Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
TRAF2:TRADD:RIPK1 [cytosol]
Stable Identifier
R-HSA-140935
Type
Complex
Species
Homo sapiens
Compartment
cytosol
GO Cellular Component
death-inducing signaling complex
(0031264)
Locations in the PathwayBrowser
Expand all
Programmed Cell Death (Homo sapiens)
Apoptosis (Homo sapiens)
Caspase activation via extrinsic apoptotic signalling pathway (Homo sapiens)
Caspase activation via Death Receptors in the presence of ligand (Homo sapiens)
Caspase-8 processing in the DISC (Homo sapiens)
DISC [plasma membrane] (Homo sapiens)
TRADD:TRAF2:RIPK1:FADD [cytosol] (Homo sapiens)
TRAF2:TRADD:RIPK1 [cytosol] (Homo sapiens)
DISC:procaspase-8-dimer [plasma membrane] (Homo sapiens)
TRAF2:TRADD:RIP1:FADD:2xCASP8(1-479) [cytosol] (Homo sapiens)
TRADD:TRAF2:RIPK1:FADD [cytosol] (Homo sapiens)
TRAF2:TRADD:RIPK1 [cytosol] (Homo sapiens)
Dimerization of procaspase-8 (Homo sapiens)
TNF-mediated dimerization of procaspase-8 (Homo sapiens)
TRADD:TRAF2:RIP1:FADD:CASP8(1-479) [cytosol] (Homo sapiens)
TRADD:TRAF2:RIPK1:FADD [cytosol] (Homo sapiens)
TRAF2:TRADD:RIPK1 [cytosol] (Homo sapiens)
TRAF2:TRADD:RIP1:FADD:2xCASP8(1-479) [cytosol] (Homo sapiens)
TRADD:TRAF2:RIPK1:FADD [cytosol] (Homo sapiens)
TRAF2:TRADD:RIPK1 [cytosol] (Homo sapiens)
Regulation by c-FLIP (Homo sapiens)
Caspase-8 and FLIP(L) processing at DISC (Homo sapiens)
DISC:p43/p41CASP8:p43 FLIP(L) [plasma membrane] (Homo sapiens)
DISC [plasma membrane] (Homo sapiens)
TRADD:TRAF2:RIPK1:FADD [cytosol] (Homo sapiens)
TRAF2:TRADD:RIPK1 [cytosol] (Homo sapiens)
DISC:procaspase-8:FLIP(L) [plasma membrane] (Homo sapiens)
DISC:procaspase-8 [plasma membrane] (Homo sapiens)
DISC [plasma membrane] (Homo sapiens)
TRADD:TRAF2:RIPK1:FADD [cytosol] (Homo sapiens)
TRAF2:TRADD:RIPK1 [cytosol] (Homo sapiens)
FLIP(L) and procaspase-8 form heterodimer in TNF signaling (Homo sapiens)
TRADD:TRAF2:RIP1:FADD:procaspase-8:FLIP(L) [cytosol] (Homo sapiens)
TRADD:TRAF2:RIPK1:FADD [cytosol] (Homo sapiens)
TRAF2:TRADD:RIPK1 [cytosol] (Homo sapiens)
TRADD:TRAF2:RIPK1:FADD [cytosol] (Homo sapiens)
TRAF2:TRADD:RIPK1 [cytosol] (Homo sapiens)
Regulated Necrosis (Homo sapiens)
RIPK1-mediated regulated necrosis (Homo sapiens)
RIPK3 binds RIPK1 (Homo sapiens)
DISC:procaspase-8:FLIP(L) [plasma membrane] (Homo sapiens)
DISC:procaspase-8 [plasma membrane] (Homo sapiens)
DISC [plasma membrane] (Homo sapiens)
TRADD:TRAF2:RIPK1:FADD [cytosol] (Homo sapiens)
TRAF2:TRADD:RIPK1 [cytosol] (Homo sapiens)
DISC:procaspase-8:FLIP(S) [plasma membrane] (Homo sapiens)
DISC:procaspase-8 [plasma membrane] (Homo sapiens)
DISC [plasma membrane] (Homo sapiens)
TRADD:TRAF2:RIPK1:FADD [cytosol] (Homo sapiens)
TRAF2:TRADD:RIPK1 [cytosol] (Homo sapiens)
Regulation of necroptotic cell death (Homo sapiens)
CASP8 activity is inhibited (Homo sapiens)
FLIP(L) and procaspase-8 form heterodimer (Homo sapiens)
DISC:procaspase-8 [plasma membrane] (Homo sapiens)
DISC [plasma membrane] (Homo sapiens)
TRADD:TRAF2:RIPK1:FADD [cytosol] (Homo sapiens)
TRAF2:TRADD:RIPK1 [cytosol] (Homo sapiens)
DISC:procaspase-8:FLIP(L) [plasma membrane] (Homo sapiens)
DISC:procaspase-8 [plasma membrane] (Homo sapiens)
DISC [plasma membrane] (Homo sapiens)
TRADD:TRAF2:RIPK1:FADD [cytosol] (Homo sapiens)
TRAF2:TRADD:RIPK1 [cytosol] (Homo sapiens)
FLIP(S) and procaspase-8 form heterodimer (Homo sapiens)
DISC:procaspase-8 [plasma membrane] (Homo sapiens)
DISC [plasma membrane] (Homo sapiens)
TRADD:TRAF2:RIPK1:FADD [cytosol] (Homo sapiens)
TRAF2:TRADD:RIPK1 [cytosol] (Homo sapiens)
DISC:procaspase-8:FLIP(S) [plasma membrane] (Homo sapiens)
DISC:procaspase-8 [plasma membrane] (Homo sapiens)
DISC [plasma membrane] (Homo sapiens)
TRADD:TRAF2:RIPK1:FADD [cytosol] (Homo sapiens)
TRAF2:TRADD:RIPK1 [cytosol] (Homo sapiens)
RIPK1 is cleaved by CASP8 (Homo sapiens)
TRADD:TRAF2:RIPK1:FADD [cytosol] (Homo sapiens)
TRAF2:TRADD:RIPK1 [cytosol] (Homo sapiens)
Signal Transduction (Homo sapiens)
Death Receptor Signaling (Homo sapiens)
TNF signaling (Homo sapiens)
Regulation of TNFR1 signaling (Homo sapiens)
Caspase-8 and FLIP(L) processing at TNFR signaling complex (Homo sapiens)
TRADD:TRAF2:RIP1:FADD:procaspase-8:FLIP(L) [cytosol] (Homo sapiens)
TRADD:TRAF2:RIPK1:FADD [cytosol] (Homo sapiens)
TRAF2:TRADD:RIPK1 [cytosol] (Homo sapiens)
TRADD:TRAF2:RIPK1:FADD:p43/p41CASP8:p43 FLIP(L) [plasma membrane] (Homo sapiens)
TRADD:TRAF2:RIPK1:FADD [cytosol] (Homo sapiens)
TRAF2:TRADD:RIPK1 [cytosol] (Homo sapiens)
FLIP(L) and procaspase-8 form heterodimer in TNF signaling (Homo sapiens)
TRADD:TRAF2:RIP1:FADD:procaspase-8:FLIP(L) [cytosol] (Homo sapiens)
TRADD:TRAF2:RIPK1:FADD [cytosol] (Homo sapiens)
TRAF2:TRADD:RIPK1 [cytosol] (Homo sapiens)
TRADD:TRAF2:RIPK1:FADD [cytosol] (Homo sapiens)
TRAF2:TRADD:RIPK1 [cytosol] (Homo sapiens)
MAPKAPK2 phosphorylates RIPK1 at S320 (Homo sapiens)
TRAF2:TRADD:RIPK1 [cytosol] (Homo sapiens)
RIPK1 is cleaved by CASP8 (Homo sapiens)
TRADD:TRAF2:RIPK1:FADD [cytosol] (Homo sapiens)
TRAF2:TRADD:RIPK1 [cytosol] (Homo sapiens)
RIPK1 is cleaved by CASP8:FLIP(L) (Homo sapiens)
TRADD:TRAF2:RIPK1:FADD:p43/p41CASP8:p43 FLIP(L) [plasma membrane] (Homo sapiens)
TRADD:TRAF2:RIPK1:FADD [cytosol] (Homo sapiens)
TRAF2:TRADD:RIPK1 [cytosol] (Homo sapiens)
ULK1 phosphorylates RIPK1 at S357 (Homo sapiens)
TRAF2:TRADD:RIPK1 [cytosol] (Homo sapiens)
TNFR1-induced proapoptotic signaling (Homo sapiens)
TRADD:TRAF2:RIP1 binds FADD (Homo sapiens)
TRADD:TRAF2:RIPK1:FADD [cytosol] (Homo sapiens)
TRAF2:TRADD:RIPK1 [cytosol] (Homo sapiens)
TRAF2:TRADD:RIPK1 [cytosol] (Homo sapiens)
TRADD:TRAF2:RIP1 dissociates from TNF-α:TNFR1 (Homo sapiens)
TRAF2:TRADD:RIPK1 [cytosol] (Homo sapiens)
TRADD:TRAF2:RIP1:FADD binds pro-caspase 8 (Homo sapiens)
TRADD:TRAF2:RIP1:FADD:CASP8(1-479) [cytosol] (Homo sapiens)
TRADD:TRAF2:RIPK1:FADD [cytosol] (Homo sapiens)
TRAF2:TRADD:RIPK1 [cytosol] (Homo sapiens)
TRADD:TRAF2:RIPK1:FADD [cytosol] (Homo sapiens)
TRAF2:TRADD:RIPK1 [cytosol] (Homo sapiens)
Participants
components
RIPK1 [cytosol]
(Homo sapiens)
x 3
TRADD [cytosol]
(Homo sapiens)
x 3
TRAF2 [cytosol]
(Homo sapiens)
Participates
as an input of
ULK1 phosphorylates RIPK1 at S357 (Homo sapiens)
MAPKAPK2 phosphorylates RIPK1 at S320 (Homo sapiens)
TRADD:TRAF2:RIP1 binds FADD (Homo sapiens)
as an output of
TRADD:TRAF2:RIP1 dissociates from TNF-α:TNFR1 (Homo sapiens)
as a component of
TRADD:TRAF2:RIPK1:FADD [cytosol] (Homo sapiens)
Inferred To
TRAF2:TRADD:RIPK1 [cytosol]
(Bos taurus)
TRAF2:TRADD:RIPK1 [cytosol]
(Canis familiaris)
TRAF2:TRADD:RIPK1 [cytosol]
(Gallus gallus)
TRAF2:TRADD:RIPK1 [cytosol]
(Mus musculus)
TRAF2:TRADD:RIPK1 [cytosol]
(Rattus norvegicus)
TRAF2:TRADD:RIPK1 [cytosol]
(Sus scrofa)
TRAF2:TRADD:RIPK1 [cytosol]
(Xenopus tropicalis)
© 2025
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text