Reactome | SFN [cytosol]

SFN [cytosol]

Stable Identifier

R-HSA-1445105

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

14-3-3 sigma, 14-3-3 protein sigma, 1433S_HUMAN

Locations in the PathwayBrowser for interactor UniProt:Q6P1L5 F117B

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External Reference Information

External Reference

UniProt:P31947 SFN

Gene Names

SFN, HME1

Chain

chain:1-248

Reference Genes

BioGPS Gene:2810 SFN

COSMIC (genes):SFN SFN

CTD Gene:2810 SFN

dbSNP Gene:2810 SFN

ENSEMBL:ENSG00000175793 SFN

ENSEMBL_homo_sapiens_GENE:ENSG00000175793.12 SFN

HGNC:10773 SFN

KEGG Gene (Homo sapiens):2810 SFN

Monarch:2810 SFN

NCBI Gene:2810 SFN

OMIM:601290 SFN

UCSC:P31947 SFN

Reference Transcript

RefSeq:NM_006142.3 SFN

Other Identifiers

11717576_a_at

16661314

209260_PM_at

209260_at

2326775

2326776

2326777

2326778

2326779

2326780

2810

33322_3p_i_at

33322_PM_i_at

33322_i_at

33323_PM_r_at

33323_r_at

75288_at

7899265

A_14_P133833

A_23_P63254

A_33_P3389286

GE79528

GO:0000122

GO:0001836

GO:0002376

GO:0003334

GO:0005515

GO:0005576

GO:0005615

GO:0005634

GO:0005737

GO:0005829

GO:0006351

GO:0006355

GO:0006469

GO:0006611

GO:0006886

GO:0006913

GO:0007005

GO:0007165

GO:0008426

GO:0008630

GO:0010482

GO:0010737

GO:0010839

GO:0012501

GO:0019901

GO:0023052

GO:0030154

GO:0030216

GO:0030307

GO:0031424

GO:0036211

GO:0042802

GO:0043154

GO:0043226

GO:0043588

GO:0043616

GO:0045296

GO:0045606

GO:0045824

GO:0046827

GO:0048856

GO:0050815

GO:0051219

GO:0051726

GO:0061436

GO:0070062

GO:0072089

GO:0098542

GO:0098772

GO:0140311

GO:0140313

GO:2000647

HMNXSV003053202

ILMN_1806607

PH_hs_0029373

PH_hs_0030806

TC01000353.hg

X57348_s_at

g12653124_3p_at

g12653124_3p_x_at

Participates

as an output of

TP53 stimulates SFN expression (Homo sapiens)

as a component of

as an input of

SFN dimerizes (Homo sapiens)

Inferred To

14-3-3 sigma [cytosol] (Mus musculus)

Sfn [cytosol] (Rattus norvegicus)

14-3-3zeta [cytosol] (Drosophila melanogaster)

par-5 [cytosol] (Caenorhabditis elegans)

ywhaqb [cytosol] (Danio rerio)

ywhaq [cytosol] (Xenopus tropicalis)

14-3-3I [cytosol] (Plasmodium falciparum)

Homologues of SFN [cytosol] (Caenorhabditis elegans)

Homologues of SFN [cytosol] (Danio rerio)

SFN [cytosol] (Bos taurus)

SFN [cytosol] (Gallus gallus)

SFN [cytosol] (Sus scrofa)

ywhaqa [cytosol] (Danio rerio)

ftt-2 [cytosol] (Caenorhabditis elegans)

Cross References

RefSeq

NP_006133.1

OpenTargets

ENSG00000175793

HPA

ENSG00000175793-SFN

GeneCards

P31947

ZINC target

P31947

Ensembl

ENSP00000340989, ENSG00000175793, ENST00000339276

PRO

P31947

Pharos - Targets

P31947

PDB

8BY9, 5HF3, 7O6J, 6FI4, 7BI3, 5MY9, 4Y32, 7O6O, 7NPG, 6SIP, 6Y3W, 6QZR, 7BA9, 5OK9, 3SMK, 7BM9, 7NRK, 7OBD, 7OQS, 5N5R, 8C42, 7OBG, 6RM5, 5MHC, 8AV0, 6Y3R, 8BYO, 3SMM, 7O5D, 8ARR, 8ALR, 3IQJ, 6YOX, 6TCH, 5BTV, 8BX4, 8A6H, 6FCP, 7BFW, 7NR7, 7NZK, 7NYG, 6G8K, 8C2Y, 3P1P, 8ATS, 6HMU, 8ALW, 6SLX, 6S40, 7O5A, 6RL4, 8AR5, 7OQJ, 8ATP, 7O6K, 8C2F, 7PWT, 6RWS, 8BYF, 6Y3M, 4DHP, 8B4Q, 7OBY, 6SIQ, 7O6G, 3T0L, 7O59, 7NJ6, 6HKF, 7NIF, 8AQE, 6G8I, 6Y3S, 8AZE, 6SIN, 7BA8, 7O07, 6R5L, 7AZ2, 8C3Z, 6G8L, 7NQP, 4DHM, 7O5F, 8ALT, 6SLV, 8ARW, 7NYE, 8ARO, 1YWT, 6RKM, 5N75, 8BZW, 6S39, 6QDT, 6YOW, 3P1N, 8BX0, 8C2D, 7ORT, 8Q4L, 7BIQ, 5OMA, 7NZ6, 7O5C, 6GHP, 7NP2, 7AOG, 6FBW, 6RX2, 7OR3, 6ZVC, 8A62, 7BG3, 6YP3, 7NM3, 3U9X, 8BYE, 6T5F, 7NSV, 7O34, 8ANF, 8BI7, 6Y40, 8ALV, 8ARX, 8BJG, 8BXM, 6ZVE, 8AS1, 7BMC, 6FI5, 7O3F, 7BAB, 7BIY, 8BYG, 7B9T, 7OR7, 6RJQ, 6TLG, 7NIX, 6Y7T, 7OBK, 7NJA, 4JDD, 6RP6, 6RM7, 4IEA, 7BGQ, 8AXU, 6Y58, 5LU1, 7O3S, 8B39, 8BWZ, 6HMT, 7O5P, 8BZB, 6ZVD, 6YPL, 7NRL, 6G8Q, 6NV2, 8A65, 8A6F, 6HKB, 4DHO, 8BZ9, 8C4F, 6ZVB, 7O6M, 7O3Q, 7PWZ, 6Y3V, 8AWG, 4FR3, 8BYZ, 8AV4, 7O5O, 8BYC, 6TJM, 6TL3, 5N5W, 7O3A, 8ANB, 7NLE, 7B9M, 6S9Q, 7NIG, 8ARY, 7NJ8, 6YOY, 6YIA, 8C04, 3SMO, 7NJ9, 7BAA, 7OBH, 8BWJ, 8B2I, 7O5G, 7NZG, 8C3C, 6Y44, 6QHL, 7O3P, 7BIW, 6YE9, 7B9R, 6QIU, 4DHR, 3IQV, 7ZMU, 8AU2, 6YP2, 8AM7, 5OM0, 4Y5I, 6RHC, 7OQU, 6SLW, 3P1R, 8C2G, 7BDP, 7O5S, 6HN2, 8B5P, 6T5H, 6YPY, 1YZ5, 8AV7, 7BGR, 7NMW, 8BXS, 7NN2, 8C2E, 4QLI, 7AEW, 3T0M, 4JC3, 7NV4, 7NJB, 8BYY, 6Y8E, 8C43, 7OBS, 6TM7, 6Y8A, 7ORG, 8AV3, 7NWS, 6XXC, 6QDS, 3LW1, 7OQ8, 3SMN, 8ATR, 6Y1J, 6FBB, 7NFW, 3IQU, 7O57, 6RJL, 6RKK, 7NM9, 8AOY, 7BJF, 6XWD, 7AYF, 4FL5, 5MOC, 7NXW, 3O8I, 8BFC, 7OB8, 5LTW, 3P1Q, 7OQW, 6YP8, 7AXN, 7NVI, 7NM1, 6G8P, 7O5U, 8BM5, 7NXS, 7OPW, 8ARZ, 4Y3B, 6ZCJ, 6QHM, 8BXO, 4DAU, 8AUY, 6Y18, 8P0D, 6FAV, 6YIC, 7NZV, 3SPR, 8C40, 6Y8B, 8ANC, 8A68, 7ZMW, 6TLF, 7OR5, 8AV8, 7QIK, 8APS, 6RK8, 5OEH, 4DHQ, 8BX3, 7O3R, 8BZF, 7NMA, 6G6X, 3P1O, 8ADM, 7OBL, 8C28, 4DHT, 3SML, 6YIB, 7BJB, 6T80, 7OQ7, 6Y3O, 7ORH, 6YR7, 7B15, 3P1S, 7BA5, 8AFN, 6YR6, 7NYF, 8AQZ, 3SP5, 7NK5, 8C0K, 5MYC, 8BXN, 8BYD, 7BDY, 6QZS, 5N5T, 8B2K, 6RWU, 6SIO, 7QIP, 5OKF, 7O6I, 7OQG, 6FAW, 6S3C, 8AUS, 6RKI, 7BA7, 6YLU, 6QDR, 7NPB, 8BXQ, 7NLA, 6RWH, 8ARQ, 7OBC, 6XY5, 7BKH, 8BZC, 3UX0, 7BGW, 8BWX, 4DHU, 6RL6, 8ARG, 7NXY, 7NND, 7OBT, 8BZA, 7NMH, 7BJL, 4DHN, 8C4G, 5MXO, 8AXE, 7BJW, 7NK3, 6W0L, 7OQ9, 7ORS, 6YQ2, 8BZ0, 7BA3, 7OR8, 7NIZ, 6G8J, 6Y1D, 7O6F, 6Y8D, 7OQA, 7OB5, 6FAU, 8BYB, 8BXI, 7BDT, 8AQC, 9AXA, 7AZ1, 7BGV, 8AQ1, 6HHP, 7OBX, 6QDU, 7BA6, 3MHR, 6RWI, 8AI0, 7O5X, 8AR4, 6RJZ, 5OEG, 7B13, 4DAT, 7NMX, 4DHS, 6TWZ, 6RL3, 6YR5, 8BJN, 7NXT, 5LU2, 8C30, 6FBY, 7NNE, 8AT9, 7NY4

Interactors (140)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q92934 BAD	4	p-S99-BAD [cytosol] (R-HSA-198335) BAD [cytosol] (R-HSA-50662) BAD [mitochondrial outer membrane] (R-HSA-114242) p-S91-BAD [cytosol] (R-HSA-217297)	0.906	9
UniProt:P04049 RAF1	20	p-S338,Y340,Y341-RAF1 [cytosol] (R-HSA-5624465) p-S338-RAF1 [cytosol] (R-HSA-5624469) p-S621-RAF1 S259F [cytosol] (R-HSA-9656124) p-S621-RAF1 S257L [cytosol] (R-HSA-9656121) p-S621-RAF1 P261L [cytosol] (R-HSA-9656106) p-S621-RAF1 N262K [cytosol] (R-HSA-9656101) p-S621-RAF1 P261A [cytosol] (R-HSA-9656103) p-S621-RAF1 P261S [cytosol] (R-HSA-9656113) p-S621-RAF1 S259T [cytosol] (R-HSA-9656130) p-S621-RAF1 P261T [cytosol] (R-HSA-9656115) p-S621-RAF1 P261R [cytosol] (R-HSA-9656110) p-S621-RAF1 S259P [cytosol] (R-HSA-9656127) p-S621-RAF1 T260I [cytosol] (R-HSA-9656136) p-S621-RAF1 T260R [cytosol] (R-HSA-9656139) p-S621-RAF1 V263A [cytosol] (R-HSA-9656148) p-S621-RAF1 R256S [cytosol] (R-HSA-9656119) p-S621-RAF1 T491I [cytosol] (R-HSA-9656143) p-S621-RAF1 D486N [cytosol] (R-HSA-9656088) p-S621-RAF1 S427G [cytosol] (R-HSA-9656134) p-S621-RAF1 L613V [cytosol] (R-HSA-9656098)	0.887	9
UniProt:P00533 EGFR	20	p-6Y-EGFR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869138) p-5Y-EGFRvIII [plasma membrane] (R-HSA-1248649) EGFRvIII [plasma membrane] (R-HSA-1214162) p-6Y-EGFR E746_A750del;T790M [plasma membrane] (R-HSA-1182985) p-6Y-EGFR L858R;T790M [plasma membrane] (R-HSA-1182984) p-6Y-EGFR A767_V769dup [plasma membrane] (R-HSA-1996343) p-6Y-EGFR N771_H773dup [plasma membrane] (R-HSA-1996342) p-6Y-EGFR K739_I744dup [plasma membrane] (R-HSA-1996346) p-6Y-EGFR D770_N771insNPG [plasma membrane] (R-HSA-1996335) p-6Y-EGFR E746_A750del [plasma membrane] (R-HSA-1181214) p-6Y-EGFR L858R [plasma membrane] (R-HSA-1173211) p-6Y-EGFR G719S [plasma membrane] (R-HSA-1169417) p-6Y-EGFR L747_P753delinsS [plasma membrane] (R-HSA-1228038) p-6Y-EGFR L747_A750delinsP [plasma membrane] (R-HSA-1228044) p-6Y-EGFR L747_T751del [plasma membrane] (R-HSA-1228041) p-6Y-EGFR L747_S752del [plasma membrane] (R-HSA-1228040) p-6Y-EGFR L747_T751delinsP [plasma membrane] (R-HSA-1228042) p-6Y-EGFR E746_T751delinsA [plasma membrane] (R-HSA-1228037) p-6Y-EGFR E746_S752delinsV [plasma membrane] (R-HSA-1228039) p-6Y-EGFR L861Q [plasma membrane] (R-HSA-1177541)	0.833	9
UniProt:P63104 YWHAZ	2	YWHAZ [nucleoplasm] (R-HSA-450469) YWHAZ [cytosol] (R-HSA-206099)	0.792	8
UniProt:P56524 HDAC4	3	polySUMO2,3-K559-HDAC4 [nucleoplasm] (R-HSA-4616029) monoSUMO1-K559-HDAC4 [nucleoplasm] (R-HSA-4616016) HDAC4 [nucleoplasm] (R-HSA-351581)	0.783	8
UniProt:P10398 ARAF	4	p-S299,S302,T452,T455,S582 ARAF [cytosol] (R-HSA-5672646) p-S299,S302,T452,T455,S582 ARAF [plasma membrane] (R-HSA-5672648) p-S582 ARAF [cytosol] (R-HSA-5672681) p-S214,S582 ARAF [cytosol] (R-HSA-5672639)	0.758	4
UniProt:P31947 SFN	1	SFN [cytosol] (R-HSA-1445105)	0.756	5
UniProt:P04637 TP53	20	Unfolded TP53 [cytosol] (R-HSA-6813797) TP53 [cytosol] (R-HSA-8869337) PolyUb-TP53 [nucleoplasm] (R-HSA-6782509) polySUMO2,3-K386-TP53 [nucleoplasm] (R-HSA-2997661) TP53 F341C [nucleoplasm] (R-HSA-9726318) TP53 G334V [nucleoplasm] (R-HSA-9726126) TP53 L330H [nucleoplasm] (R-HSA-9726124) TP53 A347T [nucleoplasm] (R-HSA-9726339) TP53 R337C [nucleoplasm] (R-HSA-9726118) TP53 L344P [nucleoplasm] (R-HSA-9726075) TP53 L344R [nucleoplasm] (R-HSA-9726073) TP53 R337H [nucleoplasm] (R-HSA-9726169) TP53 R337P [nucleoplasm] (R-HSA-9726168) TP53 L330P [nucleoplasm] (R-HSA-9726136) TP53 L348S [nucleoplasm] (R-HSA-9726366) TP53 R337L [nucleoplasm] (R-HSA-9726163) TP53 K351E [nucleoplasm] (R-HSA-9726258) TP53 F338I [nucleoplasm] (R-HSA-9726358) TP53 R342P [nucleoplasm] (R-HSA-9726101) TP53 L330R [nucleoplasm] (R-HSA-9726133)	0.738	5
UniProt:P27448 MARK3	1	MARK3 [cytosol] (R-HSA-5672591)	0.72	5
UniProt:Q8NHY2 RFWD2	3	p-S387-RFWD2 [nucleoplasm] (R-HSA-349450) RFWD2 [nucleoplasm] (R-HSA-349454) p-S387-RFWD2 [cytosol] (R-HSA-349439)	0.718	6
UniProt:Q5S007 LRRK2	1	LRRK2 [cytosol] (R-HSA-5661173)	0.713	5
UniProt:P15056 BRAF	20	BRAF(1-380)-MACF1(600-7388)fusion [cytosol] (R-HSA-6802402) p-BRAF(1-380)-MACF1(600-7388) fusion [cytosol] (R-HSA-6802536) BRAF E501G [cytosol] (R-HSA-9651132) BRAF D594N [cytosol] (R-HSA-6802299) BRAF D638E [cytosol] (R-HSA-9651125) BRAF G596R [cytosol] (R-HSA-6802385) BRAF D594V [cytosol] (R-HSA-6802305) BRAF G596V [cytosol] (R-HSA-9651138) BRAF G466E [cytosol] (R-HSA-6802374) BRAF D594G [cytosol] (R-HSA-6802295) BRAF L505H [cytosol] (R-HSA-9648845) BRAF F595L [cytosol] (R-HSA-6802316) BRAF L597V [cytosol] (R-HSA-6802397) BRAF G464E [cytosol] (R-HSA-6802369) BRAF N581D [cytosol] (R-HSA-9651152) BRAF E586K [cytosol] (R-HSA-6802308) BRAF V600K [cytosol] (R-HSA-6802502) BRAF A246P [cytosol] (R-HSA-9651123) BRAF G469V [cytosol] (R-HSA-9648620) BRAF T244P [cytosol] (R-HSA-9651165)	0.713	5
UniProt:Q8WUI4 HDAC7	1	HDAC7 [nucleoplasm] (R-HSA-3004534)	0.688	3
UniProt:Q6ICG6 K0930			0.688	3
UniProt:P30305 CDC25B	3	p-S50,T69,S160,S321,S470-CDC25B [cytosol] (R-HSA-8863644) CDC25B [cytosol] (R-HSA-157412) CDC25B [nucleoplasm] (R-HSA-69734)	0.688	3
UniProt:Q9Y2U5 M3K2			0.688	3
UniProt:Q13470 TNK1			0.688	3
UniProt:P98177 FOXO4	8	FOXO4 [nucleoplasm] (R-HSA-5690183) p-T32,S197,S262-FOXO4 [nucleoplasm] (R-HSA-199314) p-T32,S197,S262-FOXO4 [cytosol] (R-HSA-9614415) SOH-C481-FOXO4 [nucleoplasm] (R-HSA-9617655) CREBBP-S-S-FOXO4 [nucleoplasm] (R-HSA-9617679) EP300-S-S-FOXO4 [nucleoplasm] (R-HSA-9617681) Ac-K-FOXO4 [nucleoplasm] (R-HSA-9617761) PolyUb-FOXO4 [nucleoplasm] (R-HSA-6782501)	0.675	4
UniProt:P61981 YWHAG	1	YWHAG [cytosol] (R-HSA-380312)	0.669	4
UniProt:P30291 WEE1	3	p-WEE1 [nucleoplasm] (R-HSA-156491) p-S53-WEE1 [nucleoplasm] (R-HSA-156694) WEE1 [nucleoplasm] (R-HSA-69253)	0.667	5
UniProt:P00519 ABL1	6	p-Y393-ABL1 [cytosol] (R-HSA-9865161) p-Y226,Y393-ABL1 [nucleoplasm] (R-HSA-8985251) ABL1 [cytosol] (R-HSA-375987) p-Y226,Y393-ABL1 [cytosol] (R-HSA-8942610) ABL1 [nucleoplasm] (R-HSA-5686579) p-S456-ABL1 [nucleoplasm] (R-HSA-5686576)	0.667	5
UniProt:Q96HA8 NTAQ1			0.666	4
UniProt:P51946 CCNH	1	CCNH [nucleoplasm] (R-HSA-69220)	0.666	4
UniProt:Q7L5N1 COPS6	2	COPS6 [nucleoplasm] (R-HSA-5697026) COPS6 [cytosol] (R-HSA-416961)	0.653	7
UniProt:O00444 PLK4	1	PLK4 [cytosol] (R-HSA-380286)	0.646	3
UniProt:Q9H2C0 GAN	1	GAN [cytosol] (R-HSA-976014)	0.641	3
UniProt:Q99959 PKP2	2	PKP2 [cornified envelope] (R-HSA-8847734) PKP2 [plasma membrane] (R-HSA-6814393)	0.628	5
UniProt:O96013 PAK4	1	PAK4 [cytosol] (R-HSA-428461)	0.628	5
UniProt:O75494 SRSF10	1	SRSF10 [nucleoplasm] (R-HSA-8866646)	0.628	3
UniProt:Q9UPU9 SMAG1			0.628	4
UniProt:P40818 USP8	2	USP8 [cytosol] (R-HSA-917720) p-T945-USP8 [cytosol] (R-HSA-1358714)	0.628	5
UniProt:O14639 ABLIM1	1	ABLIM1 [cytosol] (R-HSA-416771)	0.628	5
UniProt:Q5VV41 ARHGEF16	1	ARHGEF16 [cytosol] (R-HSA-2976623)	0.628	5
UniProt:Q9H0B6 KLC2	1	KLC2 [cytosol] (R-HSA-983191)	0.628	5
UniProt:Q86W92 PPFIBP1	5	PPFIBP1 [cytosol] (R-HSA-6799300) PPFIBP1(1-349)insK-ALK(1058-1620) fusion [cytosol] (R-HSA-9711955) PPFIBP1(1-232)-ALK(1058-1620) fusion [cytosol] (R-HSA-9711976) PPFIBP1(1-232)-p-7Y-ALK(1058-1620) fusion [cytosol] (R-HSA-9711963) PPFIBP1(1-349)insK-p-7Y-ALK(1058-1620) fusion [cytosol] (R-HSA-9711961)	0.628	4
UniProt:Q5T1R4 HIVEP3	1	HIVEP3 [cytosol] (R-HSA-9008029)	0.618	5
UniProt:Q04917 YWHAH	1	YWHAH [cytosol] (R-HSA-1445107)	0.615	6
UniProt:Q9UQC2 GAB2	5	p-Y643-GAB2 [cytosol] (R-HSA-9677149) p-5Y-GAB2 [cytosol] (R-HSA-8855574) p-Y-GAB2 [cytosol] (R-HSA-912529) p-Y452,Y476,Y584-GAB2 [cytosol] (R-HSA-2685615) GAB2 [cytosol] (R-HSA-508239)	0.615	6
UniProt:P62258 YWHAE	1	YWHAE [cytosol] (R-HSA-194368)	0.604	5
UniProt:Q14103-4 HNRNPD	2	Ub-HNRNPD-4 [cytosol] (R-HSA-451232) HNRNPD-4 [cytosol] (R-HSA-450442)	0.602	7
UniProt:P35568 IRS1	5	p-Y-IRS1 [plasma membrane] (R-HSA-198366) p-Y-IRS1 [cytosol] (R-HSA-74772) IRS1 [cytosol] (R-HSA-74769) IRS1 [plasma membrane] (R-HSA-2425392) p-6Y-IRS1 [plasma membrane] (R-HSA-2445090)	0.589	2
UniProt:O15151 MDM4	5	PolyUb-MDM4 [nucleoplasm] (R-HSA-6782502) p-S403-MDM4 [nucleoplasm] (R-HSA-349461) p-S346,S367,S403-MDM4 [nucleoplasm] (R-HSA-349441) PolyUb,p-S342,S367,S403-MDM4 [nucleoplasm] (R-HSA-6804938) MDM4 [nucleoplasm] (R-HSA-349430)	0.589	2
UniProt:Q86X27 RGPS2			0.589	2
UniProt:Q86YV5 SGK223	1	PRAG1 [cytosol] (R-HSA-9696532)	0.589	2
UniProt:Q9H1K1 ISCU	1	ISCU [cytosol] (R-HSA-9771680)	0.589	2
UniProt:O60269 GRIN2			0.573	2
UniProt:P49815 TSC2	4	p-S939,S1130,T1462-TSC2 [cytosol] (R-HSA-165164) p-S939,T1462-TSC2 [cytosol] (R-HSA-199484) TSC2 [cytosol] (R-HSA-2980548) p-S1387-TSC2 [cytosol] (R-HSA-3132769)	0.571	3
UniProt:Q6NUK4 REEP3			0.564	2
UniProt:Q14153 FA53B			0.564	2
UniProt:O95382 M3K6			0.564	2
UniProt:Q9H093 NUAK2			0.564	2
UniProt:Q02156 PRKCE	2	PRKCE [cytosol] (R-HSA-58202) p-T566,T710,S729-PRKCE [plasma membrane] (R-HSA-198260)	0.564	2
UniProt:Q13322 GRB10	2	p-Y GRB10 [cytosol] (R-HSA-9706168) GRB10 [cytosol] (R-HSA-110009)	0.564	2
UniProt:P22681 CBL	20	PolyUb,p-Y-CBL [cytosol] (R-HSA-9763893) CBL R420G [cytosol] (R-HSA-9706203) CBL R420Q [cytosol] (R-HSA-9706186) CBL Y371H [cytosol] (R-HSA-9706680) CBL H398Y [cytosol] (R-HSA-9706639) CBL P417A [cytosol] (R-HSA-9706636) CBL S376F [cytosol] (R-HSA-9706643) CBL E366_Q409del [cytosol] (R-HSA-9706179) CBL del366-477 [cytosol] (R-HSA-9706176) CBL R499L [cytosol] (R-HSA-9706678) CBL L380P [cytosol] (R-HSA-9706630) CBL L287R [cytosol] (R-HSA-9706693) CBL L380R [cytosol] (R-HSA-9706635) CBL G375P [cytosol] (R-HSA-9706219) CBL P417L [cytosol] (R-HSA-9706634) CBL H398Q [cytosol] (R-HSA-9706633) CBL P417R [cytosol] (R-HSA-9706632) CBL R499* [cytosol] (R-HSA-9706670) CBL H398R [cytosol] (R-HSA-9706638) CBL H398P [cytosol] (R-HSA-9706637)	0.564	2
UniProt:Q16288 NTRK3	6	NTRK3(32-495) [plasma membrane] (R-HSA-9603541) NTRK3(642-839) [cytosol] (R-HSA-9603540) NTRK3(496-641) [mitochondrial outer membrane] (R-HSA-9603557) NTRK3(496-641) [cytosol] (R-HSA-9603542) NTRK3 [plasma membrane] (R-HSA-6798240) p-5Y-NTRK3 [plasma membrane] (R-HSA-9034718)	0.564	2
UniProt:Q08881 ITK	3	p-Y180,Y512-ITK [cytosol] (R-HSA-2685616) p-Y512-ITK [cytosol] (R-HSA-422519) ITK [cytosol] (R-HSA-202319)	0.564	2
UniProt:P10636-2 MAPT			0.558	2
UniProt:Q86Z20 CC125			0.556	3
UniProt:Q9NYF3 FA53C			0.556	3
UniProt:Q17RB8 LONRF1	1	LONRF1 [cytosol] (R-HSA-8850905)	0.556	3
UniProt:Q8IZU0 FAM9B			0.556	3
UniProt:Q68D86 C102B			0.556	3
UniProt:P43355 MAGA1			0.556	3
UniProt:Q9UJM3 ERRFI			0.556	3
UniProt:Q13064 MKRN3			0.556	3
UniProt:Q53FD0 ZC21C			0.556	3
UniProt:P55771 PAX9			0.556	3
UniProt:Q03373 DIG2			0.556	3
UniProt:Q96QF0 RAB3IP	1	RAB3IP [cytosol] (R-HSA-5617610)	0.556	3
UniProt:Q9UQL6 HDAC5	1	HDAC5 [nucleoplasm] (R-HSA-3004533)	0.547	3
UniProt:Q8NFH8 REPS2	1	REPS2 [cytosol] (R-HSA-432938)	0.544	2
UniProt:Q6R327 RICTOR	1	RICTOR [cytosol] (R-HSA-198632)	0.536	4
UniProt:Q5T5U3 ARHGAP21	1	ARHGAP21 [cytosol] (R-HSA-8873918)	0.536	4
UniProt:Q96F86 EDC3	1	EDC3 [cytosol] (R-HSA-429997)	0.536	4
UniProt:O94885 SASH1			0.536	4
UniProt:Q9P2M7 CGN	1	CGN [cell junction] (R-HSA-2134478)	0.536	4
UniProt:P56945 BCAR1	4	p-Y-BCAR1 [cytosol] (R-HSA-372645) p-Y12-BCAR1 [cytosol] (R-HSA-5218739) p-Y165,Y664-BCAR1 [cytosol] (R-HSA-8848723) BCAR1 [cytosol] (R-HSA-201625)	0.536	2
UniProt:Q6P1L5 F117B			0.536	4
UniProt:O94875 SRBS2			0.536	4
UniProt:Q92625 ANS1A			0.536	4
UniProt:P78524 ST5	1	ST5 [cytosol] (R-HSA-8876091)	0.536	2
UniProt:Q8TF72 SHRM3			0.536	2
UniProt:Q9NYL2 M3K20			0.536	4
UniProt:Q8TEW8 PAR3L			0.536	2
UniProt:O15056 SYNJ2	1	SYNJ2 [cytosol] (R-HSA-1806193)	0.536	2
UniProt:Q9H6H4 REEP4			0.536	4
UniProt:Q8TEW0 PARD3	3	PARD3 [plasma membrane] (R-HSA-419980) PARD3 [cytosol] (R-HSA-419993) PARD3 [cell junction] (R-HSA-2134481)	0.536	4
UniProt:A7KAX9 ARHGAP32	1	ARHGAP32 [cytosol] (R-HSA-195134)	0.536	3
UniProt:Q12774 ARHGEF5	1	ARHGEF5 [cytosol] (R-HSA-8873909)	0.536	4
UniProt:O75592 MYCB2			0.536	4
UniProt:O00750 PIK3C2B	1	PIK3C2B [cytosol] (R-HSA-1604619)	0.536	4
UniProt:O60292 SI1L3			0.536	4
UniProt:P33176 KIF5B	3	KIF5B [cytosol] (R-HSA-265181) KIF5B(2-575)-p-7Y-ALK(1063-1620) fusion [cytosol] (R-HSA-9711937) KIF5B(2-575)-ALK(1063-1620) fusion [cytosol] (R-HSA-9711964)	0.536	2
UniProt:Q6WCQ1 MPRIP	2	MPRIP(2-1015)-RAF1(279-648) fusion [cytosol] (R-HSA-6802406) MPRIP(2-1015)-p-RAF1(279-648) fusion [cytosol] (R-HSA-6802540)	0.536	3
UniProt:P25054 APC	20	APC R213* [cytosol] (R-HSA-9666924) APC C1410* [cytosol] (R-HSA-9666925) APC K1310* [cytosol] (R-HSA-9666926) APC R499* [cytosol] (R-HSA-9666927) APC R1450* [cytosol] (R-HSA-5251499) APC G1357* [cytosol] (R-HSA-9666940) APC L1488* [cytosol] (R-HSA-9666941) APC S1400* [cytosol] (R-HSA-9666942) APC S1346* [cytosol] (R-HSA-9666943) APC R405* [cytosol] (R-HSA-9666936) APC S1281* [cytosol] (R-HSA-9666937) APC E1573* [cytosol] (R-HSA-9666938) APC R805* [cytosol] (R-HSA-9666939) APC R1386* [cytosol] (R-HSA-9666932) APC S1327* [cytosol] (R-HSA-9666933) APC E1209* [cytosol] (R-HSA-9666934) APC Q1469* [cytosol] (R-HSA-9666935) APC R564* [cytosol] (R-HSA-9666928) APC E1536* [cytosol] (R-HSA-9666929) APC G1288* [cytosol] (R-HSA-9666930)	0.536	2
UniProt:Q9Y4H2 IRS2	4	IRS2 [plasma membrane] (R-HSA-2428927) IRS2 [cytosol] (R-HSA-57528) p-Y-IRS2 [cytosol] (R-HSA-74774) p-Y-IRS2 [plasma membrane] (R-HSA-198334)	0.536	4
UniProt:Q9P0V3 SH3BP4	1	SH3BP4 [cytosol] (R-HSA-8866227)	0.536	2
UniProt:Q02241 KIF23	3	KIF23 [nucleoplasm] (R-HSA-156709) p-S911,S912-KIF23 [nucleoplasm] (R-HSA-156695) KIF23 [cytosol] (R-HSA-1015863)	0.536	4
UniProt:O43166 SIPA1L1	1	SPAR [cytosol] (R-HSA-6794278)	0.536	3
UniProt:P13569 CFTR	17	PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) CFTR [lysosomal membrane] (R-HSA-5627279) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [endosome membrane] (R-HSA-6782965) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) ub-CFTR F508del [cytosol] (R-HSA-8866838) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) CFTR G542* [plasma membrane] (R-HSA-5678986) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR [plasma membrane] (R-HSA-383188) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730)	0.527	15
UniProt:P27348 YWHAQ	1	YWHAQ [cytosol] (R-HSA-1445116)	0.527	2
UniProt:Q96IF1 AJUBA	3	AJUBA [cytosol] (R-HSA-2564698) p-S-AJUBA [cytosol] (R-HSA-2574841) AJUBA [nucleoplasm] (R-HSA-5687935)	0.524	2
UniProt:Q16352 AINX			0.499	2
UniProt:Q7Z6J0 SH3RF1	1	SH3RF1 [cytosol] (R-HSA-5688968)	0.499	2
UniProt:P25685 DNAJB1	3	p-S149,S151,S171 DNAJB1 [cytosol] (R-HSA-5690241) DNAJB1 [cytosol] (R-HSA-3299666) DNAJB1 [nucleoplasm] (R-HSA-5082366)	0.499	2
UniProt:Q86X02 CDR2L			0.483	4
UniProt:P85299 PRR5	1	PRR5 [cytosol] (R-HSA-6795323)	0.483	3
UniProt:P31946 YWHAB	1	YWHAB [cytosol] (R-HSA-48888)	0.483	4
UniProt:Q08495 DMTN	1	DMTN [cytosol] (R-HSA-5216222)	0.483	3
UniProt:P10636 MAPT	3	MAPT(422-758) [cytosol] (R-HSA-350642) MAPT(2-421) [cytosol] (R-HSA-350628) MAPT [cytosol] (R-HSA-201574)	0.483	2
UniProt:Q9UQB8 BAIAP2	1	BAIAP2 [cytosol] (R-HSA-442574)	0.471	4
UniProt:Q9NSK0 KLC4	1	KLC4 [cytosol] (R-HSA-983244)	0.471	4
UniProt:Q8IVT5 KSR1	5	p-S311,S406 KSR1 [cytosol] (R-HSA-5672654) KSR1 [cytosol] (R-HSA-5672587) p-S311 KSR1 [cytosol] (R-HSA-5672652) p-S311,Y602 KSR1 [plasma membrane] (R-HSA-5672659) p-S311,Y602 KSR1 [cytosol] (R-HSA-5672656)	0.471	2
UniProt:Q6PKG0 LARP1	1	LARP1 [cytosol] (R-HSA-9760421)	0.471	4
UniProt:O60343 TBC1D4	2	p-5S,T642-TBC1D4 [cytoplasmic vesicle membrane] (R-HSA-1445101) TBC1D4 [cytoplasmic vesicle membrane] (R-HSA-1445122)	0.471	4
UniProt:Q86V48 LUZP1			0.471	4
UniProt:Q6IQ23 PKHA7			0.471	4
UniProt:O43524 FOXO3	11	p-S215 FOXO3 [nucleoplasm] (R-HSA-5687010) p-S215 FOXO3 [cytosol] (R-HSA-5687014) FOXO3 [cytosol] (R-HSA-5687032) p-S43,S173,S294,S325-FOXO3 [nucleoplasm] (R-HSA-8870627) p-S43,S173,S294,S325-FOXO3 [cytosol] (R-HSA-8870560) FOXO3(?-673) [mitochondrial matrix] (R-HSA-9841824) Ac-K271,K290-FOXO3(?-673) [mitochondrial matrix] (R-HSA-9841849) Ac-K242,K259,K271,K290,K569-FOXO3 [nucleoplasm] (R-HSA-9620514) p-T32,S253,S315-FOXO3 [cytosol] (R-HSA-9614413) p-T32,S253,S315-FOXO3 [nucleoplasm] (R-HSA-199289) FOXO3 [nucleoplasm] (R-HSA-199305)	0.471	3
UniProt:Q9Y3R0 GRIP1	2	GRIP1 [cytosol] (R-HSA-416633) GRIP1 [plasma membrane] (R-HSA-416638)	0.471	2
UniProt:Q8N8E3 CE112			0.471	2
UniProt:Q96S53 TESK2			0.471	2
UniProt:O43379 WDR62			0.471	4
UniProt:O14654 IRS4	2	p-Y-IRS4 [plasma membrane] (R-HSA-2424302) IRS4 [plasma membrane] (R-HSA-2424297)	0.471	4
UniProt:O43491 EPB41L2	1	EPB41L2 [cytosol] (R-HSA-6797548)	0.471	3
UniProt:Q15750 TAB1	6	TAB1(445-504) [cytosol] (R-HSA-9729691) TAB1(133-504) [cytosol] (R-HSA-9729724) TAB1(1-132) [cytosol] (R-HSA-9729698) TAB1(1-444) [cytosol] (R-HSA-9729751) TAB1 [endosome membrane] (R-HSA-450238) TAB1 [cytosol] (R-HSA-167923)	0.471	2
UniProt:Q7Z460 CLASP1	1	CLASP1 [cytosol] (R-HSA-376230)	0.471	3
UniProt:P46937 YAP1	8	p-Y407-YAP1 [cytosol] (R-HSA-9865208) p-S127-YAP1 [cytosol] (R-HSA-2028553) p-5S-YAP1 [cytosol] (R-HSA-2028554) p-Y407-YAP1 [nucleoplasm] (R-HSA-8956661) p-Y-YAP1 [cytosol] (R-HSA-8937843) p-Y-YAP1 [nucleoplasm] (R-HSA-8937857) YAP1 [cytosol] (R-HSA-1253345) YAP1 [nucleoplasm] (R-HSA-1253322)	0.471	2
UniProt:Q92974 ARHGEF2	1	ARHGEF2 [cytosol] (R-HSA-195101)	0.471	4
UniProt:Q8NEY1 NAV1			0.471	4
UniProt:O95819 MAP4K4	1	MAP4K4 [cytosol] (R-HSA-3214893)	0.471	2
UniProt:Q6P0Q8 MAST2			0.471	2
UniProt:Q8N4C8 MINK1	1	MINK1 [cytosol] (R-HSA-2532788)	0.471	3
UniProt:O60333 KIF1B	1	KIF1B [cytosol] (R-HSA-8849378)	0.471	4
UniProt:Q9H4A3 WNK1	1	WNK1 [cytosol] (R-HSA-2672391)	0.471	4
UniProt:O75122 CLASP2	1	CLASP2 [cytosol] (R-HSA-376252)	0.471	4
UniProt:Q14671 PUM1	1	PUM1 [cytosol] (R-HSA-434211)	0.471	4
UniProt:P47974 ZFP36L2	1	ZFP36L2 [cytosol] (R-HSA-9819194)	0.471	4
UniProt:Q96PU5 NEDD4L	2	NEDD4L [cytosol] (R-HSA-976003) NEDD4L [nucleoplasm] (R-HSA-2176420)	0.471	2
UniProt:Q51451 Q51451			0.469	2
UniProt:P06493 CDK1	11	CDK1 [endoplasmic reticulum membrane] (R-HSA-264424) p-Y4-CDK1 [cytosol] (R-HSA-9836187) p-T14,T161-CDK1 [nucleoplasm] (R-HSA-170078) p-T14-CDK1 [nucleoplasm] (R-HSA-170045) p-T14-CDK1 [cytosol] (R-HSA-170064) CDK1 [nucleoplasm] (R-HSA-68889) CDK1 [cytosol] (R-HSA-170075) p-T14,Y15,T161-CDK1 [cytosol] (R-HSA-170071) p-T161-CDK1 [cytosol] (R-HSA-157415) p-T14,Y15,T161-CDK1 [nucleoplasm] (R-HSA-170074) p-T161-CDK1 [nucleoplasm] (R-HSA-170066)	0.463	2

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