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Mad1 binds kinetochore
Stable Identifier
R-HSA-141409
Type
Reaction [binding]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
Cell Cycle (Homo sapiens)
Cell Cycle Checkpoints (Homo sapiens)
Mitotic Spindle Checkpoint (Homo sapiens)
Amplification of signal from the kinetochores (Homo sapiens)
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal (Homo sapiens)
Mad1 binds kinetochore (Homo sapiens)
General
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The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
The association of Mad1 with the kinetochore is the first step in the process of Mad2 mediated amplification of the signal from defective kinetochores.
Literature References
PubMed ID
Title
Journal
Year
11181178
Mitotic checkpoint proteins HsMAD1 and HsMAD2 are associated with nuclear pore complexes in interphase
Yen, TJ
,
Campbell, MS
,
Chan, GK
J Cell Sci
2001
Participants
Input
Kinetochore [cytosol]
(Homo sapiens)
MAD1L1 [cytosol]
(Homo sapiens)
Output
Mad1:kinetochore complex [cytosol]
(Homo sapiens)
Participates
as an event of
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal (Homo sapiens)
Orthologous Events
Mad1 binds kinetochore (Bos taurus)
Mad1 binds kinetochore (Canis familiaris)
Mad1 binds kinetochore (Gallus gallus)
Mad1 binds kinetochore (Mus musculus)
Mad1 binds kinetochore (Rattus norvegicus)
Mad1 binds kinetochore (Sus scrofa)
Mad1 binds kinetochore (Xenopus tropicalis)
Authored
Yen, TJ (2004-05-05)
Created
Yen, TJ (2004-05-05)
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