Reactome | sequestered tissue factor [plasma membrane]

sequestered tissue factor [plasma membrane]

Stable Identifier

R-HSA-140762

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

Locations in the PathwayBrowser

Expand all

Signal Transduction (Homo sapiens)

- Signaling by Receptor Tyrosine Kinases (Homo sapiens)
  - Signaling by NTRKs (Homo sapiens)
    - Signaling by NTRK1 (TRKA) (Homo sapiens)
      - Nuclear Events (kinase and transcription factor activation) (Homo sapiens)
        
        NGF-stimulated transcription (Homo sapiens)
        
        TF gene expression (Homo sapiens)
        
        sequestered tissue factor [plasma membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:P13726 TF

Gene Names

TF, F3

Chain

signal peptide:1-32, chain:33-295

Reference Genes

BioGPS Gene:2152 TF

COSMIC (genes):TF TF

CTD Gene:2152 TF

dbSNP Gene:2152 TF

ENSEMBL:ENSG00000117525 TF

ENSEMBL_homo_sapiens_GENE:ENSG00000117525.14 TF

HGNC:3541 TF

KEGG Gene (Homo sapiens):2152 TF

Monarch:2152 TF

NCBI Gene:2152 TF

OMIM:134390 TF

UCSC:P13726 TF

Reference Transcript

Other Identifiers

11721290_a_at

11721291_a_at

11755733_a_at

16689869

204363_PM_at

204363_at

2152

2423910

2423911

2423912

2423913

2423914

2423915

2423916

2423918

2423920

2423922

2423923

2423924

2423928

2423933

2423934

2423935

36543_at

7917875

A_23_P126782

A_33_P3226832

GE475336

GE57466

GO:0001938

GO:0002020

GO:0002541

GO:0002543

GO:0003824

GO:0004252

GO:0004896

GO:0005515

GO:0005543

GO:0005576

GO:0005615

GO:0005886

GO:0006919

GO:0006954

GO:0007596

GO:0007599

GO:0008289

GO:0009897

GO:0009986

GO:0010628

GO:0010641

GO:0016020

GO:0016485

GO:0016787

GO:0019221

GO:0023052

GO:0030312

GO:0030335

GO:0031012

GO:0032008

GO:0032757

GO:0042060

GO:0045766

GO:0048856

GO:0048870

GO:0050927

GO:0051604

GO:0060089

GO:0062023

GO:0140096

GO:1905286

HMNXSV003048205

ILMN_1797009

M27436_s_at

PH_hs_0003939

TC01002886.hg

g10518499_3p_at

Participates

as an input of

sequestered tissue factor -> tissue factor (Homo sapiens)

as an output of

TF gene expression (Homo sapiens)

Other forms of this molecule

PalmC, 2HC-F3 [plasma membrane]

Inferred To

F3 [plasma membrane] (Bos taurus)

F3 [plasma membrane] (Canis familiaris)

F3 [plasma membrane] (Mus musculus)

F3 [plasma membrane] (Rattus norvegicus)

F3 [plasma membrane] (Sus scrofa)

f3a [plasma membrane] (Danio rerio)

sequestered tissue factor [plasma membrane] (Gallus gallus)

Cross References

RefSeq

NP_001171567.1, NP_001984.1

Guide to Pharmacology - Targets

3192

OpenTargets

ENSG00000091513

ZINC - Substances

TF_HUMAN

ZINC - Biogenic

TF_HUMAN

ZINC target

P13726

PRO

P13726

PDB

2EC9, 1WTG, 6Z9W, 2ZP0, 2FLR, 2ZWL, 3TH2, 4M7L, 4ZMA, 2CEF, 1Z6J, 2F9B, 1AHW, 1FAK, 1WSS, 5W06, 2FIR, 2AER, 6R2W, 2B8O, 1W0Y, 1UJ3, 2AEI, 4YLQ, 2PUQ, 4Z6A, 3ELA, 1WV7, 2CEZ, 1J9C, 1WUN, 3TH3, 2HFT, 4IBL, 2B7D, 3TH4, 1WQV, 1TFH, 2CFJ, 1DAN, 2C4F, 8CN9, 1BOY, 2CEH, 1W2K, 2FLB, 2ZZU, 1JPS, 1O5D, 2A2Q

ZINC - Investigational

TF_HUMAN

HPA

ENSG00000117525-F3

GeneCards

P13726

Ensembl

ENST00000370207, ENST00000334047, ENSP00000359226, ENSP00000334145, ENSG00000117525

Pharos - Targets

P13726

ZINC - Predictions - Purchasable

TF_HUMAN

Interactors (3)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P08709 F7	11	factor VII propeptide [Golgi lumen] (R-HSA-159847) factor VII [Golgi lumen] (R-HSA-159808) pro-factor VII [Golgi lumen] (R-HSA-159767) 10xCbxE-F7(21-466) [endoplasmic reticulum lumen] (R-HSA-159722) F7(21-466) [endoplasmic reticulum lumen] (R-HSA-159848) 10xCbxE-F7(61-466) [plasma membrane] (R-HSA-140774) 10xCbxE-F7(61-466) [extracellular region] (R-HSA-140771) 10xCbxE-F7(61-212) [extracellular region] (R-HSA-140749) factor VIIa heavy chain [extracellular region] (R-HSA-140750) 10xCbxE-F7(61-212) [plasma membrane] (R-HSA-140715) factor VIIa heavy chain [plasma membrane] (R-HSA-140724)	0.881	7
UniProt:Q92544 TM9S4			0.564	2
UniProt:Q9UM19 HPCL4			0.556	3