p-AKT2 phosphorylates RGC2

Stable Identifier
R-HSA-1458463
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol, plasma membrane
ReviewStatus
5/5
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p-AKT2 phosphorylates RGC2
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As inferred from mouse, AKT2 (PKB-beta) phosphorylates RBC2 (RALGAPA2) on serine-486, serine-696, and threonine-715 in response to insulin. The phosphorylation prevents RBC1:RBC2 from activating RALA GTPase and allows RALA:GTP to accumulate.

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Catalyst Activity

protein serine/threonine kinase activity of p-T309,S474-AKT2 [plasma membrane]

Physical Entity
p-T309,S474-AKT2 [plasma membrane] (Homo sapiens)
Activity
protein serine/threonine kinase activity (GO:0004674)
Inferred From
Akt2 Phosphorylates Rgc2 (Mus musculus)
Authored
May, B  (2011-07-17)
Reviewed
Klip, A  (2012-08-21)
Created
May, B  (2011-07-21)
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