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factor X activation peptide [extracellular region]
Stable Identifier
R-HSA-140785
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
extracellular region
Synonyms
F10(183-234)
Icon
Locations in the PathwayBrowser for interactor UniProt:Q9UK55 SERPINA10
Expand all
Disease (Homo sapiens)
Diseases of hemostasis (Homo sapiens)
Defects of contact activation system (CAS) and kallikrein/kinin system (KKS) (Homo sapiens)
Defective factor IX causes thrombophilia (Homo sapiens)
Hyperactivation of factor X by FVIIIa:FIXa R384L (Homo sapiens)
factor X activation peptide [extracellular region] (Homo sapiens)
Hemostasis (Homo sapiens)
Formation of Fibrin Clot (Clotting Cascade) (Homo sapiens)
Extrinsic Pathway of Fibrin Clot Formation (Homo sapiens)
factor X -> factor Xa + factor X activation peptide (TF:F7 catalyst) (Homo sapiens)
factor X activation peptide [extracellular region] (Homo sapiens)
factor X -> factor Xa + factor X activation peptide (TF:F7a catalyst) (Homo sapiens)
factor X activation peptide [extracellular region] (Homo sapiens)
Intrinsic Pathway of Fibrin Clot Formation (Homo sapiens)
factor X -> factor Xa + factor X activation peptide (VIIIa:IXa catalyst) (Homo sapiens)
factor X activation peptide [extracellular region] (Homo sapiens)
Literature References
PubMed ID
Title
Journal
Year
921929
Activation of human factor X (Stuart factor) by a protease from Russell's viper venom
DiScipio, RG
,
Hermodson, MA
,
Davie, EW
Biochemistry
1977
External Reference Information
External Reference
UniProt:P00742 F10
Gene Names
F10
Chain
signal peptide:1-31, propeptide:32-40, chain:41-488, chain:41-179, chain:183-488, propeptide:183-234, chain:235-488
Reference Genes
BioGPS Gene:2159 F10
COSMIC (genes):F10 F10
CTD Gene:2159 F10
dbSNP Gene:2159 F10
ENSEMBL:ENSG00000126218 F10
ENSEMBL_homo_sapiens_GENE:ENSG00000126218.12 F10
HGNC:3528 F10
KEGG Gene (Homo sapiens):2159 F10
Monarch:2159 F10
NCBI Gene:2159 F10
OMIM:613872 F10
Reference Transcript
RefSeq:NM_001312675.1 F10
RefSeq:NM_000504.3 F10
RefSeq:NM_001312674.1 F10
Other Identifiers
11723802_at
16776798
205620_PM_at
205620_at
2159
3502440
3502441
3502444
3502447
3502450
3502452
3502453
3502455
3502456
3502457
3502458
3502459
39979_at
7970241
A_23_P205177
GE60493
GO:0003824
GO:0004252
GO:0005509
GO:0005515
GO:0005543
GO:0005576
GO:0005615
GO:0005783
GO:0005788
GO:0005794
GO:0005796
GO:0005886
GO:0006508
GO:0007596
GO:0007599
GO:0008233
GO:0008236
GO:0008289
GO:0009897
GO:0016787
GO:0023052
GO:0030335
GO:0032008
GO:0042060
GO:0043226
GO:0048870
GO:0140096
HMNXSV003031147
ILMN_1670708
L29433_at
PH_hs_0024025
TC13000417.hg
g9961350_3p_at
g9961350_3p_x_at
Participates
as an output of
Hyperactivation of factor X by FVIIIa:FIXa R384L (Homo sapiens)
factor X -> factor Xa + factor X activation peptide (VIIIa:IXa catalyst) (Homo sapiens)
factor X -> factor Xa + factor X activation peptide (TF:F7 catalyst) (Homo sapiens)
factor X -> factor Xa + factor X activation peptide (TF:F7a catalyst) (Homo sapiens)
Other forms of this molecule
11xCbxE-3D-F10(41-179) [Golgi lumen]
factor X light chain propeptide [Golgi lumen]
11xCbxE-3D-F10(32-179) [Golgi lumen]
factor X heavy chain [Golgi lumen]
11xCbxE-3D-F10(32-179) [endoplasmic reticulum lumen]
factor X heavy chain [endoplasmic reticulum lumen]
3D-F10(32-179) [endoplasmic reticulum lumen]
factor X heavy chain [extracellular region]
11xCbxE-3D-F10(41-179) [extracellular region]
factor Xa heavy chain [extracellular region]
11xCbxE-3D-F10(41-179) [plasma membrane]
factor Xa heavy chain [plasma membrane]
Inferred To
f10 [extracellular region]
(Xenopus tropicalis)
F7 [extracellular region]
(Bos taurus)
F10 [extracellular region]
(Canis familiaris)
F10 [extracellular region]
(Gallus gallus)
F10 [extracellular region]
(Mus musculus)
F10 [extracellular region]
(Rattus norvegicus)
F10 [extracellular region]
(Sus scrofa)
proza [extracellular region]
(Danio rerio)
Cross References
RefSeq
NP_000495.1
,
NP_001299604.1
,
NP_001299603.1
ZINC - World Drugs
FA10_HUMAN
Guide to Pharmacology - Targets
2359
OpenTargets
ENSG00000126218
ZINC - FDA approved
FA10_HUMAN
ZINC - Substances
FA10_HUMAN
ZINC target
P00742
ZINC - Biogenic
FA10_HUMAN
PRO
P00742
PDB
3ENS
,
2VWO
,
3KQC
,
6Q9I
,
5VOF
,
6YYW
,
2UWL
,
1IQI
,
4ZH8
,
2P3F
,
2WYJ
,
2J2U
,
2J4I
,
3FFG
,
2Y7X
,
2UWP
,
1IQK
,
5JQY
,
1LPK
,
2XBW
,
1G2M
,
5JZ8
,
1NFU
,
1IQE
,
1XKB
,
2EI7
,
1FAX
,
2J94
,
3KQE
,
2Y5H
,
1V3X
,
2PR3
,
2XBY
,
2BMG
,
4Y71
,
4BTT
,
6Z6R
,
3SW2
,
1IQG
,
2XC5
,
1FJS
,
7YB9
,
5JZU
,
1C5M
,
2PHB
,
1MQ6
,
2P94
,
2VVV
,
7TPP
,
2Y81
,
7BMI
,
2J34
,
1P0S
,
4Y7B
,
4A7I
,
3TK6
,
1IQM
,
2EI8
,
4Y76
,
2BQW
,
5K0H
,
5JTC
,
2VVC
,
3Q3K
,
2VWM
,
1IQN
,
2BOH
,
6Z6Q
,
2W3K
,
6YYY
,
1NFX
,
2P3T
,
1FXY
,
7YBB
,
2VH6
,
2BQ6
,
1F0R
,
2UWO
,
1IQH
,
6YYX
,
4BTI
,
3KQD
,
3CS7
,
4Y6D
,
2VWN
,
2D1J
,
6Q9F
,
1XKA
,
1IQJ
,
2WYG
,
5VOE
,
2Y7Z
,
3KQB
,
1F0S
,
1LPG
,
2VVU
,
3IIT
,
2Q1J
,
2XBV
,
2G00
,
2FZZ
,
1G2L
,
2Y82
,
2J38
,
1Z6E
,
3CEN
,
1NFW
,
3M36
,
2EI6
,
2H9E
,
2GD4
,
2Y5G
,
2XC0
,
2XBX
,
2W26
,
1HCG
,
1LPZ
,
3K9X
,
2J95
,
4BTU
,
4ZHA
,
1IQF
,
1KSN
,
2P16
,
1MQ5
,
2CJI
,
2BOK
,
7YB8
,
8EOK
,
2BQ7
,
2XC4
,
1LQD
,
3KL6
,
7BMJ
,
3M37
,
3HPT
,
1EZQ
,
2P93
,
2Y80
,
4Y7A
,
3TK5
,
7TPQ
,
1IQL
,
2VH0
,
6RK9
,
4Y79
,
7E6J
,
1IOE
,
2P95
,
3LIW
,
7AHU
,
1WU1
,
2JKH
,
2RA0
,
2W3I
,
1NFY
,
7YBC
,
2VWL
,
2P3U
,
2Y5F
ZINC - Investigational
FA10_HUMAN
HPA
ENSG00000126218-F10
GeneCards
P00742
Ensembl
ENST00000375559
,
ENSP00000364709
,
ENSG00000126218
Pharos - Targets
P00742
Orphanet
16008
ZINC - Predictions - Purchasable
FA10_HUMAN
HMDB Protein
HMDBP02011
Interactors (3)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q9UK55 SERPINA10
2
p-SERPINA10 [endoplasmic reticulum lumen]
(R-HSA-8956990)
SERPINA10 [endoplasmic reticulum lumen]
(R-HSA-8956739)
0.558
2
UniProt:P0DPK4 NOTCH2NLC
1
NOTCH2NLC [extracellular region]
(R-HSA-9908932)
0.556
3
UniProt:Q9UHD9 UBQLN2
1
UBQLN2 [cytosol]
(R-HSA-8866007)
0.556
3
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