Reactome | JAK2 binds to p-KIT

JAK2 binds to p-KIT

Stable Identifier

R-HSA-1433451

Type

Reaction [binding]

Species

Homo sapiens

Compartment

plasma membrane, cytosol, extracellular region

ReviewStatus

5/5

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Janus kinase 2 (JAK2) plays an important role in SCF-induced proliferation (Radosevic et al. 2004). JAK2 was observed to pre-associate with KIT, with increased association after SCF stimulation of KIT (Weiler et al. 1996).

Literature References

PubMed ID	Title	Journal	Year
8611693	JAK2 is associated with the c-kit proto-oncogene product and is phosphorylated in response to stem cell factor Keller, JR, Linnekin, D, Longo, DL, Mou, S, Ruscetti, FW, Ferris, DK, DeBerry, CS, Weiler, SR	Blood	1996