Activated thrombin:thrombomodulin cleaves PROCR:Protein C to PROCR:Activated protein C

Stable Identifier
R-HSA-141040
Type
Reaction [transition]
Species
Homo sapiens
Compartment
extracellular region, plasma membrane
Synonyms
protein C -> activated protein C + protein C heavy chain activation peptide
ReviewStatus
5/5
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Activated thrombin:thrombomodulin cleaves PROCR:Protein C to PROCR:Activated protein C
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Thrombin complexed with thrombomodulin at the endothelial cell surface cleaves the heavy chain of protein C, generating activated protein C and an activation peptide. The activation peptide has no known function.

Literature References
Participants
Input
Output
Participates
as an event of
Catalyst Activity

serine-type endopeptidase activity of activated thrombin:thrombomodulin [plasma membrane]

Physical Entity
activated thrombin:thrombomodulin [plasma membrane] (Homo sapiens)
Activity
serine-type endopeptidase activity (GO:0004252)
This event is regulated
Positively by
Regulator
Platelet Factor 4 [extracellular region] (Homo sapiens)
Orthologous Events
Activated thrombin:thrombomodulin cleaves PROCR:Protein C to PROCR:Activated protein C (Bos taurus)
Activated thrombin:thrombomodulin cleaves PROCR:Protein C to PROCR:Activated protein C (Canis familiaris)
Activated thrombin:thrombomodulin cleaves PROCR:Protein C to PROCR:Activated protein C (Mus musculus)
Activated thrombin:thrombomodulin cleaves PROCR:Protein C to PROCR:Activated protein C (Rattus norvegicus)
Activated thrombin:thrombomodulin cleaves PROCR:Protein C to PROCR:Activated protein C (Sus scrofa)
Authored
Ouwehand, WH  (2007-11-12)
Reviewed
Zwaginga, JJ  (2007-11-12)
Created
D'Eustachio, P  (2004-08-26)
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