Reactome | Formation of the MCC complex

Formation of the MCC complex

Stable Identifier

R-HSA-141437

Type

Reaction

Species

Homo sapiens

Compartment

cytosol

Locations in the PathwayBrowser

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Cell Cycle (Homo sapiens)

- Cell Cycle Checkpoints (Homo sapiens)
  - Mitotic Spindle Checkpoint (Homo sapiens)
    - Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components (Homo sapiens)
      - Inactivation of APC/C via direct inhibition of the APC/C complex (Homo sapiens)
        
        Formation of the MCC complex (Homo sapiens)
- Cell Cycle, Mitotic (Homo sapiens)
  - Regulation of mitotic cell cycle (Homo sapiens)
    - APC/C-mediated degradation of cell cycle proteins (Homo sapiens)
      - Regulation of APC/C activators between G1/S and early anaphase (Homo sapiens)
        
        Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components (Homo sapiens)
        
        Inactivation of APC/C via direct inhibition of the APC/C complex (Homo sapiens)
        
        Formation of the MCC complex (Homo sapiens)

General

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Upon release from the kinetochore, Mad2 associates with Cdc20, hBUBR1, and hBUB3 to form the Mitotic Checkpoint Complex (MCC). Assembly of this complex does not depend on kinetochores but this complex can only inhibit APC/C that has undergone mitotic modifications.

Literature References

PubMed ID	Title	Journal	Year
11535616	Checkpoint inhibition of the APC/C in HeLa cells is mediated by a complex of BUBR1, BUB3, CDC20, and MAD2 Yen, TJ, Sudakin, V, Chan, GK	J Cell Biol	2001