Reactome | BUB3 [cytosol]

BUB3 [cytosol]

Stable Identifier

R-HSA-141416

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Mitotic checkpoint protein BUB3

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Locations in the PathwayBrowser for interactor UniProt:P50991 CCT4

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Cell Cycle (Homo sapiens)

- Cell Cycle Checkpoints (Homo sapiens)
  - Mitotic Spindle Checkpoint (Homo sapiens)
    - Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components (Homo sapiens)
      - Inactivation of APC/C via direct inhibition of the APC/C complex (Homo sapiens)
        
        Formation of the MCC complex (Homo sapiens)
        
        BUB3 [cytosol] (Homo sapiens)
- Cell Cycle, Mitotic (Homo sapiens)
  - Regulation of mitotic cell cycle (Homo sapiens)
    - APC/C-mediated degradation of cell cycle proteins (Homo sapiens)
      - Regulation of APC/C activators between G1/S and early anaphase (Homo sapiens)
        
        Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components (Homo sapiens)
        
        Inactivation of APC/C via direct inhibition of the APC/C complex (Homo sapiens)
        
        Formation of the MCC complex (Homo sapiens)
        
        BUB3 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:O43684 BUB3

Gene Names

BUB3

Chain

chain:1-328

Reference Genes

BioGPS Gene:9184 BUB3

COSMIC (genes):BUB3 BUB3

CTD Gene:9184 BUB3

dbSNP Gene:9184 BUB3

ENSEMBL:ENSG00000154473 BUB3

ENSEMBL_homo_sapiens_GENE:ENSG00000154473.18 BUB3

HGNC:1151 BUB3

KEGG Gene (Homo sapiens):9184 BUB3

Monarch:9184 BUB3

NCBI Gene:9184 BUB3

OMIM:603719 BUB3

UCSC:O43684 BUB3

Reference Transcript

Other Identifiers

11721803_a_at

11721804_a_at

11747643_s_at

16710271

201456_PM_s_at

201456_s_at

201457_PM_x_at

201457_x_at

201458_PM_s_at

201458_s_at

209974_PM_s_at

209974_s_at

237245_3p_at

237245_PM_at

237245_at

3268670

3268672

3268673

3268674

3268675

3268676

3268677

3268678

3268679

3268683

3268684

3268685

3268686

3268687

3268688

3268701

3268703

3268705

34783_s_at

41547_at

56617_r_at

7931187

9184

A_14_P133496

A_14_P201360

A_23_P202316

A_23_P320658

A_23_P46924

GE54413

GE900467

GO:0000278

GO:0000775

GO:0000776

GO:0005515

GO:0005634

GO:0005654

GO:0005694

GO:0005829

GO:0007049

GO:0007059

GO:0007094

GO:0008608

GO:0022414

GO:0023052

GO:0033597

GO:0034501

GO:0043130

GO:0043226

GO:0051301

GO:0051321

GO:0051983

GO:0140014

GO:1990298

HMNXSV003047023

Hs.40323.0.S2_3p_a_at

Hs.86761.0.A1_3p_at

Hs.86761.0.A1_3p_x_at

ILMN_1693145

ILMN_1778764

ILMN_2245180

ILMN_2386100

PH_hs_0025098

TC10000900.hg

g3378103_3p_a_at

g3639059_3p_a_at

Participates

as a component of

as an input of

Formation of the MCC complex (Homo sapiens)

Inferred To

Bub3 [cytosol] (Drosophila melanogaster)

Bub3 [cytosol] (Mus musculus)

Ghost homologue of BUB3 [cytosol] (Rattus norvegicus)

bub-3 [cytosol] (Caenorhabditis elegans)

BUB3 [cytosol] (Bos taurus)

BUB3 [cytosol] (Canis familiaris)

BUB3 [cytosol] (Gallus gallus)

BUB3 [cytosol] (Saccharomyces cerevisiae)

BUB3 [cytosol] (Sus scrofa)

bub3 [cytosol] (Dictyostelium discoideum)

bub3 [cytosol] (Schizosaccharomyces pombe)

bub3 [cytosol] (Xenopus tropicalis)

Cross References

RefSeq

NP_001007794.1, NP_004716.1

OpenTargets

ENSG00000154473

GeneCards

O43684

HPA

ENSG00000154473-BUB3

Ensembl

ENSP00000357851, ENSG00000154473, ENSP00000357858, ENST00000368865, ENST00000368858

PRO

O43684

Pharos - Targets

O43684

Orphanet

22412

Interactors (14)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:O60566 BUB1B	1	BUB1B [cytosol] (R-HSA-141436)	0.932	13
UniProt:O43683 BUB1	1	BUB1 [cytosol] (R-HSA-377888)	0.801	8
UniProt:O43670 ZN207			0.692	5
UniProt:P54253 ATX1			0.666	7
UniProt:A0A0H3NF38 A0A0H3NF38			0.558	3
UniProt:O43586 PSTPIP1	1	PSTPIP1 [cytosol] (R-HSA-879220)	0.556	3
UniProt:Q9UJX2 CDC23	2	CDC23 [cytosol] (R-HSA-174137) CDC23 [nucleoplasm] (R-HSA-174228)	0.527	2
UniProt:P78371 CCT2	3	CCT2 [extracellular region] (R-HSA-6806220) CCT2 [azurophil granule lumen] (R-HSA-6799356) CCT2 [cytosol] (R-HSA-390464)	0.527	3
UniProt:Q9UJX5 ANAPC4	2	ANAPC4 [nucleoplasm] (R-HSA-174115) ANAPC4 [cytosol] (R-HSA-174168)	0.527	2
UniProt:P10636-8 MAPT	3	p-S199,S202,S262,S396,S404,S409,T181,T231-MAPT-8 [cytosol] (R-HSA-9836400) p-S262,S356,S396-MAPT-8 [cytosol] (R-HSA-9619521) MAPT-8 [cytosol] (R-HSA-9619519)	0.527	4
UniProt:Q12834 CDC20	3	CDC20 [cytosol] (R-HSA-141412) CDC20 [nucleoplasm] (R-HSA-174112) PolyUb-CDC20 [nucleoplasm] (R-HSA-6783069)	0.527	2
UniProt:P50991 CCT4	1	CCT4 [cytosol] (R-HSA-390458)	0.527	3
UniProt:P48643 CCT5	1	CCT5 [cytosol] (R-HSA-390447)	0.527	2
UniProt:Q9NQ48 LZTFL1	1	LZTFL1 [cytosol] (R-HSA-5617789)	0.508	2