TBC1D1 [cytoplasmic vesicle membrane]

Stable Identifier
R-HSA-1454718
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytoplasmic vesicle membrane
Synonyms
TBC1 domain family member 1, TBCD1_HUMAN
Locations in the PathwayBrowser for interactor UniProt:O60293 ZC3H1
Expand all
General
As inferred from rat L6 muscle cells, TBC1D1 is located in the perinuclear cytosol (Chen et al. 2008). TBC1D1 is observed throughout the cytosol and, based on its homology to TBC1D4 and its interaction with membrane-bound RAB proteins, TBC1D1 is expected to be concentrated near vesicle membranes.
Literature References
PubMed ID Title Journal Year
17995453 Complementary regulation of TBC1D1 and AS160 by growth factors, insulin and AMPK activators

Campbell, DG, Murphy, J, Toth, R, Chen, S, Morrice, NA, Mackintosh, C

Biochem J 2008
21454505 Crystal structures of human TBC1D1 and TBC1D4 (AS160) RabGTPase-activating protein (RabGAP) domains reveal critical elements for GLUT4 translocation

Shoelson, SE, Jin, W, Park, SY, Woo, JR

J. Biol. Chem. 2011
External Reference Information
External Reference
UniProt:Q86TI0 TBC1D1
Gene Names
TBC1D1, KIAA1108
Chain
chain:1-1168
Reference Genes
BioGPS Gene:23216 TBC1D1
COSMIC (genes):TBC1D1 TBC1D1
CTD Gene:23216 TBC1D1
dbSNP Gene:23216 TBC1D1
ENSEMBL:ENSG00000065882 TBC1D1
HGNC:11578 TBC1D1
Monarch:23216 TBC1D1
NCBI Gene:23216 TBC1D1
OMIM:609850 TBC1D1
UCSC:Q86TI0 TBC1D1
Reference Transcript
Other Identifiers
11720224_a_at
11720225_a_at
11720226_s_at
11747994_a_at
11747995_x_at
11752285_a_at
1568713_3p_a_at
1568713_PM_a_at
1568713_a_at
1569566_PM_at
1569566_at
16965942
212350_PM_at
212350_at
227945_PM_at
227945_at
23216
2723758
2723759
2723760
2723769
2723770
2723771
2723781
2723782
2723783
2723786
2723787
2723807
2723808
2723809
2723813
2723814
2723815
2723816
2723817
2723818
2723823
2723824
2723827
2723831
2723832
2723833
2723834
2723835
2723837
2723839
2723840
2723841
2723843
2723860
2723861
2723862
2723869
2723872
2723877
2723878
2723879
2723885
2723886
2723887
2723889
2723890
2723891
2723892
2723893
2723897
2723910
2723911
2723912
2723913
2723920
2723921
2723922
2723923
32506_at
44004_at
79917_at
8094574
A_14_P125996
A_14_P132551
A_14_P201721
A_23_P73023
A_24_P943613
A_33_P3370812
GE62774
GE724604
GO:0005096
GO:0005515
GO:0005634
GO:0032880
GO:0043226
GO:0061179
GO:0098772
HMNXSV003041411
HMNXSV003052187
Hs.27356.0.A1_3p_at
Hs.278586.1.A1_3p_at
Hs2.203722.1.A1_3p_a_at
Hs2.203722.1.A1_3p_s_at
Hs2.203722.1.A1_3p_x_at
Hs2.203722.2.A1_3p_at
ILMN_1754947
PH_hs_0011966
PH_hs_0024215
PH_hs_0032943
TC04000214.hg
Participates
as an input of
This entity regulates
Positively
Other forms of this molecule
p-S237-TBC1D1 [cytosol]
Cross References
OpenTargets
ENSEMBL
HPA
PRO
Pharos - Targets
PDB
Interactors (32)
Accession #Entities Entities Confidence Score Evidence (IntAct)
 UniProt:P61981 YWHAG  1 0.816 7
 UniProt:Q04917 YWHAH  1 0.802 7
 UniProt:P31946 YWHAB  1 0.745 6
 UniProt:P63104 YWHAZ  2 0.745 5
 UniProt:P27348 YWHAQ  1 0.671 6
 UniProt:Q8NEU8 DP13B      0.576 4
 UniProt:P62258 YWHAE  1 0.569 4
 UniProt:P40222 TXLNA  1 0.556 3
 UniProt:Q2TBE0 CWF19L2  1 0.556 3
 UniProt:Q96T60 PNKP  1 0.556 3
 UniProt:P31273 HOXC8  1 0.556 3
 UniProt:Q96EZ8 MCRS1  1 0.556 3
 UniProt:Q6P2D0 ZFP1  1 0.556 3
 UniProt:P02585 TNNC2  1 0.556 3
 UniProt:Q5JST6 EFHC2      0.556 3
 UniProt:Q3SY00 T10IP      0.556 3
 UniProt:O95678 KRT75  1 0.556 3
 UniProt:Q8TBB1 LNX1  1 0.556 3
 UniProt:Q96IK5 GMCL1      0.556 3
 UniProt:Q8N715 CC185      0.556 3
 UniProt:Q9Y247 FA50B      0.556 3
 UniProt:Q13671 RIN1  1 0.556 3
 IntAct:EBI-16882364 CALM1      0.556 3
 UniProt:Q96C24 SYTL4  2 0.556 3
 UniProt:Q68G74 LHX8      0.556 3
 UniProt:Q8N1B4 VPS52  1 0.556 3
 UniProt:Q15560 TCEA2      0.556 3
 UniProt:Q3B820 F161A      0.556 3
 UniProt:Q9Y250 LZTS1      0.556 3
 UniProt:Q96JM7-2 L3MBTL3      0.556 3
 UniProt:O75031 HSF2B      0.556 3
 UniProt:O60293 ZC3H1      0.527 2
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