Reactome | Phosphorylation of JAK2

Phosphorylation of JAK2

Stable Identifier

R-HSA-1433418

Type

Reaction [transition]

Species

Homo sapiens

Compartment

plasma membrane, cytosol, extracellular region

ReviewStatus

5/5

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SCF induces rapid and transient autophosphorylation of JAK2 bound to c-KIT. JAKs bound to activated, dimerized receptors cross-phosphorylate and thereby activate each other. Multiple phosphorylation sites have been identified in JAK2 (tyrosines 221, 570, 868, 966, 972, 1007 and 1008 ). Phosphorylation of tyrosine 1007 is essential for kinase activity (Feng et al 1997, Argetsinger et al. 2004, 2010). Tyrosine 1007 is in the activation loop and phosphorylation allows access of the catalytic loop to the ATP in the ATP binding domain. Of all the predicted phoshorylation sites only the critical tyrosine 1007 is represented in the reaction.

Literature References

PubMed ID	Title	Journal	Year
9111318	Activation of Jak2 catalytic activity requires phosphorylation of Y1007 in the kinase activation loop Matsuda, T, Witthuhn, BA, Kerr, IM, Kohlhuber, F, Feng, J, Ihle, JN	Mol Cell Biol	1997
15143187	Autophosphorylation of JAK2 on tyrosines 221 and 570 regulates its activity Steen, H, Carter-Su, C, Argetsinger, LS, Jensen, ON, Kouadio, JL, Stensballe, A	Mol Cell Biol	2004
8611693	JAK2 is associated with the c-kit proto-oncogene product and is phosphorylated in response to stem cell factor Keller, JR, Linnekin, D, Longo, DL, Mou, S, Ruscetti, FW, Ferris, DK, DeBerry, CS, Weiler, SR	Blood	1996
20304997	Tyrosines 868, 966, and 972 in the kinase domain of JAK2 are autophosphorylated and required for maximal JAK2 kinase activity Carter-Su, C, Marto, JA, Cline, JM, Argetsinger, LS, Koleva, RI, Robertson, SA, Stuckey, JA, Myers MG, Jr	Mol Endocrinol	2010