Reactome | factor X -> factor Xa + factor X activation peptide (TF:F7a catalyst)

factor X -> factor Xa + factor X activation peptide (TF:F7a catalyst)

Stable Identifier

R-HSA-140736

Type

Reaction [transition]

Species

Homo sapiens

Compartment

extracellular region, plasma membrane

Synonyms

activation of factor X by TF:F7a

ReviewStatus

5/5

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factor X -> factor Xa + factor X activation peptide (TF:F7a catalyst)

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Factor VIIa, bound to tissue factor at the endothelial cell surface (the "extrinsic tenase complex"), catalyzes the formation of activated factor X with high efficiency. The amino terminal part of the heavy chain of factor X, the factor X activation peptide, is released. (This peptide has no known function.)

Literature References

PubMed ID	Title	Journal	Year
8578528	The tissue factor pathway: how it has become a "prima ballerina" Rao, LV, Rapaport, SI	Thromb Haemost	1995
2248955	Proteolytic activation of human factors IX and X by recombinant human factor VIIa: effects of calcium, phospholipids, and tissue factor Kisiel, W, Pedersen, AH, Komiyama, Y	Biochemistry	1990
6980899	Binding of human factor VII and VIIa to monocytes Broze, GJ Jr	J Clin Invest	1982