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TRADD:TRAF2:RIPK1:FADD [cytosol]
Stable Identifier
R-HSA-140977
Type
Complex
Species
Homo sapiens
Compartment
cytosol
GO Cellular Component
death-inducing signaling complex
(0031264)
Locations in the PathwayBrowser
Expand all
Programmed Cell Death (Homo sapiens)
Apoptosis (Homo sapiens)
Caspase activation via extrinsic apoptotic signalling pathway (Homo sapiens)
Caspase activation via Death Receptors in the presence of ligand (Homo sapiens)
Caspase-8 processing in the DISC (Homo sapiens)
DISC [plasma membrane] (Homo sapiens)
TRADD:TRAF2:RIPK1:FADD [cytosol] (Homo sapiens)
DISC:procaspase-8-dimer [plasma membrane] (Homo sapiens)
TRAF2:TRADD:RIP1:FADD:2xCASP8(1-479) [cytosol] (Homo sapiens)
TRADD:TRAF2:RIPK1:FADD [cytosol] (Homo sapiens)
Dimerization of procaspase-8 (Homo sapiens)
TNF-mediated dimerization of procaspase-8 (Homo sapiens)
TRADD:TRAF2:RIP1:FADD:CASP8(1-479) [cytosol] (Homo sapiens)
TRADD:TRAF2:RIPK1:FADD [cytosol] (Homo sapiens)
TRAF2:TRADD:RIP1:FADD:2xCASP8(1-479) [cytosol] (Homo sapiens)
TRADD:TRAF2:RIPK1:FADD [cytosol] (Homo sapiens)
Regulation by c-FLIP (Homo sapiens)
Caspase-8 and FLIP(L) processing at DISC (Homo sapiens)
DISC:p43/p41CASP8:p43 FLIP(L) [plasma membrane] (Homo sapiens)
DISC [plasma membrane] (Homo sapiens)
TRADD:TRAF2:RIPK1:FADD [cytosol] (Homo sapiens)
DISC:procaspase-8:FLIP(L) [plasma membrane] (Homo sapiens)
DISC:procaspase-8 [plasma membrane] (Homo sapiens)
DISC [plasma membrane] (Homo sapiens)
TRADD:TRAF2:RIPK1:FADD [cytosol] (Homo sapiens)
FLIP(L) and procaspase-8 form heterodimer in TNF signaling (Homo sapiens)
TRADD:TRAF2:RIP1:FADD:procaspase-8:FLIP(L) [cytosol] (Homo sapiens)
TRADD:TRAF2:RIPK1:FADD [cytosol] (Homo sapiens)
TRADD:TRAF2:RIPK1:FADD [cytosol] (Homo sapiens)
Regulated Necrosis (Homo sapiens)
RIPK1-mediated regulated necrosis (Homo sapiens)
RIPK3 binds RIPK1 (Homo sapiens)
DISC:procaspase-8:FLIP(L) [plasma membrane] (Homo sapiens)
DISC:procaspase-8 [plasma membrane] (Homo sapiens)
DISC [plasma membrane] (Homo sapiens)
TRADD:TRAF2:RIPK1:FADD [cytosol] (Homo sapiens)
DISC:procaspase-8:FLIP(S) [plasma membrane] (Homo sapiens)
DISC:procaspase-8 [plasma membrane] (Homo sapiens)
DISC [plasma membrane] (Homo sapiens)
TRADD:TRAF2:RIPK1:FADD [cytosol] (Homo sapiens)
Regulation of necroptotic cell death (Homo sapiens)
CASP8 activity is inhibited (Homo sapiens)
FLIP(L) and procaspase-8 form heterodimer (Homo sapiens)
DISC:procaspase-8 [plasma membrane] (Homo sapiens)
DISC [plasma membrane] (Homo sapiens)
TRADD:TRAF2:RIPK1:FADD [cytosol] (Homo sapiens)
DISC:procaspase-8:FLIP(L) [plasma membrane] (Homo sapiens)
DISC:procaspase-8 [plasma membrane] (Homo sapiens)
DISC [plasma membrane] (Homo sapiens)
TRADD:TRAF2:RIPK1:FADD [cytosol] (Homo sapiens)
FLIP(S) and procaspase-8 form heterodimer (Homo sapiens)
DISC:procaspase-8 [plasma membrane] (Homo sapiens)
DISC [plasma membrane] (Homo sapiens)
TRADD:TRAF2:RIPK1:FADD [cytosol] (Homo sapiens)
DISC:procaspase-8:FLIP(S) [plasma membrane] (Homo sapiens)
DISC:procaspase-8 [plasma membrane] (Homo sapiens)
DISC [plasma membrane] (Homo sapiens)
TRADD:TRAF2:RIPK1:FADD [cytosol] (Homo sapiens)
RIPK1 is cleaved by CASP8 (Homo sapiens)
TRADD:TRAF2:RIPK1:FADD [cytosol] (Homo sapiens)
Signal Transduction (Homo sapiens)
Death Receptor Signaling (Homo sapiens)
TNF signaling (Homo sapiens)
Regulation of TNFR1 signaling (Homo sapiens)
Caspase-8 and FLIP(L) processing at TNFR signaling complex (Homo sapiens)
TRADD:TRAF2:RIP1:FADD:procaspase-8:FLIP(L) [cytosol] (Homo sapiens)
TRADD:TRAF2:RIPK1:FADD [cytosol] (Homo sapiens)
TRADD:TRAF2:RIPK1:FADD:p43/p41CASP8:p43 FLIP(L) [plasma membrane] (Homo sapiens)
TRADD:TRAF2:RIPK1:FADD [cytosol] (Homo sapiens)
FLIP(L) and procaspase-8 form heterodimer in TNF signaling (Homo sapiens)
TRADD:TRAF2:RIP1:FADD:procaspase-8:FLIP(L) [cytosol] (Homo sapiens)
TRADD:TRAF2:RIPK1:FADD [cytosol] (Homo sapiens)
TRADD:TRAF2:RIPK1:FADD [cytosol] (Homo sapiens)
RIPK1 is cleaved by CASP8 (Homo sapiens)
TRADD:TRAF2:RIPK1:FADD [cytosol] (Homo sapiens)
RIPK1 is cleaved by CASP8:FLIP(L) (Homo sapiens)
TRADD:TRAF2:RIPK1:FADD:p43/p41CASP8:p43 FLIP(L) [plasma membrane] (Homo sapiens)
TRADD:TRAF2:RIPK1:FADD [cytosol] (Homo sapiens)
TNFR1-induced proapoptotic signaling (Homo sapiens)
TRADD:TRAF2:RIP1 binds FADD (Homo sapiens)
TRADD:TRAF2:RIPK1:FADD [cytosol] (Homo sapiens)
TRADD:TRAF2:RIP1:FADD binds pro-caspase 8 (Homo sapiens)
TRADD:TRAF2:RIP1:FADD:CASP8(1-479) [cytosol] (Homo sapiens)
TRADD:TRAF2:RIPK1:FADD [cytosol] (Homo sapiens)
TRADD:TRAF2:RIPK1:FADD [cytosol] (Homo sapiens)
Literature References
PubMed ID
Title
Journal
Year
12721308
Fas-associated death domain protein and caspase-8 are not recruited to the tumor necrosis factor receptor 1 signaling complex during tumor necrosis factor-induced apoptosis
Cohen, GM
,
Hughes, M
,
Harper, N
,
MacFarlane, M
J. Biol. Chem.
2003
12887920
Induction of TNF receptor I-mediated apoptosis via two sequential signaling complexes
Micheau, O
,
Tschopp, J
Cell
2003
Participants
components
x 2
FADD [cytosol]
(Homo sapiens)
TRAF2:TRADD:RIPK1 [cytosol]
(Homo sapiens)
Participates
as a component of
TRADD:TRAF2:RIPK1:FADD:p43/p41CASP8:p43 FLIP(L) [plasma membrane] (Homo sapiens)
TRADD:TRAF2:RIP1:FADD:procaspase-8:FLIP(L) [cytosol] (Homo sapiens)
TRADD:TRAF2:RIP1:FADD:CASP8(1-479) [cytosol] (Homo sapiens)
TRAF2:TRADD:RIP1:FADD:2xCASP8(1-479) [cytosol] (Homo sapiens)
as an input of
FLIP(L) and procaspase-8 form heterodimer in TNF signaling (Homo sapiens)
RIPK1 is cleaved by CASP8 (Homo sapiens)
TRADD:TRAF2:RIP1:FADD binds pro-caspase 8 (Homo sapiens)
as an output of
TRADD:TRAF2:RIP1 binds FADD (Homo sapiens)
as a member of
DISC [plasma membrane] (Homo sapiens)
Inferred To
TRADD:TRAF2:RIPK1:FADD [cytosol]
(Bos taurus)
TRADD:TRAF2:RIPK1:FADD [cytosol]
(Canis familiaris)
TRADD:TRAF2:RIPK1:FADD [cytosol]
(Gallus gallus)
TRADD:TRAF2:RIPK1:FADD [cytosol]
(Mus musculus)
TRADD:TRAF2:RIPK1:FADD [cytosol]
(Rattus norvegicus)
TRADD:TRAF2:RIPK1:FADD [cytosol]
(Sus scrofa)
TRADD:TRAF2:RIPK1:FADD [cytosol]
(Xenopus tropicalis)
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