Reactome | INSR(28-758) [endosome membrane]

INSR(28-758) [endosome membrane]

Stable Identifier

R-HSA-141718

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

endosome membrane

Synonyms

Insulin receptor alpha subunit, INSR

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External Reference Information

External Reference

UniProt:P06213 INSR

Gene Names

INSR

Chain

signal peptide:1-27, chain:28-758, chain:763-1382

Reference Genes

BioGPS Gene:3643 INSR

COSMIC (genes):INSR INSR

CTD Gene:3643 INSR

dbSNP Gene:3643 INSR

ENSEMBL:ENSG00000171105 INSR

ENSEMBL_homo_sapiens_GENE:ENSG00000171105.14 INSR

HGNC:6091 INSR

KEGG Gene (Homo sapiens):3643 INSR

Monarch:3643 INSR

NCBI Gene:3643 INSR

OMIM:147670 INSR

UCSC:P06213 INSR

Reference Transcript

Other Identifiers

11720856_a_at

11720857_a_at

11720858_a_at

11740017_a_at

11740018_a_at

1572_s_at

16867915

207851_PM_s_at

207851_s_at

213792_PM_s_at

213792_s_at

226212_PM_s_at

226212_s_at

226216_PM_at

226216_at

226450_PM_at

226450_at

33162_at

3643

3848249

3848250

3848251

3848252

3848253

3848254

3848255

3848256

3848257

3848258

3848259

3848260

3848262

3848263

3848264

3848266

3848267

3848268

3848269

3848270

3848271

3848273

3848278

3848279

3848280

3848281

3848282

3848288

3848292

3848293

3848294

3848296

3848297

3848299

3848301

3848303

3848304

3848308

3848341

3848349

3848350

47628_at

65110_at

8033362

A_23_P4764

A_33_P3335725

GE59638

GO:0000166

GO:0000278

GO:0001540

GO:0001934

GO:0002092

GO:0003007

GO:0003013

GO:0003824

GO:0004672

GO:0004713

GO:0004714

GO:0005009

GO:0005159

GO:0005515

GO:0005524

GO:0005525

GO:0005576

GO:0005615

GO:0005634

GO:0005635

GO:0005764

GO:0005768

GO:0005770

GO:0005773

GO:0005886

GO:0005899

GO:0005901

GO:0005975

GO:0006091

GO:0006351

GO:0006355

GO:0006468

GO:0006898

GO:0007169

GO:0007186

GO:0007612

GO:0007613

GO:0008284

GO:0008286

GO:0008544

GO:0008584

GO:0009887

GO:0009897

GO:0010008

GO:0016020

GO:0016192

GO:0016301

GO:0016310

GO:0016740

GO:0018108

GO:0019904

GO:0022414

GO:0023052

GO:0030238

GO:0030325

GO:0030335

GO:0030424

GO:0031017

GO:0031410

GO:0031623

GO:0031981

GO:0031994

GO:0031995

GO:0032147

GO:0032148

GO:0032590

GO:0032809

GO:0032869

GO:0034330

GO:0036211

GO:0038024

GO:0042593

GO:0042802

GO:0043226

GO:0043235

GO:0043243

GO:0043406

GO:0043410

GO:0043548

GO:0043559

GO:0043560

GO:0044877

GO:0045429

GO:0045725

GO:0045821

GO:0045840

GO:0045893

GO:0045995

GO:0046326

GO:0046718

GO:0046777

GO:0048639

GO:0048856

GO:0048870

GO:0050877

GO:0051425

GO:0051446

GO:0051897

GO:0055085

GO:0055086

GO:0060089

GO:0060267

GO:0070062

GO:0071363

GO:0097062

GO:0097242

GO:0140014

GO:0140096

GO:0150104

GO:1901135

GO:1990535

GO:2000194

HMNXSV003020236

Hs.208334.0.S1_3p_at

Hs.208334.0.S2_3p_s_at

Hs.89695.2.A1_3p_at

Hs.98401.0.S1_3p_at

ILMN_1670918

M10051_s_at

PH_hs_0025683

TC19001111.hg

X02160_at

g4557883_3p_a_at

Participates

as a component of

Other forms of this molecule

p-6Y-INSR(763-1382) [endosome membrane]

INSR(763-1382) [endosome membrane]

INSR(763-1382) [plasma membrane]

p-6Y-INSR(763-1382) [plasma membrane]

INSR(28-758) [plasma membrane]

Inferred To

INSR [endosome membrane] (Canis familiaris)

INSR [endosome membrane] (Gallus gallus)

INSR(28-758) [endosome membrane] (Bos taurus)

INSR(28-758) [endosome membrane] (Caenorhabditis elegans)

INSR(28-758) [endosome membrane] (Danio rerio)

INSR(28-758) [endosome membrane] (Drosophila melanogaster)

INSR(28-758) [endosome membrane] (Mus musculus)

INSR(28-758) [endosome membrane] (Rattus norvegicus)

INSR(28-758) [endosome membrane] (Sus scrofa)

INSR(28-758) [endosome membrane] (Xenopus tropicalis)

Cross References

RefSeq

NP_001073285.1, NP_000199.2

ZINC - World Drugs

INSR_HUMAN

Guide to Pharmacology - Targets

1800

OpenTargets

ENSG00000171105

ZINC - FDA approved

INSR_HUMAN

ZINC - Substances

INSR_HUMAN

ZINC - Biogenic

INSR_HUMAN

ZINC target

P06213

PRO

P06213

PDB

7YQ4, 8GUY, 3BU6, 7PHT, 5J3H, 8DWN, 2B4S, 1GAG, 7U6E, 7PG2, 5HHW, 4ZXB, 7QID, 6VEP, 2HR7, 1IR3, 6PXV, 6HN4, 4OGA, 5U1M, 3EKN, 1P14, 7PG3, 6SOF, 7PG4, 7YQ5, 7YQ6, 3ETA, 2AUH, 7MQR, 3W13, 7BW8, 4IBM, 4XST, 7S0Q, 3W12, 2MFR, 7S8V, 7YQ3, 7BW7, 7MQO, 4XSS, 5E1S, 7PG0, 3W11, 5KQV, 3EKK, 6PXW, 7BWA, 2Z8C, 7KD6, 7MQS, 7U6D, 1IRK, 3BU5, 6HN5, 1RQQ, 1I44, 4XLV, 3BU3, 6VEQ

ZINC - Investigational

INSR_HUMAN

ZINC - Metabolites

INSR_HUMAN

GeneCards

P06213

HPA

ENSG00000171105-INSR

Ensembl

ENST00000302850, ENST00000341500, ENSP00000303830, ENSG00000171105, ENSP00000342838

Pharos - Targets

P06213

ZINC - Predictions - Purchasable

INSR_HUMAN

Orphanet

16263

HMDB Protein

HMDBP01521

Interactors (13)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P18031 PTPN1	2	PTPN1 [cytosol] (R-HSA-210625) PTPN1 [endosome membrane] (R-HSA-9815895)	0.98	33
UniProt:P19174 PLCG1	6	p-Y-PLCG1 [cytosol] (R-HSA-9029082) p-4Y-PLCG1 [plasma membrane] (R-HSA-167679) PLCG1 [cytosol] (R-HSA-202320) PLCG1 [plasma membrane] (R-HSA-167682) p-Y771,Y783,Y1254-PLCG1 [cytosol] (R-HSA-202357) p-Y771,Y783-PLCG1 [plasma membrane] (R-HSA-1169084)	0.799	9
UniProt:P35570 Irs1	7	Irs1 [cytosol] (R-RNO-1168867) phospho-Irs1 [plasma membrane] (R-RNO-2445090) Irs1 [plasma membrane] (R-RNO-2425392) p-Y-Irs1 [cytosol] (R-RNO-112362) Irs1 [cytosol] (R-RNO-74769) phospho-Irs1 [cytosol] (R-RNO-74772) phospho-Irs1 [plasma membrane] (R-RNO-198366)	0.791	5
UniProt:P27986 PIK3R1	16	p-Y-PIK3R1 [cytosol] (R-HSA-9680647) PIK3R1 G376R [plasma membrane] (R-HSA-2399717) PIK3R1 K379E [plasma membrane] (R-HSA-8944148) PIK3R1 Y463_L466del [plasma membrane] (R-HSA-2399546) PIK3R1 H450_E451del [plasma membrane] (R-HSA-2399545) PIK3R1 R574_T576del [plasma membrane] (R-HSA-2399544) PIK3R1 D560Y [plasma membrane] (R-HSA-2399421) PIK3R1 N564D [plasma membrane] (R-HSA-2399427) PIK3R1 K459del [plasma membrane] (R-HSA-2399554) PIK3R1 N564K [plasma membrane] (R-HSA-2399431) PIK3R1 D560H [plasma membrane] (R-HSA-2399432) PIK3R1 R574I [plasma membrane] (R-HSA-2399536) PIK3R1 R574T [plasma membrane] (R-HSA-2399540) K63polyUb-PIK3R1 [cytosol] (R-HSA-3080572) PIK3R1 [cytosol] (R-HSA-74789) PIK3R1 [plasma membrane] (R-HSA-198365)	0.767	5
UniProt:P35568 IRS1	5	p-Y-IRS1 [plasma membrane] (R-HSA-198366) p-Y-IRS1 [cytosol] (R-HSA-74772) IRS1 [cytosol] (R-HSA-74769) IRS1 [plasma membrane] (R-HSA-2425392) p-6Y-IRS1 [plasma membrane] (R-HSA-2445090)	0.704	5
UniProt:Q13257 MAD2L1	2	MAD2L1 [cytosol] (R-HSA-141400) Activated MAD2L1 [cytosol] (R-HSA-141447)	0.701	4
UniProt:Q06124 PTPN11	4	p-Y542-PTPN11 [cytosol] (R-HSA-1369081) PTPN11 [nucleoplasm] (R-HSA-8937745) PTPN11 [cytosol] (R-HSA-162563) p-Y542,Y580-PTPN11 [cytosol] (R-HSA-162573)	0.65	3
UniProt:Q15262 PTPRK	1	PTPRK [plasma membrane] (R-HSA-6785699)	0.59	2
UniProt:Q13322 GRB10	2	p-Y GRB10 [cytosol] (R-HSA-9706168) GRB10 [cytosol] (R-HSA-110009)	0.581	4
UniProt:P29353 SHC1	5	p-Y427-SHC1 [cytosol] (R-HSA-74684) p-Y349,Y350-SHC1 [cytosol] (R-HSA-180276) p-Y349,Y350,Y427-SHC1 [cytosol] (R-HSA-912321) SHC1 [cytosol] (R-HSA-74680) p-Y-SHC1 [cytosol] (R-HSA-162568)	0.573	2
UniProt:Q9Y4L1 HYOU1	3	HYOU1 [extracellular region] (R-HSA-3221939) HYOU1 [endocytic vesicle lumen] (R-HSA-3221924) HYOU1 [endoplasmic reticulum lumen] (R-HSA-535542)	0.569	3
UniProt:Q9Y4H2 IRS2	4	IRS2 [plasma membrane] (R-HSA-2428927) IRS2 [cytosol] (R-HSA-57528) p-Y-IRS2 [cytosol] (R-HSA-74774) p-Y-IRS2 [plasma membrane] (R-HSA-198334)	0.527	4
UniProt:Q99490 AGAP2	1	AGAP2 [cytosol] (R-HSA-622355)	0.524	2

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