Reactome | factor X -> factor Xa + factor X activation peptide (TF:F7 catalyst)

factor X -> factor Xa + factor X activation peptide (TF:F7 catalyst)

Stable Identifier

R-HSA-140777

Type

Reaction [transition]

Species

Homo sapiens

Compartment

extracellular region, plasma membrane

Synonyms

activation of factor X by TF:F7

ReviewStatus

5/5

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factor X -> factor Xa + factor X activation peptide (TF:F7 catalyst)

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Factor VII, bound to tissue factor at the endothelial cell surface, catalyzes the activation of factor X from plasma with moderate efficiency. The amino terminal part of the heavy chain of factor X, the factor X activation peptide, is released. (This peptide has no known function.)

Literature References

PubMed ID	Title	Journal	Year
3275472	Tissue factor and hemostasis Nemerson, Y	Blood	1988
3527261	Factor VII binding to tissue factor in reconstituted phospholipid vesicles: induction of cooperativity by phosphatidylserine Gentry, R, Bach, R, Nemerson, Y	Biochemistry	1986
6980899	Binding of human factor VII and VIIa to monocytes Broze, GJ Jr	J Clin Invest	1982