Reactome | FGA(20-35) [extracellular region]

FGA(20-35) [extracellular region]

Stable Identifier

R-HSA-140867

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

extracellular region

Synonyms

fibrinopeptide A

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Locations in the PathwayBrowser for interactor UniProt:P02675 FGB

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External Reference Information

External Reference

UniProt:P02671 FGA

Gene Names

FGA

Chain

signal peptide:1-19, peptide:20-35, chain:36-866

Reference Genes

BioGPS Gene:2243 FGA

COSMIC (genes):FGA FGA

CTD Gene:2243 FGA

dbSNP Gene:2243 FGA

ENSEMBL:ENSG00000171560 FGA

HGNC:3661 FGA

KEGG:hsa:2243 FGA

Monarch:2243 FGA

NCBI Gene:2243 FGA

OMIM:134820 FGA

UCSC:P02671 FGA

Reference Transcript

Participates

as an output of

fibrinogen -> fibrin monomer + 2 fibrinopeptide A + 2 fibrinopeptide B (Homo sapiens)

as a member of

FGA, FGB, FGG [extracellular region] (Homo sapiens)

Other forms of this molecule

FGA [extracellular region]

FGA [endoplasmic reticulum lumen]

p-FGA [endoplasmic reticulum lumen]

FGA(20-866) [platelet alpha granule lumen]

FGA(20-866) [extracellular region]

FGA [plasma membrane]

Variant fibrinogen alpha chain [extracellular region]

Inferred To

Fga [extracellular region] (Mus musculus)

Fga [extracellular region] (Rattus norvegicus)

FGA [extracellular region] (Bos taurus)

FGA [extracellular region] (Sus scrofa)

FGA(20-35) [extracellular region] (Canis familiaris)

FGA(20-35) [extracellular region] (Gallus gallus)

Cross References

RefSeq

NP_000499.1, NP_068657.1

OpenTargets

ENSG00000171560

ENSEMBL

ENSP00000498441, ENSG00000171560, ENSP00000385981, ENST00000403106, ENST00000651975

HPA

ENSG00000171560-FGA

GeneCards

FGA

PRO

P02671

Pharos - Targets

P02671

Orphanet

FGA

GlyGen

P02671

HMDB Protein

HMDBP13512

PDB

3HUS, 3H32, 1N86, 2Q9I, 1RE3, 5CFA, 2HPC, 1N8E, 1FZD, 1FZC, 2HLO, 1FZA, 1FZB, 3AT0, 1BBR, 3BVH, 1LT9, 1FZE, 1FZF, 1FZG, 1DM4, 1LTJ, 4F27, 1YCP, 3GHG, 3E1I, 2XNX, 2Z4E, 1FPH, 2XNY, 2OYH, 1RF1, 2HOD, 2A45, 2H43, 2OYI, 1RF0, 1RE4, 2FFD

Interactors (7)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P02675 FGB	5	FGB [extracellular region] (R-HSA-140584) FGB(31-44) [extracellular region] (R-HSA-140876) FGB(31-491) [platelet alpha granule lumen] (R-HSA-140921) FGB(31-491) [extracellular region] (R-HSA-140846) FGB [plasma membrane] (R-HSA-140917)	0.852	11
UniProt:P02679 FGG	5	FGG [extracellular region] (R-HSA-140585) FGG [endoplasmic reticulum lumen] (R-HSA-8956692) p-FGG [endoplasmic reticulum lumen] (R-HSA-8956993) FGG [platelet alpha granule lumen] (R-HSA-140922) FGG [plasma membrane] (R-HSA-140918)	0.852	11
UniProt:Q8IXL6 FAM20C	1	FAM20C [endoplasmic reticulum lumen] (R-HSA-8952276)	0.623	2
UniProt:P27348 YWHAQ	1	YWHAQ [cytosol] (R-HSA-1445116)	0.564	2
UniProt:P0DTC8 8	2	8 [extracellular region] (R-COV-9755410) 8 [endoplasmic reticulum lumen] (R-COV-9727283)	0.547	2
UniProt:Q99XV0 Q99XV0			0.524	2
UniProt:P02647 APOA1	11	APOA1 [endoplasmic reticulum lumen] (R-HSA-8956724) p-APOA1 [endoplasmic reticulum lumen] (R-HSA-8957081) APOA1(25-266) [extracellular region] (R-HSA-174720) APOA1(25-266) [endocytic vesicle lumen] (R-HSA-2239460) Variant apolipoprotein AI [extracellular region] (R-HSA-976865) APOA1(25-266) [plasma membrane] (R-HSA-216742) APOA1(19-266) [extracellular region] (R-HSA-264771) APOA1(25-267) [endoplasmic reticulum lumen] (R-HSA-174640) APOA1(25-267) [early endosome] (R-HSA-2429641) APOA1(25-267) [cytosol] (R-HSA-2395781) APOA1(25-266) [secretory granule lumen] (R-HSA-350761)	0.483	2

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