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MATK [cytosol]
Stable Identifier
R-HSA-1433581
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
CHK, Megakaryocyte-associated tyrosine-protein kinase, MATK_HUMAN, Csk homologous kinase
Locations in the PathwayBrowser
Expand all
Signal Transduction (Homo sapiens)
Signaling by Receptor Tyrosine Kinases (Homo sapiens)
Signaling by ERBB2 (Homo sapiens)
Downregulation of ERBB2 signaling (Homo sapiens)
MATK (CSK homologous kinase) binds phosphorylated ERBB2 (Homo sapiens)
MATK [cytosol] (Homo sapiens)
p-ERBB2 heterodimers:MATK [plasma membrane] (Homo sapiens)
MATK [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:P42679 MATK
Gene Names
MATK, CTK, HYL
Chain
chain:1-507
Reference Genes
BioGPS Gene:4145 MATK
COSMIC (genes):MATK MATK
CTD Gene:4145 MATK
dbSNP Gene:4145 MATK
ENSEMBL:ENSG00000007264 MATK
ENSEMBL_homo_sapiens_GENE:ENSG00000007264.15 MATK
HGNC:6906 MATK
KEGG Gene (Homo sapiens):4145 MATK
Monarch:4145 MATK
NCBI Gene:4145 MATK
OMIM:600038 MATK
UCSC:P42679 MATK
Reference Transcript
RefSeq:NM_002378.3 MATK
RefSeq:NM_139355.2 MATK
RefSeq:NM_139354.2 MATK
RefSeq:XM_011528018.1 MATK
Other Identifiers
11731227_a_at
16867153
206267_PM_s_at
206267_s_at
36264_at
3846404
3846405
3846406
3846407
3846409
3846412
3846414
3846416
3846417
3846418
3846422
3846425
3846426
3846427
3846429
3846430
3846431
3846433
3846435
3846436
3846438
3846440
3846442
4145
8032682
A_23_P50678
GE88095
GO:0000166
GO:0003824
GO:0004672
GO:0004713
GO:0004715
GO:0005515
GO:0005524
GO:0005737
GO:0005829
GO:0006468
GO:0008284
GO:0016020
GO:0016301
GO:0016310
GO:0016740
GO:0036211
GO:0140096
HMNXSV003019498
ILMN_1669321
ILMN_1803615
ILMN_2319000
PH_hs_0025640
S75168_rna1_at
TC19001051.hg
g4505108_3p_a_at
Participates
as a component of
p-ERBB2 heterodimers:MATK [plasma membrane] (Homo sapiens)
as an input of
MATK (CSK homologous kinase) binds phosphorylated ERBB2 (Homo sapiens)
Inferred To
MATK [cytosol]
(Bos taurus)
MATK [cytosol]
(Caenorhabditis elegans)
MATK [cytosol]
(Canis familiaris)
MATK [cytosol]
(Drosophila melanogaster)
MATK [cytosol]
(Gallus gallus)
MATK [cytosol]
(Mus musculus)
MATK [cytosol]
(Rattus norvegicus)
MATK [cytosol]
(Sus scrofa)
Homologues of MATK [cytosol]
(Caenorhabditis elegans)
Cross References
RefSeq
NP_002369.2
,
XP_011526320.1
,
NP_647611.1
,
NP_647612.1
ZINC - World Drugs
MATK_HUMAN
Guide to Pharmacology - Targets
2101
OpenTargets
ENSG00000007264
ZINC - FDA approved
MATK_HUMAN
ZINC - Substances
MATK_HUMAN
ZINC target
P42679
ZINC - Biogenic
MATK_HUMAN
PRO
P42679
PDB
3US4
,
1JWO
,
1X6G
ZINC - Investigational
MATK_HUMAN
GeneCards
P42679
HPA
ENSG00000007264-MATK
Ensembl
ENST00000395040
,
ENSP00000308734
,
ENSP00000378481
,
ENST00000310132
,
ENST00000395045
,
ENSG00000007264
,
ENSP00000378485
,
ENST00000619596
,
ENSP00000483213
Pharos - Targets
P42679
ZINC - Predictions - Purchasable
MATK_HUMAN
Interactors (7)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q5S007 LRRK2
1
LRRK2 [cytosol]
(R-HSA-5661173)
0.623
2
UniProt:P04626 ERBB2
20
ERBB2 G309E [plasma membrane]
(R-HSA-9665342)
ERBB2 G309A [plasma membrane]
(R-HSA-9665349)
ERBB2 S310F [plasma membrane]
(R-HSA-9665350)
ERBB2 S310Y [plasma membrane]
(R-HSA-9665344)
p-6Y-ERBB2 G309A [plasma membrane]
(R-HSA-9665381)
p-6Y-ERBB2 G309E [plasma membrane]
(R-HSA-9665382)
p-6Y-ERBB2 S310F [plasma membrane]
(R-HSA-9665379)
p-6Y-ERBB2 S310Y [plasma membrane]
(R-HSA-9665385)
p-Y-ERBB2 L755P [plasma membrane]
(R-HSA-9654268)
p-Y-ERBB2 I767M [plasma membrane]
(R-HSA-9654303)
p-Y-ERBB2 T798I [plasma membrane]
(R-HSA-9654618)
p-Y-ERBB2 Y772_A775dup [plasma membrane]
(R-HSA-9665652)
p-Y-ERBB2 T862A [plasma membrane]
(R-HSA-9654695)
p-Y-ERBB2 T798M [plasma membrane]
(R-HSA-9654615)
p-Y-ERBB2 H878Y [plasma membrane]
(R-HSA-9654833)
p-Y-ERBB2 V777L [plasma membrane]
(R-HSA-9654401)
p-Y-ERBB2 L755S [plasma membrane]
(R-HSA-9654194)
p-Y-ERBB2 V777E [plasma membrane]
(R-HSA-9654397)
p-Y-ERBB2 V777M [plasma membrane]
(R-HSA-9654398)
p-Y-ERBB2 L755M [plasma membrane]
(R-HSA-9654191)
0.59
2
UniProt:Q9Y5Z0 BACE2
0.556
3
UniProt:Q92876 KLK6
0.556
3
UniProt:P08238 HSP90AB1
6
HSP90AB1 [secretory granule lumen]
(R-HSA-6801477)
HSP90AB1 [extracellular region]
(R-HSA-6806463)
HSP90AB1 [ficolin-1-rich granule lumen]
(R-HSA-6801491)
HSP90AB1 [cytosol]
(R-HSA-419617)
HSP90AB1 [nucleoplasm]
(R-HSA-5082399)
HSP90AB1 [lysosomal lumen]
(R-HSA-9622846)
0.524
2
UniProt:O43559 FRS3
3
p-5Y-FRS3 [plasma membrane]
(R-HSA-191475)
FRS3 [plasma membrane]
(R-HSA-191482)
p-Y-FRS3 [plasma membrane]
(R-HSA-9032427)
0.488
2
UniProt:Q14289 PTK2B
3
p-Y-PTK2B [cytosol]
(R-HSA-508515)
PTK2B [cytosol]
(R-HSA-390932)
PTK2B [cytosol]
(R-HSA-5218721)
0.462
2
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