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DEFA5(?-94) [extracellular region]
Stable Identifier
R-HSA-1462017
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
extracellular region
Synonyms
Defensin alpha 5, Defensin-5, DEF5_HUMAN, DEFA5
Locations in the PathwayBrowser for interactor UniProt:Q9NRM2 ZN277
Expand all
Immune System (Homo sapiens)
Innate Immune System (Homo sapiens)
Antimicrobial peptides (Homo sapiens)
Defensins (Homo sapiens)
Alpha-defensins (Homo sapiens)
pro-HD5 is cleaved by trypsin (Homo sapiens)
DEFA5(?-94) [extracellular region] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q01523 DEFA5
Gene Names
DEFA5, DEF5
Chain
signal peptide:1-19, peptide:20-94, peptide:23-94, peptide:29-94, peptide:56-94, peptide:63-94
Reference Genes
BioGPS Gene:1670 DEFA5
COSMIC (genes):DEFA5 DEFA5
CTD Gene:1670 DEFA5
dbSNP Gene:1670 DEFA5
ENSEMBL:ENSG00000164816 DEFA5
ENSEMBL_homo_sapiens_GENE:ENSG00000164816.8 DEFA5
ENSEMBL_homo_sapiens_GENE:ENSG00000285251.2 DEFA5
HGNC:2764 DEFA5
KEGG Gene (Homo sapiens):1670 DEFA5
Monarch:1670 DEFA5
NCBI Gene:1670 DEFA5
OMIM:600472 DEFA5
UCSC:Q01523 DEFA5
Reference Transcript
RefSeq:NM_021010.2 DEFA5
Other Identifiers
11728641_at
11728642_s_at
1670
17074336
207529_PM_at
207529_at
3122829
3122830
3122831
3122832
3122833
34623_at
8149142
GE58181
GO:0002227
GO:0002376
GO:0005515
GO:0005576
GO:0005615
GO:0005794
GO:0005796
GO:0006952
GO:0019731
GO:0030133
GO:0030141
GO:0030496
GO:0031410
GO:0031640
GO:0032757
GO:0034774
GO:0042742
GO:0042803
GO:0043226
GO:0043231
GO:0045087
GO:0050829
GO:0050830
GO:0050832
GO:0051289
GO:0051673
GO:0051873
GO:0061844
GO:0065003
GO:0071222
GO:0098542
GO:1905710
HMNXSV003031842
ILMN_1770424
M97925_rna1_at
TC08000914.hg
g10337584_3p_at
Participates
as an output of
pro-HD5 is cleaved by trypsin (Homo sapiens)
as a member of
Alpha-defensins [extracellular region] (Homo sapiens)
as a component of
Defensin-5 dimer [extracellular region] (Homo sapiens)
Other forms of this molecule
DEFA5(1-94) [Golgi lumen]
DEFA5(20-94) [Golgi lumen]
DEFA5(20-94) [secretory granule lumen]
DEFA5(20-94) [extracellular region]
Inferred To
Defa35 [extracellular region]
(Mus musculus)
Defa28 [extracellular region]
(Mus musculus)
Defa31 [extracellular region]
(Mus musculus)
Defa40 [extracellular region]
(Mus musculus)
Defa2 [extracellular region]
(Mus musculus)
Defa26 [extracellular region]
(Mus musculus)
Defa [extracellular region]
(Rattus norvegicus)
Defa23 [extracellular region]
(Mus musculus)
Defa39 [extracellular region]
(Mus musculus)
Defa42 [extracellular region]
(Mus musculus)
Defa21 [extracellular region]
(Mus musculus)
Defa25 [extracellular region]
(Mus musculus)
Homologues of DEFA5(?-94) [extracellular region]
(Mus musculus)
Defa29 [extracellular region]
(Mus musculus)
Defa34 [extracellular region]
(Mus musculus)
Defa30 [extracellular region]
(Mus musculus)
Defa3 [extracellular region]
(Mus musculus)
Defa5 [extracellular region]
(Mus musculus)
Defa38 [extracellular region]
(Mus musculus)
Defa22 [extracellular region]
(Mus musculus)
Defa24 [extracellular region]
(Mus musculus)
Defa17 [extracellular region]
(Mus musculus)
Defa41 [extracellular region]
(Mus musculus)
Defa20 [extracellular region]
(Mus musculus)
Defa36 [extracellular region]
(Mus musculus)
AY761185 [extracellular region]
(Mus musculus)
DEFA5(?-94) [extracellular region]
(Mus musculus)
Cross References
RefSeq
NP_066290.1
OpenTargets
ENSG00000164816
GeneCards
Q01523
HPA
ENSG00000164816-DEFA5
Ensembl
ENST00000647159
,
ENST00000330590
,
ENSP00000494799
,
ENSG00000285251
,
ENSP00000329890
,
ENSG00000164816
PRO
Q01523
Pharos - Targets
Q01523
PDB
2MIT
,
4E86
,
5CUJ
,
3I5W
,
4E82
,
1ZMP
,
5CUI
,
4RBX
,
4E83
,
2LXZ
,
4RBW
,
5CUM
Interactors (35)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q6FHY5 Q6FHY5
0.556
3
UniProt:Q9UIW2 PLXNA1
2
p-Y-PLXNA1 [plasma membrane]
(R-HSA-419614)
PLXNA1 [plasma membrane]
(R-HSA-396932)
0.527
2
UniProt:P11498 PC
3
Btn-PC [cytosol]
(R-HSA-3323170)
PC [cytosol]
(R-HSA-3323119)
Btn-PC [mitochondrial matrix]
(R-HSA-2993804)
0.527
2
UniProt:O75051 PLXNA2
2
PLXNA2 [plasma membrane]
(R-HSA-396934)
p-Y-PLXNA2 [plasma membrane]
(R-HSA-419607)
0.527
2
UniProt:Q92743 HTRA1
1
HTRA1 [extracellular region]
(R-HSA-8855820)
0.527
2
UniProt:P35226 BMI1
3
BMI1 [nucleoplasm]
(R-HSA-389121)
p-S-BMI1 [nucleoplasm]
(R-HSA-3229116)
monoSUMO1-K88-BMI1 [nucleoplasm]
(R-HSA-4551729)
0.527
2
UniProt:Q9NWM8 FKBP14 gene
1
FKBP14 [endoplasmic reticulum lumen]
(R-HSA-535607)
0.527
2
UniProt:Q9NRM2 ZN277
0.527
2
UniProt:O75973 C1QRF
0.527
2
UniProt:O15031 PLXB2
0.527
2
UniProt:Q86Z23 C1QL4
0.527
2
UniProt:P23396 RPS3
2
RPS3 [nucleoplasm]
(R-HSA-6798714)
RPS3 [cytosol]
(R-HSA-72369)
0.527
2
UniProt:O75815 BCAR3
0.527
2
UniProt:Q86T24 KAISO
0.527
2
UniProt:Q9Y4K0 LOXL2
3
LOXL2(26-?) [extracellular region]
(R-HSA-2022106)
LOXL2 [extracellular region]
(R-HSA-2022142)
LOXL2(?-774) [extracellular region]
(R-HSA-2022136)
0.527
2
UniProt:O60279 SUSD5
0.527
2
UniProt:Q14766 LTBP1
3
p-LTBP1 [endoplasmic reticulum lumen]
(R-HSA-8957050)
LTBP1 [endoplasmic reticulum lumen]
(R-HSA-8956770)
LTBP1 [extracellular region]
(R-HSA-2161391)
0.527
2
UniProt:Q8WTP9 XAGE3
0.527
2
UniProt:Q92551 IP6K1
2
IP6K1 [cytosol]
(R-HSA-1604591)
IP6K1 [nucleoplasm]
(R-HSA-2023952)
0.527
2
UniProt:Q9NRJ7 PCDBG
0.527
2
UniProt:P83731 RPL24
1
RPL24 [cytosol]
(R-HSA-72434)
0.527
2
UniProt:Q8IUL8 CILP2
0.527
2
UniProt:Q641Q3 METRL
0.527
2
UniProt:Q9UF33 EPHA6
2
EPHA6 [plasma membrane]
(R-HSA-2682332)
p-Y606,Y612-EPHA6 [plasma membrane]
(R-HSA-3928368)
0.527
2
UniProt:Q9BXX0 EMILIN2
1
EMILIN2 [extracellular region]
(R-HSA-2161394)
0.527
2
UniProt:P49411 TUFM
2
TUFM [mitochondrial matrix]
(R-HSA-5389846)
TUFM [mitochondrial outer membrane]
(R-HSA-9754777)
0.527
2
UniProt:Q29983 MICA
1
MICA [plasma membrane]
(R-HSA-5696432)
0.527
2
UniProt:Q86XX4 FRAS1
0.527
2
UniProt:Q9HBH1 DEFM
0.527
2
UniProt:O60243 HS6ST1
1
HS6ST1 [Golgi membrane]
(R-HSA-2076504)
0.527
2
UniProt:Q0VDF9 HSPA14
2
HSPA14 [cytosol]
(R-HSA-5251948)
HSPA14 [nucleoplasm]
(R-HSA-5252082)
0.527
2
UniProt:P42336 PIK3CA
20
PIK3CA H1047L [cytosol]
(R-HSA-1500714)
PIK3CA H1047R [cytosol]
(R-HSA-1500716)
PIK3CA M1043I [cytosol]
(R-HSA-1500719)
PIK3CA M1043T [cytosol]
(R-HSA-2395934)
PIK3CA M1043V [cytosol]
(R-HSA-2395932)
PIK3CA H1047Y [cytosol]
(R-HSA-1500720)
PIK3CA E542K [cytosol]
(R-HSA-1500701)
PIK3CA Q546K [cytosol]
(R-HSA-1500705)
PIK3CA E545A [cytosol]
(R-HSA-2362355)
PIK3CA E545K [cytosol]
(R-HSA-1500706)
PIK3CA E545Q [cytosol]
(R-HSA-2362362)
PIK3CA Q546E [cytosol]
(R-HSA-2362383)
PIK3CA E545V [cytosol]
(R-HSA-2362365)
PIK3CA E542V [cytosol]
(R-HSA-2328074)
PIK3CA Q546L [cytosol]
(R-HSA-2362375)
PIK3CA E545G [cytosol]
(R-HSA-1500709)
PIK3CA Q546H [cytosol]
(R-HSA-2362374)
PIK3CA Q546R [cytosol]
(R-HSA-2362373)
PIK3CA Q546P [cytosol]
(R-HSA-1500695)
PIK3CA E542Q [cytosol]
(R-HSA-2328003)
0.527
2
UniProt:O94923 GLCE
1
GLCE [Golgi membrane]
(R-HSA-2024106)
0.527
2
UniProt:A8MXV4 NUDT19
2
NUDT19 [cytosol]
(R-HSA-9033098)
NUDT19 [peroxisomal matrix]
(R-HSA-6809219)
0.527
2
UniProt:Q8NBN7 RDH13
1
RDH13 [mitochondrial inner membrane]
(R-HSA-2980995)
0.527
2
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