PAO:FAD oxidises NASPM to PTCN

Stable Identifier
R-HSA-141348
Type
Reaction [transition]
Species
Homo sapiens
Compartment
ReviewStatus
5/5
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Acetylated spermidine (NASPM) is oxidised by the flavoenzyme polyamine oxidase (PAOX, with FAD as cofactor) to produce putrescine (PTCN). PAOX is involved in the back-conversion of polyamines and thus the regulation of their intracellular concentrations (Vujcic et al. 2003).
Literature References
PubMed ID Title Journal Year
12477380 Genomic identification and biochemical characterization of the mammalian polyamine oxidase involved in polyamine back-conversion

Diegelman, P, Vujcic, S, Kramer, DL, Porter, CW, Liang, P

Biochem J 2003
Participants
Participates
Catalyst Activity

N1-acetylspermidine:oxygen oxidoreductase (3-acetamidopropanal-forming) activity of PAOX:FAD [peroxisomal matrix]

Orthologous Events
Cross References
Rhea
Authored
Reviewed
Created
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