AMPK-alpha2 phosphorylates TBC1D1

Stable Identifier
R-HSA-1454699
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol, cytoplasmic vesicle membrane
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
AMPK-alpha2 phosphorylates TBC1D1
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
In response to muscle contraction and insulin signaling, AMPK-alpha2 phosphorylates TBC1D1 on serine 237 and probably other residues (Frosig et al. 2010, Vichaiwong et al. 2010). As inferred from rat L6 muscle cells TBC1D1 colocalizes with perinuclear vesicles bearing GLUT4 (SLC2A4) and may be involved in an early step that mobilizes them (Chen et al. 2008). Human TBC1D1 appears cytosolic and is believed to be concentrated near vesicle membranes (Park et al. 2011).
Literature References
PubMed ID Title Journal Year
17995453 Complementary regulation of TBC1D1 and AS160 by growth factors, insulin and AMPK activators

Chen, S, Murphy, J, Toth, R, Campbell, DG, Morrice, NA, Mackintosh, C

Biochem J 2008
20701589 Contraction regulates site-specific phosphorylation of TBC1D1 in skeletal muscle

Vichaiwong, K, Purohit, S, An, D, Toyoda, T, Jessen, N, Hirshman, MF, Goodyear, LJ

Biochem J 2010
21454505 Crystal structures of human TBC1D1 and TBC1D4 (AS160) RabGTPase-activating protein (RabGAP) domains reveal critical elements for GLUT4 translocation

Park, SY, Jin, W, Woo, JR, Shoelson, SE

J. Biol. Chem. 2011
20837646 Exercise-induced TBC1D1 Ser237 phosphorylation and 14-3-3 protein binding capacity in human skeletal muscle

Frøsig, C, Pehmøller, C, Birk, JB, Richter, EA, Wojtaszewski, JF

J Physiol 2010
Participants
Input
Output
Participates
as an event of
Catalyst Activity

protein serine/threonine kinase activity of AMPK-alpha2:AMPK-beta:AMPK-gamma:AMP [cytosol]

Physical Entity
AMPK-alpha2:AMPK-beta:AMPK-gamma:AMP [cytosol] (Homo sapiens)
Activity
protein serine/threonine kinase activity (GO:0004674)
Inferred From
Ampk-alpha2 Phosphorylates Tbc1d1 (Mus musculus)
Authored
May, B  (2011-07-15)
Reviewed
Klip, A  (2012-08-21)
Created
May, B  (2011-07-17)
Cite Us!