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DEFA1(65-94) [extracellular region]
Stable Identifier
R-HSA-1462022
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
extracellular region
Synonyms
Defensin alpha 1, DEFA1, Neutrophil defensin 1, DEF1_HUMAN, HNP-1
Locations in the PathwayBrowser
Expand all
Immune System (Homo sapiens)
Innate Immune System (Homo sapiens)
Antimicrobial peptides (Homo sapiens)
Defensins (Homo sapiens)
Alpha-defensins (Homo sapiens)
ADP-Ribosylation of HNP-1 (Homo sapiens)
DEFA1(65-94) [extracellular region] (Homo sapiens)
Alpha-defensin dimers adsorb onto microbial membrane anionic phospholipids (Homo sapiens)
Alpha-defensin dimers [extracellular region] (Homo sapiens)
Defensin alpha 1 dimer [extracellular region] (Homo sapiens)
DEFA1(65-94) [extracellular region] (Homo sapiens)
Alpha-defensin dimers:anionic phospholipids [plasma membrane] (Homo sapiens)
Alpha-defensin dimers [extracellular region] (Homo sapiens)
Defensin alpha 1 dimer [extracellular region] (Homo sapiens)
DEFA1(65-94) [extracellular region] (Homo sapiens)
Alpha-defensin dimers multimerize to form a pore complex (Homo sapiens)
Alpha-defensin dimers:anionic phospholipids [plasma membrane] (Homo sapiens)
Alpha-defensin dimers [extracellular region] (Homo sapiens)
Defensin alpha 1 dimer [extracellular region] (Homo sapiens)
DEFA1(65-94) [extracellular region] (Homo sapiens)
Alpha-defensin pore complex [plasma membrane] (Homo sapiens)
Alpha-defensin dimers:anionic phospholipids [plasma membrane] (Homo sapiens)
Alpha-defensin dimers [extracellular region] (Homo sapiens)
Defensin alpha 1 dimer [extracellular region] (Homo sapiens)
DEFA1(65-94) [extracellular region] (Homo sapiens)
Alpha-defensins form biologically active dimers (Homo sapiens)
Alpha-defensin dimers [extracellular region] (Homo sapiens)
Defensin alpha 1 dimer [extracellular region] (Homo sapiens)
DEFA1(65-94) [extracellular region] (Homo sapiens)
Alpha-defensins [extracellular region] (Homo sapiens)
DEFA1(65-94) [extracellular region] (Homo sapiens)
HNP1-4 are released into phagocytic vacuoles (Homo sapiens)
Defensins alpha 1-4 [extracellular region] (Homo sapiens)
DEFA1(65-94) [extracellular region] (Homo sapiens)
Binding of defensins to lipid II (Homo sapiens)
Defensins that bind Lipid II [extracellular region] (Homo sapiens)
DEFA1(65-94) [extracellular region] (Homo sapiens)
Defensins that bind Lipid II:Lipid II [plasma membrane] (Homo sapiens)
Defensins that bind Lipid II [extracellular region] (Homo sapiens)
DEFA1(65-94) [extracellular region] (Homo sapiens)
Neutrophil degranulation (Homo sapiens)
Exocytosis of azurophil granule lumen proteins (Homo sapiens)
Azurophil granule lumen proteins [extracellular region] (Homo sapiens)
DEFA1(65-94) [extracellular region] (Homo sapiens)
External Reference Information
External Reference
UniProt:P59665 DEFA1
Gene Names
DEFA1, DEF1, DEFA2, MRS, DEFA1B
Chain
signal peptide:1-19, propeptide:20-38, chain:39-94, peptide:65-94, peptide:66-94
Reference Genes
BioGPS Gene:1667 DEFA1
BioGPS Gene:728358 DEFA1
COSMIC (genes):DEFA1 DEFA1
CTD Gene:1667 DEFA1
CTD Gene:728358 DEFA1
dbSNP Gene:1667 DEFA1
dbSNP Gene:728358 DEFA1
ENSEMBL:ENSG00000206047 DEFA1
ENSEMBL:ENSG00000240247 DEFA1
ENSEMBL_homo_sapiens_GENE:ENSG00000206047.4 DEFA1
ENSEMBL_homo_sapiens_GENE:ENSG00000240247.8 DEFA1
ENSEMBL_homo_sapiens_GENE:ENSG00000284983.2 DEFA1
ENSEMBL_homo_sapiens_GENE:ENSG00000285176.2 DEFA1
HGNC:2761 DEFA1
HGNC:33596 DEFA1
KEGG Gene (Homo sapiens):1667 DEFA1
KEGG Gene (Homo sapiens):728358 DEFA1
Monarch:1667 DEFA1
Monarch:728358 DEFA1
NCBI Gene:1667 DEFA1
NCBI Gene:728358 DEFA1
OMIM:125220 DEFA1
UCSC:P59665 DEFA1
Reference Transcript
RefSeq:NM_001042500.1 DEFA1
RefSeq:NM_004084.3 DEFA1
Other Identifiers
11721438_s_at
1667
17074313
17074322
205033_PM_s_at
205033_s_at
3122764
3122765
3122766
3122772
3122785
3122786
3122787
3122793
3122806
3122807
3122808
3122813
31506_s_at
31793_at
728358
8149116
8149126
8149137
A_23_P31816
GO:0002227
GO:0002376
GO:0005515
GO:0005576
GO:0005615
GO:0005764
GO:0005773
GO:0005794
GO:0005796
GO:0006935
GO:0006952
GO:0006955
GO:0010818
GO:0019731
GO:0023052
GO:0030312
GO:0030520
GO:0031012
GO:0031410
GO:0031640
GO:0035578
GO:0042742
GO:0042832
GO:0043226
GO:0048870
GO:0050829
GO:0050830
GO:0050832
GO:0051607
GO:0051673
GO:0051873
GO:0061844
GO:0062023
GO:0070062
GO:0071222
GO:0098542
GO:0140911
HMNXSV003020261
ILMN_1679357
ILMN_1725661
ILMN_2102721
ILMN_2165289
ILMN_2193213
M26602_at
PH_hs_0030636
TC08000910.hg
TC08002630.hg
TC08002631.hg
g12621915_3p_s_at
Participates
as a member of
Azurophil granule lumen proteins [extracellular region] (Homo sapiens)
Defensins that bind Lipid II [extracellular region] (Homo sapiens)
Alpha-defensins [extracellular region] (Homo sapiens)
Defensins alpha 1-4 [extracellular region] (Homo sapiens)
as an input of
ADP-Ribosylation of HNP-1 (Homo sapiens)
as a component of
Defensin alpha 1 dimer [extracellular region] (Homo sapiens)
Other forms of this molecule
DEFA1(65-94) [azurophil granule lumen]
omega-N-(ADP-ribosyl)-L-arginine-DEFA1(65-94) [extracellular region]
DEFA1(66-94) [azurophil granule lumen]
DEFA1(66-94) [extracellular region]
DEFA1(20-65) [Golgi lumen]
DEFA1(66-94) [Golgi lumen]
DEFA1(20-94) [Golgi lumen]
DEFA1(1-94) [Golgi lumen]
Inferred To
Defa35 [extracellular region]
(Mus musculus)
Defa28 [extracellular region]
(Mus musculus)
Defa31 [extracellular region]
(Mus musculus)
Defa40 [extracellular region]
(Mus musculus)
Np4 [extracellular region]
(Rattus norvegicus)
Defa2 [extracellular region]
(Mus musculus)
Defa26 [extracellular region]
(Mus musculus)
Defa10 [extracellular region]
(Rattus norvegicus)
Homologues of DEFA1(65-94) [extracellular region]
(Mus musculus)
Homologues of DEFA1(65-94) [extracellular region]
(Rattus norvegicus)
Defa9 [extracellular region]
(Rattus norvegicus)
Defal1 [extracellular region]
(Rattus norvegicus)
Defa [extracellular region]
(Rattus norvegicus)
Defa23 [extracellular region]
(Mus musculus)
Defa39 [extracellular region]
(Mus musculus)
Defa42 [extracellular region]
(Mus musculus)
Defa21 [extracellular region]
(Mus musculus)
Defa25 [extracellular region]
(Mus musculus)
Defa29 [extracellular region]
(Mus musculus)
Defa34 [extracellular region]
(Mus musculus)
Defa8 [extracellular region]
(Rattus norvegicus)
Defa30 [extracellular region]
(Mus musculus)
Defa11 [extracellular region]
(Rattus norvegicus)
Defa3 [extracellular region]
(Mus musculus)
Defa6 [extracellular region]
(Rattus norvegicus)
ENSRNOG00000064390 [extracellular region]
(Rattus norvegicus)
Defa5 [extracellular region]
(Mus musculus)
DEFA1(65-94) [extracellular region]
(Mus musculus)
DEFA1(65-94) [extracellular region]
(Rattus norvegicus)
Defa38 [extracellular region]
(Mus musculus)
Defa22 [extracellular region]
(Mus musculus)
Defa24 [extracellular region]
(Mus musculus)
Defa24 [extracellular region]
(Rattus norvegicus)
Defa17 [extracellular region]
(Mus musculus)
Defa41 [extracellular region]
(Mus musculus)
Defa20 [extracellular region]
(Mus musculus)
Defa36 [extracellular region]
(Mus musculus)
AY761185 [extracellular region]
(Mus musculus)
Cross References
RefSeq
NP_001035965.1
,
NP_004075.1
OpenTargets
ENSG00000206047
HPA
ENSG00000240247-DEFA1B
,
ENSG00000206047-DEFA1
GeneCards
P59665
Ensembl
ENSP00000496578
,
ENSP00000493747
,
ENST00000382689
,
ENSG00000284983
,
ENSG00000206047
,
ENST00000382692
,
ENSP00000372136
,
ENST00000644528
,
ENST00000645146
,
ENSG00000240247
,
ENSP00000372139
,
ENSG00000285176
PRO
P59665
Pharos - Targets
P59665
PDB
3LO2
,
4LBB
,
3LO1
,
3LVX
,
4LBF
,
4LB1
,
3LO9
,
3HJ2
,
3H6C
,
4LB7
,
3LO6
,
4DU0
,
3GNY
,
3LO4
,
3HJD
,
2PM1
,
2KHT
,
3LOE
Interactors (43)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q9UHD9 UBQLN2
1
UBQLN2 [cytosol]
(R-HSA-8866007)
0.556
3
UniProt:Q9UIW2 PLXNA1
2
p-Y-PLXNA1 [plasma membrane]
(R-HSA-419614)
PLXNA1 [plasma membrane]
(R-HSA-396932)
0.527
2
UniProt:Q01459 DIAC
0.527
2
UniProt:O75051 PLXNA2
2
PLXNA2 [plasma membrane]
(R-HSA-396934)
p-Y-PLXNA2 [plasma membrane]
(R-HSA-419607)
0.527
2
UniProt:Q92545 TM131
0.527
2
UniProt:P13497 BMP1
1
BMP1 [extracellular region]
(R-HSA-2002393)
0.527
2
UniProt:O75976 CPD
3
CPD [Golgi membrane]
(R-HSA-432675)
CPD [cytoplasmic vesicle membrane]
(R-HSA-432671)
CPD [plasma membrane]
(R-HSA-9715182)
0.527
2
UniProt:P12109 COL6A1
20
GalHyl-COL6A1 [endoplasmic reticulum lumen]
(R-HSA-2023521)
3x4Hyp-GlcGalHyl-COL6A1 [endoplasmic reticulum lumen]
(R-HSA-2023651)
GlcGalHyl-COL6A1 [endoplasmic reticulum lumen]
(R-HSA-2023608)
3x4Hyp-GalHyl-COL6A1 [endoplasmic reticulum lumen]
(R-HSA-2023576)
3x4Hyp-3Hyp-GalHyl-COL6A1 [endoplasmic reticulum lumen]
(R-HSA-2023560)
3x4Hyp-3Hyp-GlcGalHyl-COL6A1 [endoplasmic reticulum lumen]
(R-HSA-2023660)
COL6A1 [endoplasmic reticulum lumen]
(R-HSA-1614453)
3x4Hyp-COL6A1 [endoplasmic reticulum lumen]
(R-HSA-2022508)
3x4Hyp-3Hyp-COL6A1 [endoplasmic reticulum lumen]
(R-HSA-2022507)
3x4Hyp-5Hyl-COL6A1 [endoplasmic reticulum lumen]
(R-HSA-2022965)
3x4Hyp-3Hyp-5Hyl-COL6A1 [endoplasmic reticulum lumen]
(R-HSA-2022944)
5Hyl-COL6A1 [endoplasmic reticulum lumen]
(R-HSA-2022997)
3x4Hyp-COL6A1(?-1028) [extracellular region]
(R-HSA-2470138)
COL6A1(?-1028) [extracellular region]
(R-HSA-2470040)
3x4Hyp-COL6A1(20-?) [extracellular region]
(R-HSA-2470073)
GalHyl-COL6A1(20-?) [extracellular region]
(R-HSA-2470046)
3x4Hyp-5Hyl-COL6A1(?-1028) [extracellular region]
(R-HSA-2470143)
3x4Hyp-3Hyp-5Hyl-COL6A1(20-?) [extracellular region]
(R-HSA-2470066)
GlcGalHyl-COL6A1(20-?) [extracellular region]
(R-HSA-2470033)
3x4Hyp-3Hyp-GalHyl-COL6A1(?-1028) [extracellular region]
(R-HSA-2470103)
0.527
2
UniProt:P63098 PPP3R1
2
PPP3R1 [nucleoplasm]
(R-HSA-2685631)
PPP3R1 [cytosol]
(R-HSA-51291)
0.527
2
UniProt:P30532 CHRNA5
1
CHRNA5 [plasma membrane]
(R-HSA-507833)
0.527
2
UniProt:O15230 LAMA5
3
LAMA5(?-3695) [extracellular region]
(R-HSA-3791178)
LAMA5(36-?) [extracellular region]
(R-HSA-3791176)
LAMA5 [extracellular region]
(R-HSA-215956)
0.527
2
UniProt:O15031 PLXB2
0.527
2
UniProt:P48454 PPP3CC
1
PPP3CC [cytosol]
(R-HSA-61113)
0.527
2
UniProt:Q9BZ76 CNTP3
0.527
2
UniProt:Q7Z6J8 UBE3D
1
UBE3D [cytosol]
(R-HSA-8851647)
0.527
2
UniProt:Q9Y4K0 LOXL2
3
LOXL2(26-?) [extracellular region]
(R-HSA-2022106)
LOXL2 [extracellular region]
(R-HSA-2022142)
LOXL2(?-774) [extracellular region]
(R-HSA-2022136)
0.527
2
UniProt:P55268 LAMB2
3
p-LAMB2 [endoplasmic reticulum lumen]
(R-HSA-8957053)
LAMB2 [endoplasmic reticulum lumen]
(R-HSA-8956752)
LAMB2 [extracellular region]
(R-HSA-215961)
0.527
2
UniProt:Q92626 PXDN
1
PXDN [extracellular region]
(R-HSA-2559628)
0.527
2
UniProt:P07942 LAMB1
3
p-LAMB1 [endoplasmic reticulum lumen]
(R-HSA-8956889)
LAMB1 [endoplasmic reticulum lumen]
(R-HSA-8956706)
LAMB1 [extracellular region]
(R-HSA-215959)
0.527
2
UniProt:Q16787 LAMA3
3
LAMA3(36-?) [extracellular region]
(R-HSA-2533899)
LAMA3(?-3333) [extracellular region]
(R-HSA-2533924)
LAMA3 [extracellular region]
(R-HSA-445991)
0.527
2
UniProt:P42702 LIFR
1
LIFR [plasma membrane]
(R-HSA-5693181)
0.527
2
UniProt:O00462 MANBA
3
MANBA [plasma membrane]
(R-HSA-6806257)
MANBA [azurophil granule membrane]
(R-HSA-6799128)
MANBA [lysosomal lumen]
(R-HSA-8853711)
0.527
2
UniProt:Q8IUL8 CILP2
0.527
2
UniProt:P06276 BCHE
2
BCHE [extracellular region]
(R-HSA-434469)
BCHE [plasma membrane]
(R-HSA-3640835)
0.527
2
UniProt:Q9UBX1 CTSF
1
CTSF [lysosomal lumen]
(R-HSA-1181231)
0.527
2
UniProt:P15848 ARSB
12
ARSB Y86del [lysosomal lumen]
(R-HSA-2314606)
ARSB C117R [lysosomal lumen]
(R-HSA-2314618)
ARSB [endoplasmic reticulum lumen]
(R-HSA-1614331)
OxA-ARSB [endoplasmic reticulum lumen]
(R-HSA-1614325)
ARSB [azurophil granule lumen]
(R-HSA-6798774)
ARSB [extracellular region]
(R-HSA-6806236)
ARSB [ficolin-1-rich granule lumen]
(R-HSA-6800887)
OxA-ARSB [lysosomal lumen]
(R-HSA-1606837)
ARSB H393P [lysosomal lumen]
(R-HSA-5649492)
ARSB R95Q [lysosomal lumen]
(R-HSA-2314614)
ARSB G144R [lysosomal lumen]
(R-HSA-2314612)
ARSB P116H [lysosomal lumen]
(R-HSA-2314619)
0.527
2
UniProt:O95158 NXPH4
0.527
2
UniProt:P01137 TGFB1
7
TGFB1 [extracellular region]
(R-HSA-170838)
TGFB1(30-278) [extracellular region]
(R-HSA-2395367)
TGFB1(30-278) [Golgi lumen]
(R-HSA-9736812)
TGFB1 [Golgi lumen]
(R-HSA-177108)
TGFB1(30-390) [Golgi lumen]
(R-HSA-114705)
TGFB1 [plasma membrane]
(R-HSA-5146781)
TGFB1(30-278) [platelet alpha granule lumen]
(R-HSA-65936)
0.527
2
UniProt:P28799 GRN
2
GRN [azurophil granule lumen]
(R-HSA-6799168)
GRN [extracellular region]
(R-HSA-6806217)
0.527
2
UniProt:Q5HYA8 TMEM67
1
TMEM67 [ciliary membrane]
(R-HSA-5626667)
0.527
2
UniProt:O43405 COCH
0.527
2
UniProt:Q9BSG0 PADC1
0.527
2
UniProt:Q9BZQ6 EDEM3
1
EDEM3 [endoplasmic reticulum quality control compartment]
(R-HSA-1022110)
0.527
2
UniProt:Q13683 ITGA7
1
ITGA7(34-1181) [plasma membrane]
(R-HSA-215940)
0.527
2
UniProt:O60243 HS6ST1
1
HS6ST1 [Golgi membrane]
(R-HSA-2076504)
0.527
2
UniProt:O94813 SLIT2
3
SLIT2(31-1121) [extracellular region]
(R-HSA-426409)
SLIT2(1122-1529) [extracellular region]
(R-HSA-426412)
SLIT2 [extracellular region]
(R-HSA-375997)
0.527
2
UniProt:P61916 NPC2
3
NPC2 [lysosomal lumen]
(R-HSA-8876488)
NPC2 [extracellular region]
(R-HSA-6806224)
NPC2 [azurophil granule lumen]
(R-HSA-6799163)
0.527
2
UniProt:Q99538 LGMN
2
LGMN [lysosomal lumen]
(R-HSA-350135)
LGMN [endolysosome lumen]
(R-HSA-8942384)
0.527
2
UniProt:P18065 IGFBP2
1
IGFBP2 [extracellular region]
(R-HSA-381402)
0.527
2
UniProt:Q9UM47 NOTCH3
20
Ub-NICD3 [cytosol]
(R-HSA-9021546)
Ub-NEXT3 [plasma membrane]
(R-HSA-9021545)
p-Y-NICD3 [cytosol]
(R-HSA-9018581)
Glc,GlcNAc-Fuc-Pre-NOTCH3 [Golgi membrane]
(R-HSA-1911429)
Glc,Gal-GlcNAc-Fuc-Pre-NOTCH3 [Golgi membrane]
(R-HSA-1911419)
Glc,Sia-Gal-GlcNAc-Fuc-Pre-NOTCH3 [Golgi membrane]
(R-HSA-1911504)
FRINGE-modified NOTCH3 Extracellular Fragment (NECD3) [plasma membrane]
(R-HSA-1911517)
FRINGE-modified NOTCH3 Extracellular fragment (NECD3) [Golgi membrane]
(R-HSA-1911522)
NOTCH3(40-1628) [extracellular region]
(R-HSA-157639)
NOTCH3(1629-1661) [plasma membrane]
(R-HSA-157657)
NEXT3 [plasma membrane]
(R-HSA-157203)
NICD3 [cytosol]
(R-HSA-157647)
NICD3 [nucleoplasm]
(R-HSA-157928)
Pre-NOTCH3 [endoplasmic reticulum membrane]
(R-HSA-157102)
10xFucT-4xFucS-NOTCH3(40-2321) [endoplasmic reticulum membrane]
(R-HSA-1467382)
14xGlcS-10xFucT-4xFucS-NOTCH3(40-2321) [endoplasmic reticulum membrane]
(R-HSA-1467307)
14xGlcS-10xFucT-4xFucS-NOTCH3(40-2321) [Golgi membrane]
(R-HSA-1472871)
NOTCH3(1572-2321) [plasma membrane]
(R-HSA-157231)
14xGlcS-10xFucT-4xFucS-NOTCH3(40-1571) [extracellular region]
(R-HSA-1983675)
14xGlcS-10xFucT-4xFucS-NOTCH3(40-1571) [Golgi membrane]
(R-HSA-1983672)
0.527
2
UniProt:P13639 EEF2
10
EEF2 [ficolin-1-rich granule lumen]
(R-HSA-6801513)
EEF2 [extracellular region]
(R-HSA-6806499)
EEF2 [secretory granule lumen]
(R-HSA-6801504)
EEF2 [cytosol]
(R-HSA-156901)
aminocarboxypropyl EEF2 [cytosol]
(R-HSA-5358478)
Me-diphthine EEF2 [cytosol]
(R-HSA-5367025)
nascent EEF2 [cytosol]
(R-HSA-5358472)
diphthine EEF2 [cytosol]
(R-HSA-5358501)
ADP-ribo-EEF2 [cytosol]
(R-HSA-5334764)
Me3K525-EEF2 [cytosol]
(R-HSA-8932237)
0.527
2
UniProt:Q9BT09 CNPY3
1
CNPY3 [endoplasmic reticulum lumen]
(R-HSA-1678932)
0.527
2
UniProt:Q3LXA3 TKFC
1
TKFC [cytosol]
(R-HSA-918185)
0.527
2
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