Dimerization of sSCF

Stable Identifier
R-HSA-1433395
Type
Reaction [binding]
Species
Homo sapiens
Compartment
ReviewStatus
5/5
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sSCF exists as noncovalently associated homodimer composed of two monomers interacting head-to-head to form an elongated, slightly bent dimer. Dimerization of sSCF is a dynamic process and it may play a regulatory role in the dimerization and activation of KIT (Zhang et al, 2000; Philo et al, 1996).
Literature References
PubMed ID Title Journal Year
8636116 Human stem cell factor dimer forms a complex with two molecules of the extracellular domain of its receptor, Kit

Wypych, J, Schwartz, MG, Langley, KE, Wen, J, Mendiaz, EA, Philo, JS

J Biol Chem 1996
10884405 Crystal structure of human stem cell factor: implication for stem cell factor receptor dimerization and activation

Schlessinger, J, Zhang, Z, Joachimiak, A, Kong, XP, Zhang, R

Proc Natl Acad Sci U S A 2000
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