Reactome | GSPT2 [cytosol]

GSPT2 [cytosol]

Stable Identifier

R-HSA-143379

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

eRF3

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Metabolism of RNA (Homo sapiens)

- Nonsense-Mediated Decay (NMD) (Homo sapiens)
  - Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) (Homo sapiens)
    - SMG1 phosphorylates UPF1 (enhanced by Exon Junction Complex) (Homo sapiens)
      - SMG1:Phosphorylated UPF1:EJC:Translated mRNP [cytosol] (Homo sapiens)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Homo sapiens)
        
        eRF3:GDP [cytosol] (Homo sapiens)
        
        eRF3 [cytosol] (Homo sapiens)
        
        GSPT2 [cytosol] (Homo sapiens)
      - SMG1:UPF1:EJC:Translated mRNP [cytosol] (Homo sapiens)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Homo sapiens)
        
        eRF3:GDP [cytosol] (Homo sapiens)
        
        eRF3 [cytosol] (Homo sapiens)
        
        GSPT2 [cytosol] (Homo sapiens)
    - SMG6 hydrolyzes mRNA with premature termination codon (Homo sapiens)
      - Phosphorylated UPF1:SMG5:SMG7:SMG6:PP2A:Translated mRNP [cytosol] (Homo sapiens)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Homo sapiens)
        
        eRF3:GDP [cytosol] (Homo sapiens)
        
        eRF3 [cytosol] (Homo sapiens)
        
        GSPT2 [cytosol] (Homo sapiens)
    - UPF1 binds an mRNP with a termination codon preceding an Exon Junction Complex (Homo sapiens)
      - SMG1:UPF1:EJC:Translated mRNP [cytosol] (Homo sapiens)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Homo sapiens)
        
        eRF3:GDP [cytosol] (Homo sapiens)
        
        eRF3 [cytosol] (Homo sapiens)
        
        GSPT2 [cytosol] (Homo sapiens)
      - Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Homo sapiens)
        
        eRF3:GDP [cytosol] (Homo sapiens)
        
        eRF3 [cytosol] (Homo sapiens)
        
        GSPT2 [cytosol] (Homo sapiens)
    - p-4S-UPF1 recruits SMG5, SMG7, SMG6, PNRC2, DCP1A, and PP2A (Homo sapiens)
      - Phosphorylated UPF1:SMG5:SMG7:SMG6:PP2A:Translated mRNP [cytosol] (Homo sapiens)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Homo sapiens)
        
        eRF3:GDP [cytosol] (Homo sapiens)
        
        eRF3 [cytosol] (Homo sapiens)
        
        GSPT2 [cytosol] (Homo sapiens)
      - SMG1:Phosphorylated UPF1:EJC:Translated mRNP [cytosol] (Homo sapiens)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Homo sapiens)
        
        eRF3:GDP [cytosol] (Homo sapiens)
        
        eRF3 [cytosol] (Homo sapiens)
        
        GSPT2 [cytosol] (Homo sapiens)
  - Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) (Homo sapiens)
    - Formation of UPF1:eRF3 complex on mRNA with a premature termination codon and no Exon Junction Complex (Homo sapiens)
      - Translated mRNA Complex with Premature Termination Codon Not Preceding Exon Junction [cytosol] (Homo sapiens)
        
        eRF3:GDP [cytosol] (Homo sapiens)
        
        eRF3 [cytosol] (Homo sapiens)
        
        GSPT2 [cytosol] (Homo sapiens)
      - UPF1:eRF3 Complex on Translated mRNA [cytosol] (Homo sapiens)
        
        Translated mRNA Complex with Premature Termination Codon Not Preceding Exon Junction [cytosol] (Homo sapiens)
        
        eRF3:GDP [cytosol] (Homo sapiens)
        
        eRF3 [cytosol] (Homo sapiens)
        
        GSPT2 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q8IYD1 GSPT2

Gene Names

GSPT2, ERF3B

Chain

chain:1-628

Reference Genes

BioGPS Gene:23708 GSPT2

COSMIC (genes):GSPT2 GSPT2

CTD Gene:23708 GSPT2

dbSNP Gene:23708 GSPT2

ENSEMBL:ENSG00000189369 GSPT2

HGNC:4622 GSPT2

KEGG:hsa:23708 GSPT2

Monarch:23708 GSPT2

NCBI Gene:23708 GSPT2

OMIM:300418 GSPT2

UCSC:Q8IYD1 GSPT2

Reference Transcript

RefSeq:NM_018094.4 GSPT2

Other Identifiers

11726457_a_at

11726458_s_at

11750914_a_at

17103799

205541_PM_s_at

205541_s_at

23708

3680638

3977647

3977648

3977649

3977650

46161_at

8167654

A_14_P134529

A_14_P202104

A_23_P19115

GE55744

GO:0000184

GO:0003723

GO:0003747

GO:0003824

GO:0003924

GO:0005515

GO:0005525

GO:0005737

GO:0005829

GO:0006412

GO:0006415

GO:0016071

GO:0016787

GO:0018444

GO:0045182

HMNXSV003047863

ILMN_1730101

PH_hs_0003825

TC0X000295.hg

g8922423_3p_s_at

Participates

as a member of

eRF3 [cytosol] (Homo sapiens)

Inferred To

eRF3 [cytosol] (Drosophila melanogaster)

gspt1l [cytosol] (Danio rerio)

gspt1 [cytosol] (Danio rerio)

Homologues of GSPT2 [cytosol] (Danio rerio)

erfa-3 [cytosol] (Caenorhabditis elegans)

GSPT2 [cytosol] (Bos taurus)

GSPT2 [cytosol] (Canis familiaris)

GSPT2 [cytosol] (Dictyostelium discoideum)

GSPT2 [cytosol] (Gallus gallus)

GSPT2 [cytosol] (Mus musculus)

GSPT2 [cytosol] (Plasmodium falciparum)

GSPT2 [cytosol] (Saccharomyces cerevisiae)

GSPT2 [cytosol] (Schizosaccharomyces pombe)

GSPT2 [cytosol] (Sus scrofa)

Gspt2 [cytosol] (Rattus norvegicus)

Cross References

ENSEMBL

ENSP00000341247, ENSG00000189369, ENST00000340438

OpenTargets

ENSG00000189369

GeneCards

GSPT2

HPA

ENSG00000189369-GSPT2

PRO

Q8IYD1

Pharos - Targets

Q8IYD1

GlyGen

Q8IYD1

HMDB Protein

HMDBP08383

PDB

3KUJ

Interactors (9)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P11940 PABPC1	1	PABPC1 [cytosol] (R-HSA-156803)	0.891	10
UniProt:Q92900 UPF1	2	UPF1 [cytosol] (R-HSA-927734) p-4S-UPF1 [cytosol] (R-HSA-927856)	0.677	4
UniProt:P62495 ETF1	3	ETF1 [cytosol] (R-HSA-54433) 4OHK63-ETF1 [cytosol] (R-HSA-9629948) Me-Q185-ETF1 [cytosol] (R-HSA-6800157)	0.669	3
UniProt:O00425 IGF2BP3	1	IGF2BP3 [cytosol] (R-HSA-428313)	0.527	3
UniProt:Q09161 NCBP1	2	NCBP1 [nucleoplasm] (R-HSA-51469) NCBP1 [cytosol] (R-HSA-162459)	0.527	3
UniProt:O15234 CASC3	2	CASC3 [nucleoplasm] (R-HSA-8849148) CASC3 [cytosol] (R-HSA-927807)	0.527	3
UniProt:Q6PKG0 LARP1	1	LARP1 [cytosol] (R-HSA-9760421)	0.527	3
UniProt:O75152 ZC3H11A	1	ZC3H11A [nucleoplasm] (R-HSA-8850659)	0.527	2
UniProt:Q86VM9 ZC3H18	1	ZC3H18 [nucleoplasm] (R-HSA-9930040)	0.527	2

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