Reactome | LRP1 [plasma membrane]

LRP1 [plasma membrane]

Stable Identifier

R-HSA-1454844

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

Prolow-density lipoprotein receptor-related protein 1, LRP1_HUMAN

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Locations in the PathwayBrowser for interactor UniProt:Q9UK39 NOCT

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External Reference Information

External Reference

UniProt:Q07954 LRP1

Gene Names

LRP1, A2MR, APR

Chain

signal peptide:1-19, chain:20-4544, chain:20-3943, chain:3944-4544, chain:4441-4544

Reference Genes

BioGPS Gene:4035 LRP1

COSMIC (genes):LRP1 LRP1

CTD Gene:4035 LRP1

dbSNP Gene:4035 LRP1

ENSEMBL:ENSG00000123384 LRP1

HGNC:6692 LRP1

KEGG:hsa:4035 LRP1

Monarch:4035 LRP1

NCBI Gene:4035 LRP1

OMIM:107770 LRP1

UCSC:Q07954 LRP1

Reference Transcript

RefSeq:NM_002332.2 LRP1

Participates

as a member of

LRPs [plasma membrane] (Homo sapiens)

as a component of

LRP1:Hemopexin:heme [plasma membrane] (Homo sapiens)

as an input of

LRP1 (CD91) binds Hemopexin:heme (Homo sapiens)

Other forms of this molecule

LRP1 [endocytic vesicle membrane]

Inferred To

LRP1 [plasma membrane] (Bos taurus)

LRP1 [plasma membrane] (Canis familiaris)

LRP1 [plasma membrane] (Mus musculus)

LRP1 [plasma membrane] (Rattus norvegicus)

Cross References

OpenTargets

ENSG00000123384

ENSEMBL

ENSP00000341264, ENSP00000243077, ENST00000243077, ENSG00000123384, ENST00000338962

GeneCards

LRP1

HPA

ENSG00000123384-LRP1

PRO

Q07954

Pharos - Targets

Q07954

GlyGen

Q07954

Orphanet

LRP1

HMDB Protein

HMDBP07785

PDB

2FYL, 2FYJ, 1J8E, 2KNX, 2KNY, 1D2L, 1CR8

Interactors (40)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P30533 AMRP			0.806	5
UniProt:P02649 APOE	10	APOE [extracellular region] (R-HSA-174646) APOE [endoplasmic reticulum lumen] (R-HSA-6784908) p-APOE [endoplasmic reticulum lumen] (R-HSA-8956980) APOE [endocytic vesicle lumen] (R-HSA-3221641) APOE-4 [extracellular region] (R-HSA-9711070) APOE [plasma membrane] (R-HSA-174615) APOE [clathrin-coated endocytic vesicle membrane] (R-HSA-174651) APOE [endosome membrane] (R-HSA-174766) APOE [endosome lumen] (R-HSA-174804) APOE [early endosome] (R-HSA-2429687)	0.784	23
UniProt:O00213 APBB1	1	APBB1 [nucleoplasm] (R-HSA-5683987)	0.704	4
calcium(2+) [ChEBI:29108]	20	Ca2+ [endosome membrane] (R-ALL-5210949) Ca2+ [platelet dense granule lumen] (R-ALL-114582) Ca2+ [sarcoplasmic reticulum lumen] (R-ALL-2855229) Ca2+ [mitochondrial intermembrane space] (R-ALL-8949232) Ca2+ [lysosomal lumen] (R-ALL-1606834) Ca2+ [endocytic vesicle lumen] (R-ALL-8851519) Ca2+ [endoplasmic reticulum-Golgi intermediate compartment] (R-ALL-9706979) Ca2+ [Golgi lumen] (R-ALL-167012) Ca2+ [platelet dense tubular network lumen] (R-ALL-139827) Ca2+ [platelet dense tubular network membrane] (R-ALL-141090) Ca2+ [plasma membrane] (R-ALL-140648) Ca2+ [secretory granule lumen] (R-ALL-216801) Ca2+ [nuclear envelope] (R-ALL-2318767) Ca2+ [nucleoplasm] (R-ALL-29496) Ca2+ [mitochondrial matrix] (R-ALL-8949220) Ca2+ [mitochondrial inner membrane] (R-ALL-1524102) Ca2+ [endoplasmic reticulum membrane] (R-ALL-1500625) Ca2+ [cytosol] (R-ALL-74016) Ca2+ [extracellular region] (R-ALL-74112) Ca2+ [endoplasmic reticulum lumen] (R-ALL-111875)	0.609	4
UniProt:P11226 MBL2	1	MBL2 [extracellular region] (R-HSA-166674)	0.558	5
UniProt:Q15485 FCN2	1	FCN2 [extracellular region] (R-HSA-2530438)	0.558	2
UniProt:P00533 EGFR	20	p-6Y-EGFR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869138) p-5Y-EGFRvIII [plasma membrane] (R-HSA-1248649) EGFRvIII [plasma membrane] (R-HSA-1214162) p-6Y-EGFR E746_A750del;T790M [plasma membrane] (R-HSA-1182985) p-6Y-EGFR L858R;T790M [plasma membrane] (R-HSA-1182984) p-6Y-EGFR A767_V769dup [plasma membrane] (R-HSA-1996343) p-6Y-EGFR N771_H773dup [plasma membrane] (R-HSA-1996342) p-6Y-EGFR K739_I744dup [plasma membrane] (R-HSA-1996346) p-6Y-EGFR D770_N771insNPG [plasma membrane] (R-HSA-1996335) p-6Y-EGFR E746_A750del [plasma membrane] (R-HSA-1181214) p-6Y-EGFR L858R [plasma membrane] (R-HSA-1173211) p-6Y-EGFR G719S [plasma membrane] (R-HSA-1169417) p-6Y-EGFR L747_P753delinsS [plasma membrane] (R-HSA-1228038) p-6Y-EGFR L747_A750delinsP [plasma membrane] (R-HSA-1228044) p-6Y-EGFR L747_T751del [plasma membrane] (R-HSA-1228041) p-6Y-EGFR L747_S752del [plasma membrane] (R-HSA-1228040) p-6Y-EGFR L747_T751delinsP [plasma membrane] (R-HSA-1228042) p-6Y-EGFR E746_T751delinsA [plasma membrane] (R-HSA-1228037) p-6Y-EGFR E746_S752delinsV [plasma membrane] (R-HSA-1228039) p-6Y-EGFR L861Q [plasma membrane] (R-HSA-1177541)	0.553	2
UniProt:P49590 HARS2	1	HARS2 [mitochondrial matrix] (R-HSA-379581)	0.527	2
UniProt:Q9UK39 NOCT	1	CCRN4L [nucleoplasm] (R-HSA-508391)	0.527	2
UniProt:P11021 HSPA5	6	HSPA5 [lumenal side of endoplasmic reticulum membrane] (R-HSA-985498) HSPA5 [nucleoplasm] (R-HSA-5252042) HSPA5 [cytosol] (R-HSA-5252115) HSPA5 [endoplasmic reticulum membrane] (R-HSA-351315) HSPA5 [endoplasmic reticulum lumen] (R-HSA-387190) HSPA5 [extracellular region] (R-HSA-351322)	0.527	2
UniProt:Q6SPF0 SAMD1			0.527	2
UniProt:Q13885 TUBB2A	6	TUBB2A [cytosol] (R-HSA-191699) TUBB2A [axonemal microtubule] (R-HSA-5610431) Polyglutamyl-TUBB2A [cytosol] (R-HSA-8867392) Polyglycyl-TUBB2A [cytosol] (R-HSA-8867466) TUBB2A unfolded [cytosol] (R-HSA-392776) TUBB2A folding intermediate [cytosol] (R-HSA-392802)	0.527	2
UniProt:O94808 GFPT2	1	GFPT2 [cytosol] (R-HSA-532208)	0.527	2
UniProt:Q8N8Y5 ZFP41			0.527	2
UniProt:Q13509 TUBB3	6	TUBB3 [cytosol] (R-HSA-190532) TUBB3 [axonemal microtubule] (R-HSA-5610436) Polyglutamyl-TUBB3 [cytosol] (R-HSA-8867464) Polyglycyl-TUBB3 [cytosol] (R-HSA-8867372) TUBB3 unfolded [cytosol] (R-HSA-392770) TUBB3 folding intermediate [cytosol] (R-HSA-392806)	0.527	2
UniProt:Q3ZCM7 TUBB8	3	Polyglycyl-TUBB8 [cytosol] (R-HSA-8867423) Polyglutamyl-TUBB8 [cytosol] (R-HSA-8867387) TUBB8 [cytosol] (R-HSA-6805243)	0.527	2
UniProt:O00746 NME4	1	NME4 [mitochondrial inner membrane] (R-HSA-60026)	0.527	2
UniProt:Q6PI47 KCD18			0.527	2
UniProt:Q9H2K2 TNKS2	1	TNKS2 [cytosol] (R-HSA-3640824)	0.527	2
UniProt:O95271 TNKS	1	TNKS [cytosol] (R-HSA-3640825)	0.527	2
UniProt:P04350 TUBB4A	6	TUBB4A [cytosol] (R-HSA-190588) TUBB4A [axonemal microtubule] (R-HSA-5610435) Polyglutamyl-TUBB4A [cytosol] (R-HSA-8867425) Polyglycyl-TUBB4A [cytosol] (R-HSA-8867397) TUBB4A unfolded [cytosol] (R-HSA-392778) TUBB4A folding intermediate [cytosol] (R-HSA-392789)	0.527	2
UniProt:P12236 SLC25A6	2	SLC25A6 [mitochondrial inner membrane] (R-HSA-49745) SLC25A6 [mitochondrial intermembrane space] (R-HSA-1955374)	0.527	2
UniProt:Q71U36 TUBA1A	9	TUBA1A [cytosol] (R-HSA-191689) TUBA1A [axonemal microtubule] (R-HSA-5610433) TUBA1A(1-450) [cytosol] (R-HSA-8955577) Polyglutamyl-TUBA1A [cytosol] (R-HSA-8867408) L-isoglutamyl polyglycyl-TUBA1A [cytosol] (R-HSA-8867428) TUBA1A unfolded [cytosol] (R-HSA-392767) TUBA1A folding intermediate [cytosol] (R-HSA-392805) Ac K40 TUBA1A [axonemal microtubule] (R-HSA-5624852) AcK-TUBA1A [cytosol] (R-HSA-5618312)	0.527	2
UniProt:Q4G0M1 ERFE			0.527	2
UniProt:P62829 RPL23	1	RPL23 [cytosol] (R-HSA-72430)	0.527	2
UniProt:Q12980 NPRL3	1	NPRL3 [lysosomal membrane] (R-HSA-5490304)	0.527	2
UniProt:P21953 BCKDHB	8	p-S342-BCKDHB [mitochondrial matrix] (R-HSA-5693124) BCKDHB [mitochondrial matrix] (R-HSA-70015) Q346R BCKDHB [mitochondrial matrix] (R-HSA-9865060) R183P BCKDHB [mitochondrial matrix] (R-HSA-9865041) R170H BCKDHB [mitochondrial matrix] (R-HSA-9865071) G278S BCKDHB [mitochondrial matrix] (R-HSA-9865069) N176Y BCKDHB [mitochondrial matrix] (R-HSA-9865063) H206R BCKDHB [mitochondrial matrix] (R-HSA-9865047)	0.527	2
UniProt:Q9Y4K0 LOXL2	3	LOXL2(26-?) [extracellular region] (R-HSA-2022106) LOXL2 [extracellular region] (R-HSA-2022142) LOXL2(?-774) [extracellular region] (R-HSA-2022136)	0.527	2
UniProt:Q9H4K7 MTG2			0.527	2
UniProt:Q8TF76 HASP			0.527	2
UniProt:Q12947 FOXF2			0.527	2
UniProt:O75879 GATB			0.527	2
UniProt:Q9BV35 SCMC3			0.527	2
UniProt:P68371 TUBB4B	8	TUBB4B [cytosol] (R-HSA-191702) TUBB4B [axonemal microtubule] (R-HSA-5610441) TUBB4B [azurophil granule lumen] (R-HSA-6799347) TUBB4B [extracellular region] (R-HSA-6806178) Polyglutamyl-TUBB4B [cytosol] (R-HSA-8867427) Polyglycyl-TUBB4B [cytosol] (R-HSA-8867452) TUBB4B unfolded [cytosol] (R-HSA-392779) TUBB4B folding intermediate [cytosol] (R-HSA-392788)	0.527	2
UniProt:P68366 TUBA4A	9	TUBA4A [cytosol] (R-HSA-191694) TUBA4A [axonemal microtubule] (R-HSA-5610443) TUBA4A [extracellular region] (R-HSA-350734) Polyglutamyl-TUBA4A [cytosol] (R-HSA-8867386) L-isoglutamyl polyglycyl-TUBA4A [cytosol] (R-HSA-8867378) TUBA4A unfolded [cytosol] (R-HSA-392771) TUBA4A folding intermediate [cytosol] (R-HSA-392800) Ac K40 TUBA4A [axonemal microtubule] (R-HSA-5624859) AcK-TUBA4A [cytosol] (R-HSA-5618318)	0.527	2
UniProt:Q02742 GCNT1	1	GCNT1 [Golgi membrane] (R-HSA-914020)	0.527	2
UniProt:Q5SVS4 KMCP1			0.527	2
UniProt:Q92685 ALG3	5	ALG3 R171Q [endoplasmic reticulum membrane] (R-HSA-4720470) ALG3 M157K [endoplasmic reticulum membrane] (R-HSA-4720484) ALG3 G118D [endoplasmic reticulum membrane] (R-HSA-4720468) ALG3 W71R [endoplasmic reticulum membrane] (R-HSA-4720466) ALG3 [endoplasmic reticulum membrane] (R-HSA-449287)	0.508	2
UniProt:Q03350	4	Thbs2 [endoplasmic reticulum lumen] (R-MMU-5173187) Thbs2 [endoplasmic reticulum lumen] (R-MMU-5173234) Thbs2 [endoplasmic reticulum lumen] (R-MMU-5173111) Thbs2 [extracellular region] (R-MMU-66520)	0.499	2
UniProt:Q63722	2	Jag1 [plasma membrane] (R-RNO-9013079) Jag1 [plasma membrane] (R-RNO-157098)	0.499	4

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