Reactome | p-S237-TBC1D1 [cytosol]

p-S237-TBC1D1 [cytosol]

Stable Identifier

R-HSA-1454673

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

TBC1D1 (pSer237), TBC1 domain family member 1, TBCD1_HUMAN, TBC1D1

Locations in the PathwayBrowser

Expand all

General

As inferred from rat L6 muscle cells, TBC1D1 is located in the perinuclear cytosol (Chen et al. 2008). TBC1D1 is observed throughout the cytosol and, based on its homology to TBC1D4 and its interaction with membrane-bound RAB proteins, TBC1D1 is expected to be concentrated near vesicle membranes.

Literature References

PubMed ID	Title	Journal	Year
20701589	Contraction regulates site-specific phosphorylation of TBC1D1 in skeletal muscle Vichaiwong, K, Purohit, S, An, D, Toyoda, T, Jessen, N, Hirshman, MF, Goodyear, LJ	Biochem J	2010
17995453	Complementary regulation of TBC1D1 and AS160 by growth factors, insulin and AMPK activators Chen, S, Murphy, J, Toth, R, Campbell, DG, Morrice, NA, Mackintosh, C	Biochem J	2008

External Reference Information

External Reference

UniProt:Q86TI0 TBC1D1

Gene Names

TBC1D1, KIAA1108

Chain

chain:1-1168

Reference Genes

BioGPS Gene:23216 TBC1D1

COSMIC (genes):TBC1D1 TBC1D1

CTD Gene:23216 TBC1D1

dbSNP Gene:23216 TBC1D1

ENSEMBL:ENSG00000065882 TBC1D1

HGNC:11578 TBC1D1

KEGG:hsa:23216 TBC1D1

Monarch:23216 TBC1D1

NCBI Gene:23216 TBC1D1

OMIM:609850 TBC1D1

UCSC:Q86TI0 TBC1D1

Reference Transcript

Other Identifiers

11720224_a_at

11720225_a_at

11720226_s_at

11747994_a_at

11747995_x_at

11752285_a_at

1568713_3p_a_at

1568713_PM_a_at

1568713_a_at

1569566_PM_at

1569566_at

16965942

212350_PM_at

212350_at

227945_PM_at

227945_at

23216

2723757

2723758

2723759

2723760

2723769

2723770

2723771

2723781

2723782

2723783

2723786

2723787

2723807

2723808

2723809

2723813

2723814

2723815

2723816

2723817

2723818

2723823

2723824

2723827

2723831

2723832

2723833

2723834

2723835

2723837

2723839

2723840

2723841

2723843

2723860

2723861

2723862

2723869

2723872

2723877

2723878

2723879

2723885

2723886

2723887

2723889

2723890

2723891

2723892

2723893

2723897

2723909

2723910

2723911

2723912

2723913

2723920

2723921

2723922

2723923

32506_at

44004_at

79917_at

8094574

A_14_P125996

A_14_P132551

A_14_P201721

A_23_P73023

A_24_P943613

A_33_P3370812

GE62774

GE724604

GO:0005096

GO:0005515

GO:0005634

GO:0005737

GO:0005794

GO:0032880

GO:0061179

GO:0098772

HMNXSV003041411

HMNXSV003052187

Hs.27356.0.A1_3p_at

Hs.278586.1.A1_3p_at

Hs2.203722.1.A1_3p_a_at

Hs2.203722.1.A1_3p_s_at

Hs2.203722.1.A1_3p_x_at

Hs2.203722.2.A1_3p_at

ILMN_1754947

PH_hs_0011966

PH_hs_0024215

PH_hs_0032943

TC04000214.hg

Participates

as a component of

as an output of

AMPK-alpha2 phosphorylates TBC1D1 (Homo sapiens)

as an input of

14-3-3 Binds p-S237-TBC1D1 (Homo sapiens)

Other forms of this molecule

TBC1D1 [cytoplasmic vesicle membrane]

Modified Residues

Name

O-phospho-L-serine at 237

Coordinate

237

PsiMod Name

O-phospho-L-serine [MOD:00046]

PsiMod Definition

A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.

Cross References

RefSeq

NP_055988.2, XP_054205378.1, XP_047305846.1, NP_001240841.1

OpenTargets

ENSG00000065882

ENSEMBL

ENSP00000261439, ENSP00000423651, ENSG00000065882, ENST00000508802, ENST00000261439

GeneCards

TBC1D1

HPA

ENSG00000065882-TBC1D1

PRO

Q86TI0

Pharos - Targets

Q86TI0

PDB

3QYE

Interactors (33)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P61981 YWHAG	1	YWHAG [cytosol] (R-HSA-380312)	0.816	7
UniProt:Q04917 YWHAH	1	YWHAH [cytosol] (R-HSA-1445107)	0.802	7
UniProt:P31946 YWHAB	1	YWHAB [cytosol] (R-HSA-48888)	0.802	7
UniProt:P27348 YWHAQ	1	YWHAQ [cytosol] (R-HSA-1445116)	0.745	7
UniProt:P63104 YWHAZ	2	YWHAZ [cytosol] (R-HSA-206099) YWHAZ [nucleoplasm] (R-HSA-450469)	0.745	5
UniProt:P02585 TNNC2	1	TNNC2 [cytosol] (R-HSA-390531)	0.666	4
UniProt:Q8NEU8 DP13B			0.576	4
UniProt:P62258 YWHAE	1	YWHAE [cytosol] (R-HSA-194368)	0.569	4
UniProt:Q6P2D0 ZFP1	1	ZFP1 [nucleoplasm] (R-HSA-974997)	0.556	3
UniProt:Q96EZ8 MCRS1	1	MCRS1 [nucleoplasm] (R-HSA-3321849)	0.556	3
UniProt:Q5JST6 EFHC2			0.556	3
UniProt:Q96T60 PNKP	1	PNKP [nucleoplasm] (R-HSA-5649651)	0.556	3
UniProt:Q3SY00 T10IP			0.556	3
UniProt:O95678 KRT75	1	KRT75 [cytosol] (R-HSA-6809652)	0.556	3
UniProt:Q8TBB1 LNX1	1	LNX1 [cytosol] (R-HSA-8851641)	0.556	3
UniProt:P40222 TXLNA	1	TXLNA [cytosol] (R-HSA-449124)	0.556	3
UniProt:Q96IK5 GMCL1			0.556	3
UniProt:P31273 HOXC8	1	HOXC8 [nucleoplasm] (R-HSA-3222311)	0.556	3
UniProt:Q8N715 CC185			0.556	3
UniProt:Q9Y247 FA50B			0.556	3
UniProt:Q13671 RIN1	1	RIN1 [cytosol] (R-HSA-8875287)	0.556	3
IntAct:EBI-16882364 CALM1			0.556	3
UniProt:Q96C24 SYTL4	2	SYTL4 [platelet alpha granule membrane] (R-HSA-8862959) SYTL4 [plasma membrane] (R-HSA-8862971)	0.556	3
UniProt:Q68G74 LHX8			0.556	3
UniProt:Q8N1B4 VPS52	1	VPS52 [trans-Golgi network membrane] (R-HSA-6811029)	0.556	3
UniProt:Q15560 TCEA2			0.556	3
UniProt:Q2TBE0 CWF19L2	1	CWF19L2 [nucleoplasm] (R-HSA-9770846)	0.556	3
UniProt:Q3B820 F161A			0.556	3
UniProt:Q9Y250 LZTS1			0.556	3
UniProt:Q96JM7-2 L3MBTL3			0.556	3
UniProt:O75031 HSF2B			0.556	3
UniProt:Q8IZU0 FAM9B			0.527	2
UniProt:O60293 ZFC3H1	1	ZFC3H1 [nucleoplasm] (R-HSA-9930046)	0.527	2