Activation of RAC1

Stable Identifier
R-HSA-1433415
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol, plasma membrane
ReviewStatus
5/5
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Activation of RAC1
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Vav1, once activated by PIP3 binding and phosphorylation by Src kinases, stimulates the GDP/GTP exchange activity of Rac. Vav1 is selective for Rac and catalyses exchange of bound GDP for GTP.
Literature References
PubMed ID Title Journal Year
9799234 Kit signaling through PI 3-kinase and Src kinase pathways: an essential role for Rac1 and JNK activation in mast cell proliferation

Timokhina, I, Stella, G, Kissel, H, Besmer, P

EMBO J 1998
8990121 Phosphotyrosine-dependent activation of Rac-1 GDP/GTP exchange by the vav proto-oncogene product

Ostrom, AA, Bustelo, XR, Gutkind, JS, Crespo, P, Schuebel, KE

Nature 1997
Participants
Input
Output
Participates
as an event of
Catalyst Activity

guanyl-nucleotide exchange factor activity of p-VAV1:PIP3 [plasma membrane]

Physical Entity
p-VAV1:PIP3 [plasma membrane] (Homo sapiens)
Activity
guanyl-nucleotide exchange factor activity (GO:0005085)
Orthologous Events
Activation of RAC1 (Bos taurus)
Activation of RAC1 (Caenorhabditis elegans)
Activation of RAC1 (Canis familiaris)
Activation of RAC1 (Drosophila melanogaster)
Activation of RAC1 (Mus musculus)
Activation of RAC1 (Rattus norvegicus)
Activation of RAC1 (Sus scrofa)
Activation of RAC1 (Xenopus tropicalis)
Authored
Garapati, P V  (2011-07-11)
Reviewed
Rönnstrand, L  (2011-08-22)
Created
Garapati, P V  (2011-07-11)
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