Trimerization of TRAIL:TRAIL receptor complex

Stable Identifier
R-HSA-141139
Type
Reaction [binding]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
Trimerization of TNFSF10:TNFRSF10A,TNFRSF10B, Trimerization of TNFSF10:DR4,DR5
ReviewStatus
5/5
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Trimerization of TRAIL:TRAIL receptor complex
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The complex of TRAIL (TNFSF10) and TRAIL receptor-1 (TNFRSF10A) or TRAIL receptor-2 (TNFRSF10B) trimerizes (Sprick et al. 2000, Reis et al. 2011).
Literature References
PubMed ID Title Journal Year
10894160 FADD/MORT1 and caspase-8 are recruited to TRAIL receptors 1 and 2 and are essential for apoptosis mediated by TRAIL receptor 2

Juo, P, Blenis, J, Weigand, MA, Sprick, MR, Rauch, CT, Rieser, E, Walczak, H, Krammer, PH

Immunity 2000
20852190 Unraveling the binding mechanism of trivalent tumor necrosis factor ligands and their receptors

Reis, CR, van Assen, AH, Cool, RH, Quax, WJ

Mol. Cell Proteomics 2011
Participants
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Output
Participates
as an event of
Orthologous Events
Trimerization of TRAIL:TRAIL receptor complex (Gallus gallus)
Trimerization of TRAIL:TRAIL receptor complex (Mus musculus)
Trimerization of TRAIL:TRAIL receptor complex (Rattus norvegicus)
Reviewed
Salvesen, GS  (2013-05-22)
Pop, C  (2013-05-22)
Created
Tschopp, J  (2004-01-28)
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