Reactome | GGC-RALA [cytoplasmic vesicle membrane]

GGC-RALA [cytoplasmic vesicle membrane]

Stable Identifier

R-HSA-1458479

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytoplasmic vesicle membrane

Synonyms

Ras-related protein Ral-A, RALA_HUMAN

Locations in the PathwayBrowser for interactor UniProt:P30154 PPP2R1B

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External Reference Information

External Reference

UniProt:P11233 RALA

Gene Names

RALA, RAL

Chain

chain:1-203, propeptide:204-206

Reference Genes

BioGPS Gene:5898 RALA

COSMIC (genes):RALA RALA

CTD Gene:5898 RALA

dbSNP Gene:5898 RALA

ENSEMBL:ENSG00000006451 RALA

HGNC:9839 RALA

KEGG:hsa:5898 RALA

Monarch:5898 RALA

NCBI Gene:5898 RALA

OMIM:179550 RALA

UCSC:P11233 RALA

Reference Transcript

Other Identifiers

11717756_s_at

11717757_s_at

11717758_x_at

17045369

1876_at

1877_g_at

214435_PM_x_at

214435_x_at

224880_PM_at

224880_at

2998406

2998407

2998408

2998409

2998410

2998411

2998425

2998426

2998427

2998428

2998429

2998430

2998431

2998432

2998433

2998434

2998435

2998436

3463380

39253_s_at

46237_at

5898

8132406

A_14_P116342

A_23_P168479

A_24_P192262

GE57911

GO:0000166

GO:0001843

GO:0003824

GO:0003924

GO:0003925

GO:0005515

GO:0005525

GO:0005739

GO:0005886

GO:0005925

GO:0006887

GO:0006935

GO:0007165

GO:0007265

GO:0008092

GO:0009986

GO:0016020

GO:0016192

GO:0016787

GO:0017022

GO:0017157

GO:0019003

GO:0030139

GO:0030659

GO:0031410

GO:0031623

GO:0031625

GO:0031755

GO:0032154

GO:0032956

GO:0043226

GO:0045742

GO:0051117

GO:0051301

GO:0051491

GO:0051665

GO:0070062

GO:0072655

GO:0090141

GO:0090543

GO:0097060

GO:0098685

GO:0098772

GO:0099149

HMNXSV003025909

Hs.288757.0.S1_3p_s_at

Hs.6906.0.A1_3p_at

ILMN_1755364

PH_hs_0000701

TC07000250.hg

Participates

as a component of

as an output of

Expression of Ras-related protein Ral-A (Homo sapiens)

Other forms of this molecule

RALA [cytosol]

Modified Residues

Name

S-geranylgeranyl-L-cysteine at 203

Coordinate

203

PsiMod Name

S-geranylgeranyl-L-cysteine [MOD:00113]

PsiMod Definition

A protein modification that effectively converts an L-cysteine residue to S-geranylgeranyl-L-cysteine.

Cross References

RefSeq

XP_011513768.1, XP_006715825.1, NP_005393.2

OpenTargets

ENSG00000006451

ENSEMBL

ENSP00000005257, ENST00000005257

HPA

ENSG00000006451-RALA

PRO

P11233

Pharos - Targets

P11233

PDB

8FJI, 6P0J, 6P0O, 6P0N, 6P0K, 6P0I, 2BOV, 7NQC, 1ZC3, 1ZC4, 6P0L, 6P0M, 8FJH, 2A78, 1UAD, 2A9K

Interactors (7)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q15311 RALBP1	1	RALBP1 [cytosol] (R-HSA-195194)	0.695	6
UniProt:P62158 CALM			0.593	3
UniProt:O54921	2	Exoc2 [cytosol] (R-RNO-5623376) Exoc2 [plasma membrane] (R-RNO-264887)	0.59	2
UniProt:P01112 HRAS	20	S-Farn-Me-2xPalmS HRAS [plasma membrane] (R-HSA-9647912) proHRAS [cytosol] (R-HSA-9647765) S-Farn-proHRAS [endoplasmic reticulum membrane] (R-HSA-9647918) S-Farn-HRAS [endoplasmic reticulum membrane] (R-HSA-9647788) S-Farn-Me HRAS [endoplasmic reticulum membrane] (R-HSA-9647796) S-Farn-Me PalmS HRAS [Golgi membrane] (R-HSA-9647896) S-Farn-Me HRAS [plasma membrane] (R-HSA-9665052) HRAS [plasma membrane] (R-HSA-62717) HRAS G12C [plasma membrane] (R-HSA-9656561) HRAS G12D [plasma membrane] (R-HSA-9656564) HRAS K117N [plasma membrane] (R-HSA-9656603) HRAS G13S [plasma membrane] (R-HSA-9656574) HRAS G13D [plasma membrane] (R-HSA-9656572) HRAS G13V [plasma membrane] (R-HSA-9656579) HRAS K117R [plasma membrane] (R-HSA-9656010) HRAS G13C [plasma membrane] (R-HSA-9656008) HRAS T58I [plasma membrane] (R-HSA-9656014) HRAS G12S [plasma membrane] (R-HSA-6802343) HRAS G12V [plasma membrane] (R-HSA-6802350) HRAS G13R [plasma membrane] (R-HSA-6802368)	0.571	2
UniProt:P0DTD1-PRO_0000449625 REP			0.527	2
UniProt:P30154 PPP2R1B	2	PPP2R1B [nucleoplasm] (R-HSA-166000) PPP2R1B [cytosol] (R-HSA-165980)	0.499	6
UniProt:P13569 CFTR	17	misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) CFTR [plasma membrane] (R-HSA-383188) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR G542* [plasma membrane] (R-HSA-5678986) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) ub-CFTR F508del [cytosol] (R-HSA-8866838) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR [endosome membrane] (R-HSA-6782965) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [lysosomal membrane] (R-HSA-5627279) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104)	0.483	8

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