Reactome | CASP3(176-277) [cytosol]

CASP3(176-277) [cytosol]

Stable Identifier

R-HSA-141646

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Caspase-3 (small subunit)

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Literature References

PubMed ID	Title	Journal	Year
11931755	Mechanisms of caspase activation and inhibition during apoptosis Shi, Y	Mol Cell	2002

External Reference Information

External Reference

UniProt:P42574 CASP3

Gene Names

CASP3, CPP32

Chain

propeptide:1-9, propeptide:10-28, chain:29-175, chain:176-277

Reference Genes

BioGPS Gene:836 CASP3

COSMIC (genes):CASP3 CASP3

CTD Gene:836 CASP3

dbSNP Gene:836 CASP3

ENSEMBL:ENSG00000164305 CASP3

ENSEMBL_homo_sapiens_GENE:ENSG00000164305.20 CASP3

HGNC:1504 CASP3

KEGG Gene (Homo sapiens):836 CASP3

Monarch:836 CASP3

NCBI Gene:836 CASP3

OMIM:600636 CASP3

UCSC:P42574 CASP3

Reference Transcript

Other Identifiers

11717805_a_at

11719838_a_at

11719839_a_at

16982011

202763_PM_at

202763_at

2796488

2796489

2796490

2796491

2796492

2796494

2796495

2796496

2796497

2796500

2796502

2796504

2796505

2796506

2796507

36143_at

8103922

836

A_23_P92410

A_33_P3278118

GE58946

GO:0001554

GO:0001666

GO:0001782

GO:0001818

GO:0002020

GO:0002376

GO:0003824

GO:0004175

GO:0004190

GO:0004197

GO:0004861

GO:0005123

GO:0005515

GO:0005634

GO:0005654

GO:0005737

GO:0005829

GO:0005886

GO:0006508

GO:0006914

GO:0006915

GO:0006974

GO:0007155

GO:0007413

GO:0007507

GO:0007605

GO:0007611

GO:0008233

GO:0008234

GO:0008627

GO:0009410

GO:0009411

GO:0009611

GO:0009749

GO:0010033

GO:0010038

GO:0010165

GO:0012501

GO:0014070

GO:0016005

GO:0016241

GO:0016485

GO:0016787

GO:0021766

GO:0022414

GO:0023052

GO:0030154

GO:0030163

GO:0030182

GO:0030216

GO:0030218

GO:0030220

GO:0030889

GO:0031264

GO:0031647

GO:0032025

GO:0032355

GO:0032496

GO:0034349

GO:0034612

GO:0035094

GO:0035556

GO:0036211

GO:0042542

GO:0043025

GO:0043029

GO:0043065

GO:0043200

GO:0043226

GO:0043525

GO:0044346

GO:0044877

GO:0045165

GO:0045786

GO:0046007

GO:0048011

GO:0048856

GO:0050877

GO:0051146

GO:0051384

GO:0051402

GO:0051604

GO:0051716

GO:0061713

GO:0070269

GO:0071310

GO:0071407

GO:0071887

GO:0072734

GO:0097153

GO:0097190

GO:0097193

GO:0097194

GO:0097199

GO:0097200

GO:0098772

GO:0140096

GO:0140639

GO:1902004

GO:1904019

HMNXSV003052694

ILMN_1731639

ILMN_2388155

PH_hs_0022563

TC04001807.hg

U13737_at

g4757911_3p_at

Participates

as a component of

CASP3(29-175):CASP3(176-277) [cytosol] (Homo sapiens)

Other forms of this molecule

CASP3(1-277) [cytosol]

CASP3(29-175) [nucleoplasm]

CASP3(176-277) [nucleoplasm]

CASP3(29-175) [cytosol]

Inferred To

Caspase-3 subunit p12 [cytosol] (Mus musculus)

Drice [cytosol] (Drosophila melanogaster)

CASP3 [cytosol] (Bos taurus)

CASP3 [cytosol] (Canis familiaris)

CASP3 [cytosol] (Gallus gallus)

Casp3 [cytosol] (Rattus norvegicus)

casp3.2 [cytosol] (Xenopus tropicalis)

casp3a [cytosol] (Danio rerio)

CASP3(176-277) [cytosol] (Sus scrofa)

ced-3 [cytosol] (Caenorhabditis elegans)

Cross References

RefSeq

NP_116786.1, NP_004337.2, XP_011530603.1

ZINC - World Drugs

CASP3_HUMAN

Guide to Pharmacology - Targets

1619

OpenTargets

ENSG00000164305

ZINC - FDA approved

CASP3_HUMAN

ZINC - Substances

CASP3_HUMAN

ZINC - Biogenic

CASP3_HUMAN

ZINC target

P42574

PRO

P42574

PDB

3ITN, 2CNN, 5I9B, 4QU9, 4QUH, 2Y0B, 1CP3, 5IAR, 2XZT, 4JR0, 4JQY, 3EDQ, 7XN5, 4PRY, 5IAK, 4QUB, 3PCX, 1RE1, 5IBC, 4QUJ, 1NMS, 5IAB, 2XYP, 3GJS, 4QU5, 4EHN, 4QTY, 4EHK, 5IC4, 4DCP, 3DEH, 2C1E, 3DEJ, 2C2O, 3GJQ, 2CNL, 2CJX, 2C2K, 2J32, 4PS0, 2XYG, 4EHF, 5IAG, 2J30, 3PD1, 3KJF, 2H5J, 4EHA, 1NME, 5IAS, 4QUI, 2CNO, 4QU8, 1RHR, 2DKO, 4QUG, 2CDR, 4JQZ, 1RHU, 5IAN, 5IBP, 7XN6, 4QUD, 4DCJ, 1GFW, 5IAJ, 5I9T, 7XN4, 1NMQ, 4QUA, 2H5I, 4QUL, 3PD0, 1I3O, 3GJT, 3DEK, 4JJE, 4EHL, 1PAU, 4QU0, 2CNK, 3DEI, 4DCO, 3GJR, 2C2M, 4QUE, 2CJY, 5IBR, 4QTX, 4EHH, 1RHM, 1QX3, 2J33, 1RHQ, 2XYH, 2H65, 2J31, 2XZD, 1RHJ, 3H0E, 4EHD, 5IAE, 1RHK

ZINC - Investigational

CASP3_HUMAN

IntEnz

3.4.22.56

GeneCards

P42574

HPA

ENSG00000164305-CASP3

Ensembl

ENSP00000311032, ENST00000700100, ENST00000700101, ENST00000523916, ENSP00000428929, ENSG00000164305, ENSP00000514797, ENST00000308394, ENSP00000514798

Pharos - Targets

P42574

ZINC - Predictions - Purchasable

CASP3_HUMAN

Interactors (12)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P98170 XIAP	3	XIAP [nucleoplasm] (R-HSA-3322366) K48pUb-XIAP [cytosol] (R-HSA-5675477) XIAP [cytosol] (R-HSA-50849)	0.872	7
UniProt:P10599 TXN	4	2xHC-TXN [nucleoplasm] (R-HSA-9617733) TXN [nucleoplasm] (R-HSA-9617732) 2xHC-TXN [cytosol] (R-HSA-73668) TXN [cytosol] (R-HSA-66000)	0.672	6
UniProt:P05067 APP	20	APP(18-770) [trans-Golgi network membrane] (R-HSA-5229136) APP-C99 [cytosol] (R-HSA-9617603) APP(18-770) [extracellular region] (R-HSA-49335) APP(18-770) [platelet alpha granule lumen] (R-HSA-139835) APP(18-687) [extracellular region] (R-HSA-9010033) APP(688-770) [plasma membrane] (R-HSA-9010028) APP(18-770) [Golgi lumen] (R-HSA-8871509) APP(18-770) [plasma membrane] (R-HSA-9010038) APP(18-671) [endosome lumen] (R-HSA-5693003) APP(714-770) [endosome lumen] (R-HSA-6783325) APP(712-770) [endosome lumen] (R-HSA-6783331) APP(672-770) [endosome lumen] (R-HSA-9010082) APP(672-713) [endosome lumen] (R-HSA-5692993) APP(672-711) [endosome lumen] (R-HSA-6783333) APP(18-770) [endosome lumen] (R-HSA-5229077) p-APP [endoplasmic reticulum lumen] (R-HSA-8957012) APP [endoplasmic reticulum lumen] (R-HSA-8956696) APP(672-711) [extracellular region] (R-HSA-976740) APP(672-711) [cytosol] (R-HSA-877188) APP(672-713) [extracellular region] (R-HSA-879340)	0.659	4
UniProt:O14727 APAF1	4	APAF1 [secretory granule lumen] (R-HSA-6801271) APAF1 [extracellular region] (R-HSA-6806465) APAF1 [ficolin-1-rich granule lumen] (R-HSA-6801301) APAF1 [cytosol] (R-HSA-50099)	0.653	7
UniProt:P55211 CASP9	5	p-S196-CASP9(1-416) [cytosol] (R-HSA-198636) p-T412-CASP9(1-416) [cytosol] (R-HSA-9627087) CASP9(331-416) [cytosol] (R-HSA-141639) CASP9(?-315) [cytosol] (R-HSA-141638) CASP9(1-416) [cytosol] (R-HSA-57033)	0.644	3
UniProt:P09874 PARP1	4	polySUMO2,3-K203,K486-PARP1 [nucleoplasm] (R-HSA-4551617) monoSUMO1-K203,K486-PARP1 [nucleoplasm] (R-HSA-4551686) PAR-PARP1 [nucleoplasm] (R-HSA-5651713) PARP1 [nucleoplasm] (R-HSA-201568)	0.623	2
UniProt:O60551 NMT2	1	NMT2 [cytosol] (R-HSA-184377)	0.609	2
UniProt:Q9Y243 AKT3	6	p-T305-AKT3 [cytosol] (R-HSA-3009370) AKT3 [cytosol] (R-HSA-2976007) AKT3 [plasma membrane] (R-HSA-2976006) p-S472-AKT3 [plasma membrane] (R-HSA-3009363) p-T305,S472-AKT3 [cytosol] (R-HSA-3009367) p-T305,S472-AKT3 [nucleoplasm] (R-HSA-3009365)	0.571	2
UniProt:Q00987 MDM2	11	PolyUb-MDM2 [nucleoplasm] (R-HSA-6782472) monoSUMO1-K182-MDM2 [nucleoplasm] (R-HSA-3000408) MDM2 [plasma membrane] (R-HSA-416843) MDM2 [endocytic vesicle membrane] (R-HSA-416849) p-5S,T-MDM2 [nucleoplasm] (R-HSA-6804954) PolyUb,p-S166,S188-MDM2 [nucleoplasm] (R-HSA-6795669) p-S166,S188,T218-MDM2 [nucleoplasm] (R-HSA-6792862) MDM2 [nucleoplasm] (R-HSA-69486) MDM2 [cytosol] (R-HSA-198644) p-S166,S188-MDM2 [cytosol] (R-HSA-198638) p-S166,S188-MDM2 [nucleoplasm] (R-HSA-6793669)	0.571	2
UniProt:P55212 CASP6	5	CASP6 (1-293) [cytosol] (R-HSA-6798132) CASP6(194-293) [nucleoplasm] (R-HSA-352246) CASP6(24-179) [nucleoplasm] (R-HSA-352247) CASP6(24-179) [cytosol] (R-HSA-350313) CASP6(194-293) [cytosol] (R-HSA-266128)	0.571	2
UniProt:P54252 ATXN3	2	ATXN3 [nucleoplasm] (R-HSA-6783285) ATXN3 [cytosol] (R-HSA-5625607)	0.556	9
UniProt:P42858 HTT	1	HTT [nucleoplasm] (R-HSA-9023590)	0.556	9