (Homo sapiens)
fibrinogen -> fibrin monomer + 2 fibrinopeptide A + 2 fibrinopeptide B (Homo sapiens)
fibrin monomer [extracellular region] (Homo sapiens)
FGB [extracellular region] (Homo sapiens)
n fibrin monomers -> fibrin multimer (Homo sapiens)
fibrin monomer [extracellular region] (Homo sapiens)
FGB [extracellular region] (Homo sapiens)
fibrin multimer [extracellular region] (Homo sapiens)
fibrin monomer [extracellular region] (Homo sapiens)
FGB [extracellular region] (Homo sapiens)
Platelet activation, signaling and aggregation (Homo sapiens)
Platelet Aggregation (Plug Formation) (Homo sapiens)
Integrin signaling (Homo sapiens)
Autophosphorylation of PTK2 at Y397 (Homo sapiens)
Talin:RIAM complex: ECM ligands:Integrin alphaIIb beta3:Active (p-Y419)- SRC:PTK2 [plasma membrane] (Homo sapiens)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
fibrin monomer [extracellular region] (Homo sapiens)
FGB [extracellular region] (Homo sapiens)
Talin:RIAM complex:ECM ligands: alphaIIb beta3:Active p-Y419-SRC:pY397-PTK2 [plasma membrane] (Homo sapiens)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
fibrin monomer [extracellular region] (Homo sapiens)
FGB [extracellular region] (Homo sapiens)
Autophosphorylation of SRC (Homo sapiens)
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:SRC) [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
fibrin monomer [extracellular region] (Homo sapiens)
FGB [extracellular region] (Homo sapiens)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
fibrin monomer [extracellular region] (Homo sapiens)
FGB [extracellular region] (Homo sapiens)
Clustering of Integrin alphaIIb beta3 complexes (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
fibrin monomer [extracellular region] (Homo sapiens)
FGB [extracellular region] (Homo sapiens)
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:p(Y530)-SRC:CSK) [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
fibrin monomer [extracellular region] (Homo sapiens)
FGB [extracellular region] (Homo sapiens)
Dephosphorylation of inactive SRC by PTPB1 (Homo sapiens)
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:Inactive (p-Y530)-SRC) [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
fibrin monomer [extracellular region] (Homo sapiens)
FGB [extracellular region] (Homo sapiens)
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:SRC) [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
fibrin monomer [extracellular region] (Homo sapiens)
FGB [extracellular region] (Homo sapiens)
GRB2:SOS provides linkage to MAPK signaling for Integrins (Homo sapiens)
Interaction of SOS with GRB2 bound to FADK1 (Homo sapiens)
GRB2 bound to pPTK2 in Focal adhesion [plasma membrane] (Homo sapiens)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Homo sapiens)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
fibrin monomer [extracellular region] (Homo sapiens)
FGB [extracellular region] (Homo sapiens)
GRB2:SOS:p-PTK2:Focal adhesion [plasma membrane] (Homo sapiens)
GRB2 bound to pPTK2 in Focal adhesion [plasma membrane] (Homo sapiens)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Homo sapiens)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
fibrin monomer [extracellular region] (Homo sapiens)
FGB [extracellular region] (Homo sapiens)
Recruitment of GRB2 to p-PTK2 (Homo sapiens)
GRB2 bound to pPTK2 in Focal adhesion [plasma membrane] (Homo sapiens)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Homo sapiens)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
fibrin monomer [extracellular region] (Homo sapiens)
FGB [extracellular region] (Homo sapiens)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Homo sapiens)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
fibrin monomer [extracellular region] (Homo sapiens)
FGB [extracellular region] (Homo sapiens)
Interaction of integrin alphaIIb beta3 with Fibrinogen (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
fibrin monomer [extracellular region] (Homo sapiens)
FGB [extracellular region] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
fibrin monomer [extracellular region] (Homo sapiens)
FGB [extracellular region] (Homo sapiens)
Phosphorylation of pPTK2 by SRC (Homo sapiens)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Homo sapiens)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
fibrin monomer [extracellular region] (Homo sapiens)
FGB [extracellular region] (Homo sapiens)
Talin:RIAM complex:ECM ligands: alphaIIb beta3:Active p-Y419-SRC:pY397-PTK2 [plasma membrane] (Homo sapiens)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
fibrin monomer [extracellular region] (Homo sapiens)
FGB [extracellular region] (Homo sapiens)
Release of CSK from SRC (Homo sapiens)
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:Inactive (p-Y530)-SRC) [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
fibrin monomer [extracellular region] (Homo sapiens)
FGB [extracellular region] (Homo sapiens)
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:p(Y530)-SRC:CSK) [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
fibrin monomer [extracellular region] (Homo sapiens)
FGB [extracellular region] (Homo sapiens)
SYK activation by SRC (Homo sapiens)
Talin:RIAM:ECM ligands:2X (Integrin alphaIIb beta3:Active (p-Y419)-SRC):SYK [plasma membrane] (Homo sapiens)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
fibrin monomer [extracellular region] (Homo sapiens)
FGB [extracellular region] (Homo sapiens)
Talin:RIAM:ECM ligands:2X(Integrin alphaIIb beta3:Active (p-Y419)-SRC):p(Y)-SYK [plasma membrane] (Homo sapiens)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
fibrin monomer [extracellular region] (Homo sapiens)
FGB [extracellular region] (Homo sapiens)
SYK binds to integrin alphaIIb beta3 (Homo sapiens)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
fibrin monomer [extracellular region] (Homo sapiens)
FGB [extracellular region] (Homo sapiens)
Talin:RIAM:ECM ligands:2X (Integrin alphaIIb beta3:Active (p-Y419)-SRC):SYK [plasma membrane] (Homo sapiens)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
fibrin monomer [extracellular region] (Homo sapiens)
FGB [extracellular region] (Homo sapiens)
Translocation of PTK2 to Focal complexes (Homo sapiens)
Talin:RIAM complex: ECM ligands:Integrin alphaIIb beta3:Active (p-Y419)- SRC:PTK2 [plasma membrane] (Homo sapiens)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
fibrin monomer [extracellular region] (Homo sapiens)
FGB [extracellular region] (Homo sapiens)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
fibrin monomer [extracellular region] (Homo sapiens)
FGB [extracellular region] (Homo sapiens)
p130Cas linkage to MAPK signaling for integrins (Homo sapiens)
Crk binding to p130cas (Homo sapiens)
CRK:p-BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Homo sapiens)
p-BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Homo sapiens)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Homo sapiens)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
fibrin monomer [extracellular region] (Homo sapiens)
FGB [extracellular region] (Homo sapiens)
p-BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Homo sapiens)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Homo sapiens)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
fibrin monomer [extracellular region] (Homo sapiens)
FGB [extracellular region] (Homo sapiens)
Phosphorylation of BCAR1 by SRC-PTK2 complex (Homo sapiens)
BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Homo sapiens)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Homo sapiens)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
fibrin monomer [extracellular region] (Homo sapiens)
FGB [extracellular region] (Homo sapiens)
p-BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Homo sapiens)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Homo sapiens)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
fibrin monomer [extracellular region] (Homo sapiens)
FGB [extracellular region] (Homo sapiens)
Recruitment of BCAR1 to PTK2 complex (Homo sapiens)
BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Homo sapiens)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Homo sapiens)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
fibrin monomer [extracellular region] (Homo sapiens)
FGB [extracellular region] (Homo sapiens)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Homo sapiens)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
fibrin monomer [extracellular region] (Homo sapiens)
FGB [extracellular region] (Homo sapiens)
Signal Transduction (Homo sapiens)
Integrin signaling (Homo sapiens)
Autophosphorylation of PTK2 at Y397 (Homo sapiens)
Talin:RIAM complex: ECM ligands:Integrin alphaIIb beta3:Active (p-Y419)- SRC:PTK2 [plasma membrane] (Homo sapiens)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
fibrin monomer [extracellular region] (Homo sapiens)
FGB [extracellular region] (Homo sapiens)
Talin:RIAM complex:ECM ligands: alphaIIb beta3:Active p-Y419-SRC:pY397-PTK2 [plasma membrane] (Homo sapiens)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
fibrin monomer [extracellular region] (Homo sapiens)
FGB [extracellular region] (Homo sapiens)
Autophosphorylation of SRC (Homo sapiens)
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:SRC) [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
fibrin monomer [extracellular region] (Homo sapiens)
FGB [extracellular region] (Homo sapiens)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
fibrin monomer [extracellular region] (Homo sapiens)
FGB [extracellular region] (Homo sapiens)
Clustering of Integrin alphaIIb beta3 complexes (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
fibrin monomer [extracellular region] (Homo sapiens)
FGB [extracellular region] (Homo sapiens)
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:p(Y530)-SRC:CSK) [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
fibrin monomer [extracellular region] (Homo sapiens)
FGB [extracellular region] (Homo sapiens)
Dephosphorylation of inactive SRC by PTPB1 (Homo sapiens)
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:Inactive (p-Y530)-SRC) [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
fibrin monomer [extracellular region] (Homo sapiens)
FGB [extracellular region] (Homo sapiens)
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:SRC) [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
fibrin monomer [extracellular region] (Homo sapiens)
FGB [extracellular region] (Homo sapiens)
GRB2:SOS provides linkage to MAPK signaling for Integrins (Homo sapiens)
Interaction of SOS with GRB2 bound to FADK1 (Homo sapiens)
GRB2 bound to pPTK2 in Focal adhesion [plasma membrane] (Homo sapiens)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Homo sapiens)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
fibrin monomer [extracellular region] (Homo sapiens)
FGB [extracellular region] (Homo sapiens)
GRB2:SOS:p-PTK2:Focal adhesion [plasma membrane] (Homo sapiens)
GRB2 bound to pPTK2 in Focal adhesion [plasma membrane] (Homo sapiens)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Homo sapiens)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
fibrin monomer [extracellular region] (Homo sapiens)
FGB [extracellular region] (Homo sapiens)
Recruitment of GRB2 to p-PTK2 (Homo sapiens)
GRB2 bound to pPTK2 in Focal adhesion [plasma membrane] (Homo sapiens)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Homo sapiens)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
fibrin monomer [extracellular region] (Homo sapiens)
FGB [extracellular region] (Homo sapiens)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Homo sapiens)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
fibrin monomer [extracellular region] (Homo sapiens)
FGB [extracellular region] (Homo sapiens)
Interaction of integrin alphaIIb beta3 with Fibrinogen (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
fibrin monomer [extracellular region] (Homo sapiens)
FGB [extracellular region] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
fibrin monomer [extracellular region] (Homo sapiens)
FGB [extracellular region] (Homo sapiens)
Phosphorylation of pPTK2 by SRC (Homo sapiens)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Homo sapiens)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
fibrin monomer [extracellular region] (Homo sapiens)
FGB [extracellular region] (Homo sapiens)
Talin:RIAM complex:ECM ligands: alphaIIb beta3:Active p-Y419-SRC:pY397-PTK2 [plasma membrane] (Homo sapiens)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
fibrin monomer [extracellular region] (Homo sapiens)
FGB [extracellular region] (Homo sapiens)
Release of CSK from SRC (Homo sapiens)
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:Inactive (p-Y530)-SRC) [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
fibrin monomer [extracellular region] (Homo sapiens)
FGB [extracellular region] (Homo sapiens)
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:p(Y530)-SRC:CSK) [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
fibrin monomer [extracellular region] (Homo sapiens)
FGB [extracellular region] (Homo sapiens)
SYK activation by SRC (Homo sapiens)
Talin:RIAM:ECM ligands:2X (Integrin alphaIIb beta3:Active (p-Y419)-SRC):SYK [plasma membrane] (Homo sapiens)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
fibrin monomer [extracellular region] (Homo sapiens)
FGB [extracellular region] (Homo sapiens)
Talin:RIAM:ECM ligands:2X(Integrin alphaIIb beta3:Active (p-Y419)-SRC):p(Y)-SYK [plasma membrane] (Homo sapiens)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
fibrin monomer [extracellular region] (Homo sapiens)
FGB [extracellular region] (Homo sapiens)
SYK binds to integrin alphaIIb beta3 (Homo sapiens)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
fibrin monomer [extracellular region] (Homo sapiens)
FGB [extracellular region] (Homo sapiens)
Talin:RIAM:ECM ligands:2X (Integrin alphaIIb beta3:Active (p-Y419)-SRC):SYK [plasma membrane] (Homo sapiens)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
fibrin monomer [extracellular region] (Homo sapiens)
FGB [extracellular region] (Homo sapiens)
Translocation of PTK2 to Focal complexes (Homo sapiens)
Talin:RIAM complex: ECM ligands:Integrin alphaIIb beta3:Active (p-Y419)- SRC:PTK2 [plasma membrane] (Homo sapiens)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
fibrin monomer [extracellular region] (Homo sapiens)
FGB [extracellular region] (Homo sapiens)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
fibrin monomer [extracellular region] (Homo sapiens)
FGB [extracellular region] (Homo sapiens)
p130Cas linkage to MAPK signaling for integrins (Homo sapiens)
Crk binding to p130cas (Homo sapiens)
CRK:p-BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Homo sapiens)
p-BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Homo sapiens)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Homo sapiens)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
fibrin monomer [extracellular region] (Homo sapiens)
FGB [extracellular region] (Homo sapiens)
p-BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Homo sapiens)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Homo sapiens)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
fibrin monomer [extracellular region] (Homo sapiens)
FGB [extracellular region] (Homo sapiens)
Phosphorylation of BCAR1 by SRC-PTK2 complex (Homo sapiens)
BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Homo sapiens)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Homo sapiens)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
fibrin monomer [extracellular region] (Homo sapiens)
FGB [extracellular region] (Homo sapiens)
p-BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Homo sapiens)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Homo sapiens)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
fibrin monomer [extracellular region] (Homo sapiens)
FGB [extracellular region] (Homo sapiens)
Recruitment of BCAR1 to PTK2 complex (Homo sapiens)
BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Homo sapiens)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Homo sapiens)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
fibrin monomer [extracellular region] (Homo sapiens)
FGB [extracellular region] (Homo sapiens)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Homo sapiens)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
fibrin monomer [extracellular region] (Homo sapiens)
FGB [extracellular region] (Homo sapiens)
MAPK family signaling cascades (Homo sapiens)
MAPK1/MAPK3 signaling (Homo sapiens)
RAF/MAP kinase cascade (Homo sapiens)
MAP2K and MAPK activation (Homo sapiens)
Dissociation of RAS:RAF complex (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
fibrin monomer [extracellular region] (Homo sapiens)
FGB [extracellular region] (Homo sapiens)
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
fibrin monomer [extracellular region] (Homo sapiens)
FGB [extracellular region] (Homo sapiens)
Dual mechanism MAP2K inhibitors bind MAP2Ks (Homo sapiens)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
fibrin monomer [extracellular region] (Homo sapiens)
FGB [extracellular region] (Homo sapiens)
activated RAF:scaffold:MAP2K:MAPK complex:dual mechanism MAP2K inhibitors [plasma membrane] (Homo sapiens)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
fibrin monomer [extracellular region] (Homo sapiens)
FGB [extracellular region] (Homo sapiens)
Dual mechanism MAPK inhibitors bind MAPKs (Homo sapiens)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
fibrin monomer [extracellular region] (Homo sapiens)
FGB [extracellular region] (Homo sapiens)
activated RAF:scaffold:p-2S MAP2K:MAPK:dual mechanism MAPK inhibitors [plasma membrane] (Homo sapiens)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
fibrin monomer [extracellular region] (Homo sapiens)
FGB [extracellular region] (Homo sapiens)
MAP2Ks and MAPKs bind to the activated RAF complex (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
fibrin monomer [extracellular region] (Homo sapiens)
FGB [extracellular region] (Homo sapiens)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
fibrin monomer [extracellular region] (Homo sapiens)
FGB [extracellular region] (Homo sapiens)
MAP2Ks phosphorylate MAPKs (Homo sapiens)
activated RAF:scaffold:MAP2K:MAPK complex:dual mechanism MAP2K inhibitors [plasma membrane] (Homo sapiens)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
fibrin monomer [extracellular region] (Homo sapiens)
FGB [extracellular region] (Homo sapiens)
activated RAF:scaffold:p-2S MAP2K:MAPK:single mechanism MAP2K inhibitors [plasma membrane] (Homo sapiens)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
fibrin monomer [extracellular region] (Homo sapiens)
FGB [extracellular region] (Homo sapiens)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
fibrin monomer [extracellular region] (Homo sapiens)
FGB [extracellular region] (Homo sapiens)
activated RAF:scaffold:p-2S MAP2K:MAPK:dual mechanism MAPK inhibitors [plasma membrane] (Homo sapiens)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
fibrin monomer [extracellular region] (Homo sapiens)
FGB [extracellular region] (Homo sapiens)
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
fibrin monomer [extracellular region] (Homo sapiens)
FGB [extracellular region] (Homo sapiens)
RAF phosphorylates MAP2K dimer (Homo sapiens)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
fibrin monomer [extracellular region] (Homo sapiens)
FGB [extracellular region] (Homo sapiens)
activated RAF:scaffold:MAP2K:MAPK complex:dual mechanism MAP2K inhibitors [plasma membrane] (Homo sapiens)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
fibrin monomer [extracellular region] (Homo sapiens)
FGB [extracellular region] (Homo sapiens)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
fibrin monomer [extracellular region] (Homo sapiens)
FGB [extracellular region] (Homo sapiens)
Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks (Homo sapiens)
activated RAF:scaffold:p-2S MAP2K:MAPK:single mechanism MAP2K inhibitors [plasma membrane] (Homo sapiens)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
fibrin monomer [extracellular region] (Homo sapiens)
FGB [extracellular region] (Homo sapiens)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
fibrin monomer [extracellular region] (Homo sapiens)
FGB [extracellular region] (Homo sapiens)
Single mechanism MAPK inhibitors bind phosphorylated MAPK (Homo sapiens)
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
fibrin monomer [extracellular region] (Homo sapiens)
FGB [extracellular region] (Homo sapiens)
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK:single mechanism MAPK inhibitors [plasma membrane] (Homo sapiens)
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
fibrin monomer [extracellular region] (Homo sapiens)
FGB [extracellular region] (Homo sapiens)
External Reference Information
External Reference
UniProt:P02675 FGB
Gene Names
FGB
Chain
signal peptide:1-30, peptide:31-44, chain:45-491
Reference Genes
BioGPS Gene:2244 FGB
COSMIC (genes):FGB FGB
CTD Gene:2244 FGB
dbSNP Gene:2244 FGB
ENSEMBL:ENSG00000171564 FGB
HGNC:3662 FGB
KEGG:hsa:2244 FGB
Monarch:2244 FGB
NCBI Gene:2244 FGB
OMIM:134830 FGB
UCSC:P02675 FGB
Reference Transcript
RefSeq:NM_001184741.1 FGB
RefSeq:NM_005141.4 FGB
Other Identifiers
11715628_a_at
11746819_a_at
11755934_x_at
11758728_at
16971643
204988_PM_at
204988_at
216238_PM_s_at
216238_s_at
2244
2748550
2748552
2748553
2748554
2748555
2748556
2748557
2748558
2748559
2748560
2748561
2748562
2748563
2748564
2748565
2748566
2748567
2748568
2748569
2748570
37019_at
47589_at
63760_at
78341_at
8097910
A_14_P100691
A_23_P136125
GE62817
GO:0002250
GO:0002376
GO:0003013
GO:0005102
GO:0005198
GO:0005201
GO:0005515
GO:0005576
GO:0005577
GO:0005615
GO:0005783
GO:0005886
GO:0005938
GO:0007155
GO:0007160
GO:0007596
GO:0009897
GO:0009986
GO:0030168
GO:0030312
GO:0031012
GO:0031091
GO:0031093
GO:0031410
GO:0031639
GO:0034116
GO:0042730
GO:0043152
GO:0043226
GO:0044320
GO:0045087
GO:0045202
GO:0045907
GO:0045921
GO:0050714
GO:0050839
GO:0051087
GO:0051258
GO:0051592
GO:0051604
GO:0062023
GO:0065003
GO:0070062
GO:0070374
GO:0070527
GO:0071347
GO:0072378
GO:0072562
GO:0090277
GO:0098542
GO:1900026
GO:1902042
GO:1903561
GO:2000352
HMNXSV003033495
Hs.7645.1.S1_3p_a_at
Hs.7645.1.S1_3p_x_at
ILMN_1678049
ILMN_2114972
J00129_at
PH_hs_0023603
TC04000777.hg
g11761630_3p_at
Participates
as a component of
fibrin monomer [extracellular region] (Homo sapiens)
Other forms of this molecule
FGB(31-44) [extracellular region]
FGB [plasma membrane]
FGB(31-491) [extracellular region]
FGB(31-491) [platelet alpha granule lumen]
Inferred To
FGB [extracellular region]
(Gallus gallus)
FGB [extracellular region]
(Sus scrofa)
Fgb [extracellular region]
(Mus musculus)
Fgb [extracellular region]
(Rattus norvegicus)
Cross References
RefSeq
NP_005132.2
,
NP_001171670.1
OpenTargets
ENSG00000171564
ENSEMBL
ENSP00000306099
,
ENSG00000171564
,
ENST00000302068
GeneCards
FGB
HPA
ENSG00000171564-FGB
PRO
P02675
Pharos - Targets
P02675
GlyGen
P02675
Orphanet
FGB
HMDB Protein
HMDBP13514
PDB
3GHG
,
2Z4E
,
2XNX
,
3E1I
,
2XNY
,
2H43
,
2HOD
,
1RE4
,
2A45
,
2OYH
,
2FFD
,
1RF0
,
2OYI
,
1RF1
,
1N8E
,
2HPC
,
3HUS
,
2Q9I
,
1RE3
,
3H32
,
1N86
,
1FZA
,
1FZC
,
1FZB
,
2HLO
,
6BIJ
,
6BIL
,
6V18
,
6V19
,
6V0Y
,
6V15
,
6V13
,
3BVH
,
1LTJ
,
1FZF
,
1FZG
,
1FZE
,
6ATZ
,
6V1A
,
1LT9
Interactors (53)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P02671 FGA
8
FGA [extracellular region]
(R-HSA-140583)
FGA(20-35) [extracellular region]
(R-HSA-140867)
FGA [plasma membrane]
(R-HSA-140916)
FGA(20-866) [extracellular region]
(R-HSA-140841)
FGA(20-866) [platelet alpha granule lumen]
(R-HSA-140920)
FGA [endoplasmic reticulum lumen]
(R-HSA-8956714)
p-FGA [endoplasmic reticulum lumen]
(R-HSA-8957043)
Variant fibrinogen alpha chain [extracellular region]
(R-HSA-976905)
0.852
11
UniProt:P27958-PRO_0000037566
0.543
4
UniProt:Q9GZZ1 NAA50
0.527
2
UniProt:Q9H993 ARMT1
0.527
2
UniProt:Q05639 EEF1A2
1
EEF1A2 [cytosol]
(R-HSA-3907261)
0.527
2
UniProt:Q9NQG5 RPRD1B
1
RPRD1B [nucleoplasm]
(R-HSA-6814894)
0.527
2
UniProt:Q9UNH7 SNX6
0.527
2
UniProt:O95747 OXSR1
0.527
2
UniProt:Q08752 PPID
1
PPID [nucleoplasm]
(R-HSA-8939168)
0.527
2
UniProt:Q9C0B1 FTO
1
FTO [nucleoplasm]
(R-HSA-8857715)
0.527
2
UniProt:Q96KB5 TOPK
0.527
2
UniProt:O43252 PAPSS1
3
PAPSS1 [cytosol]
(R-HSA-174387)
PAPSS1(1-223)-BRAF(381-766) fusion [cytosol]
(R-HSA-6802432)
PAPSS1(1-223)-p-BRAF(381-766) fusion [cytosol]
(R-HSA-6802543)
0.527
2
UniProt:P30043 BLVRB
1
BLVRB [cytosol]
(R-HSA-189388)
0.527
2
UniProt:O75822 EIF3J
1
EIF3J [cytosol]
(R-HSA-72534)
0.527
2
UniProt:Q00341 HDLBP
1
HDLBP [plasma membrane]
(R-HSA-8858026)
0.527
2
UniProt:Q9Y2L1 DIS3
3
DIS3 [nucleolus]
(R-HSA-9935841)
DIS3 [nucleoplasm]
(R-HSA-6791517)
DIS3 [cytosol]
(R-HSA-429935)
0.527
2
UniProt:Q9UL46 PSME2
2
PSME2 [cytosol]
(R-HSA-68814)
PSME2 [nucleoplasm]
(R-HSA-174350)
0.527
2
UniProt:Q9Y490 TLN1
4
TLN1 [extracellular region]
(R-HSA-350693)
TLN1(434-2541) [cytosol]
(R-HSA-9855156)
TLN1(1-433) [cytosol]
(R-HSA-9855031)
TLN1 [cytosol]
(R-HSA-350713)
0.527
2
UniProt:P61586 RHOA
6
RHOA [plasma membrane]
(R-HSA-194510)
RHOA [cell junction]
(R-HSA-2134503)
RHOA [cytosol]
(R-HSA-194866)
RHOA [endoplasmic reticulum membrane]
(R-HSA-5672082)
RHOA [secretory granule membrane]
(R-HSA-6804980)
RHOA [ficolin-1-rich granule membrane]
(R-HSA-6804971)
0.527
2
UniProt:Q92917 GPKOW
1
GPKOW [nucleoplasm]
(R-HSA-8850839)
0.527
2
UniProt:O00625 PIR
1
PIR [nucleoplasm]
(R-HSA-8953390)
0.527
2
UniProt:Q16659 MAPK6 gene
6
p-3S,T MAPK6 [nucleoplasm]
(R-HSA-5692665)
MAPK6 [nucleoplasm]
(R-HSA-5692686)
p-S189 MAPK6 [nucleoplasm]
(R-HSA-5687015)
p-S189 MAPK6 [cytosol]
(R-HSA-5687019)
MAPK6 [cytosol]
(R-HSA-5686979)
ub-MAPK6 [cytosol]
(R-HSA-5687000)
0.527
2
UniProt:P39748 FEN1
1
FEN1 [nucleoplasm]
(R-HSA-54745)
0.527
2
UniProt:Q9NPD8 UBE2T
3
UBE2T [nucleoplasm]
(R-HSA-420942)
MonoUb-K91,K182-UBE2T [nucleoplasm]
(R-HSA-6785362)
Ub-C86-UBE2T [nucleoplasm]
(R-HSA-8864217)
0.527
2
UniProt:O43776 NARS1
1
NARS [cytosol]
(R-HSA-379625)
0.527
2
UniProt:Q01581 HMGCS1
1
HMGCS1 [cytosol]
(R-HSA-191329)
0.527
2
UniProt:Q13177 PAK2
11
p-S141,T402-PAK2 [cytosol]
(R-HSA-399824)
PAK2 [cytosol]
(R-HSA-211604)
p-5S-PAK2 [cytosol]
(R-HSA-211609)
PAK2(213-524) [cytosol]
(R-HSA-211653)
p-5S-PAK2(2-212) [cytosol]
(R-HSA-211588)
p-T402-PAK2(213-524) [cytosol]
(R-HSA-211654)
p-T402-PAK2(213-524) [nucleoplasm]
(R-HSA-211709)
K48polyUb-p-T402-PAK-2p43 [cytosol]
(R-HSA-3095873)
p-Y130,S141,T402-PAK2 [cytosol]
(R-HSA-5218705)
PAK2(1-524) [plasma membrane]
(R-HSA-164946)
p-S141,T402-PAK2 [plasma membrane]
(R-HSA-5096524)
0.527
2
UniProt:P62495 ETF1
3
ETF1 [cytosol]
(R-HSA-54433)
4OHK63-ETF1 [cytosol]
(R-HSA-9629948)
Me-Q185-ETF1 [cytosol]
(R-HSA-6800157)
0.527
2
UniProt:P41743 PRKCI
3
PRKCI [nucleoplasm]
(R-HSA-9021345)
PRKCI [cytosol]
(R-HSA-58206)
PRKCI [plasma membrane]
(R-HSA-420005)
0.527
2
UniProt:O60361 NME2P1
1
NME2P1 [cytosol]
(R-HSA-6806876)
0.527
2
UniProt:Q8WZA0 LZIC
0.527
2
UniProt:P27348 YWHAQ
1
YWHAQ [cytosol]
(R-HSA-1445116)
0.527
2
UniProt:Q9BY44 EIF2A
0.527
2
UniProt:Q8WVY7 UBCP1
0.527
2
UniProt:Q99986 VRK1
2
VRK1 [cytosol]
(R-HSA-2995381)
VRK1 [nucleoplasm]
(R-HSA-2528998)
0.527
2
UniProt:O60493 SNX3
3
SNX3 [cytosol]
(R-HSA-3247743)
PolyUb-SNX3 [endosome membrane]
(R-HSA-6782993)
SNX3 [endosome membrane]
(R-HSA-6782991)
0.527
2
UniProt:Q15459 SF3A1
1
SF3A1 [nucleoplasm]
(R-HSA-71962)
0.527
2
UniProt:P06899 H2BC11
9
HIST1H2BJ [nucleoplasm]
(R-HSA-181900)
Ub-121-HIST1H2BJ [nucleoplasm]
(R-HSA-3364017)
AcK13-HIST1H2BJ [nucleoplasm]
(R-HSA-4568662)
AcK16-HIST1H2BJ [nucleoplasm]
(R-HSA-4568704)
AcK6-HIST1H2BJ [nucleoplasm]
(R-HSA-4568668)
AcK21-HIST1H2BJ [nucleoplasm]
(R-HSA-4568671)
HIST1H2BJ [extracellular region]
(R-HSA-977565)
AcK-HIST1H2BJ [nucleoplasm]
(R-HSA-4549258)
Ub-HIST1H2BJ [nucleoplasm]
(R-HSA-6782566)
0.527
2
UniProt:Q96FW1 OTUB1
2
OTUB1 [cytosol]
(R-HSA-933411)
OTUB1 [nucleoplasm]
(R-HSA-6783242)
0.527
2
UniProt:Q96A49 SYAP1
0.527
2
UniProt:Q9BY32 ITPA
1
ITPA [cytosol]
(R-HSA-2509850)
0.527
2
UniProt:Q07960 ARHGAP1
1
ARHGAP1 [cytosol]
(R-HSA-195193)
0.527
2
UniProt:P05091 ALDH2
1
ALDH2 [mitochondrial matrix]
(R-HSA-71718)
0.527
2
UniProt:P36915 GNL1
0.527
2
UniProt:O95202 LETM1
2
LETM1 [endoplasmic reticulum membrane]
(R-HSA-9714759)
LETM1 [mitochondrial inner membrane]
(R-HSA-8949702)
0.527
2
UniProt:O75436 VPS26A
1
VPS26A [cytosol]
(R-HSA-3247739)
0.527
2
UniProt:Q58FG1 HS904
0.527
2
UniProt:Q9Y3A5 SBDS
0.527
2
UniProt:Q9BXJ9 NAA15
0.527
2
UniProt:Q9NVS9 PNPO
1
PNPO [cytosol]
(R-HSA-965023)
0.527
2
UniProt:O43583 DENR
0.527
2
UniProt:Q15126 PMVK
1
PMVK [cytosol]
(R-HSA-191348)
0.527
2
UniProt:Q9NTZ6 RBM12
0.527
2
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