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Disialyl T-antigen (MUC1) [Golgi lumen]
Stable Identifier
R-HSA-1463518
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
Golgi lumen
Synonyms
MUC1, MUC1_HUMAN
Icon
Locations in the PathwayBrowser
Expand all
Metabolism of proteins (Homo sapiens)
Post-translational protein modification (Homo sapiens)
O-linked glycosylation (Homo sapiens)
O-linked glycosylation of mucins (Homo sapiens)
Termination of O-glycan biosynthesis (Homo sapiens)
ST6GALNAC3/4 transfers sialic acid to the sialyl T antigen to form the disialyl T antigen (Homo sapiens)
Disialyl T antigens [Golgi lumen] (Homo sapiens)
Disialyl T-antigen (MUC1) [Golgi lumen] (Homo sapiens)
External Reference Information
External Reference
UniProt:P15941 MUC1
Gene Names
MUC1, PUM
Chain
signal peptide:1-23, chain:24-1255, chain:24-1097, chain:1098-1255
Reference Genes
BioGPS Gene:4582 MUC1
COSMIC (genes):MUC1 MUC1
CTD Gene:4582 MUC1
dbSNP Gene:4582 MUC1
ENSEMBL:ENSG00000185499 MUC1
ENSEMBL_homo_sapiens_GENE:ENSG00000185499.17 MUC1
HGNC:7508 MUC1
KEGG Gene (Homo sapiens):4582 MUC1
Monarch:4582 MUC1
NCBI Gene:4582 MUC1
OMIM:158340 MUC1
UCSC:P15941 MUC1
Reference Transcript
RefSeq:NM_001018017.2 MUC1
RefSeq:NM_001204286.1 MUC1
RefSeq:NM_001204285.1 MUC1
RefSeq:NM_001044393.2 MUC1
RefSeq:NM_001204290.1 MUC1
RefSeq:NM_001204289.1 MUC1
RefSeq:NM_001204294.1 MUC1
RefSeq:NM_001018016.2 MUC1
RefSeq:NM_001204293.1 MUC1
RefSeq:NM_002456.5 MUC1
RefSeq:NM_001204297.1 MUC1
RefSeq:NM_001044392.2 MUC1
RefSeq:NM_001044391.2 MUC1
RefSeq:NM_001204288.1 MUC1
RefSeq:NM_001204287.1 MUC1
RefSeq:NM_001204292.1 MUC1
RefSeq:NM_001204291.1 MUC1
RefSeq:NM_001204296.1 MUC1
RefSeq:NM_001204295.1 MUC1
RefSeq:NM_001044390.2 MUC1
Other Identifiers
11738366_x_at
11745158_x_at
11750536_x_at
11753640_x_at
11753651_x_at
11753678_x_at
11753692_x_at
11753818_x_at
11753973_x_at
11762687_x_at
16693976
207847_PM_s_at
207847_s_at
211695_PM_x_at
211695_x_at
213693_PM_s_at
213693_s_at
2437119
2437120
2437124
2437125
2437127
2437128
2437130
2437131
2437134
2437136
2437137
2437147
2437148
2437149
2437150
2437151
38783_at
38784_g_at
4582
700_s_at
7920642
927_s_at
A_33_P3332215
GE542853
GO:0000278
GO:0000785
GO:0000978
GO:0002039
GO:0003677
GO:0003712
GO:0005515
GO:0005576
GO:0005615
GO:0005634
GO:0005694
GO:0005737
GO:0005794
GO:0005796
GO:0005886
GO:0006351
GO:0006355
GO:0006977
GO:0007155
GO:0010944
GO:0012501
GO:0016020
GO:0016324
GO:0023052
GO:0030330
GO:0031982
GO:0033629
GO:0043226
GO:0045944
GO:0051179
GO:0070062
GO:0140110
GO:1902166
Hs.89603.6.A1_3p_a_at
ILMN_1677314
ILMN_1756992
ILMN_2371911
J05582_s_at
PH_hs_0005002
TC01005848.hg
g4505282_3p_s_at
Participates
as a member of
Disialyl T antigens [Golgi lumen] (Homo sapiens)
Other forms of this molecule
MUC1(24-1255) [plasma membrane]
Core 8 (MUC1) [Golgi lumen]
Core 2S (MUC1) [Golgi lumen]
Core 5 (MUC1) [Golgi lumen]
Core 4 (MUC1) [Golgi lumen]
Core 3 (MUC1) [Golgi lumen]
Core 7 (MUC1) [Golgi lumen]
extended Core 6 (MUC1) [Golgi lumen]
Core 6 (MUC1) [Golgi lumen]
MUC1(24-1255) [Golgi lumen]
Sialyl T-antigen (MUC1) [Golgi lumen]
Sialyl-2,3 T-antigen (MUC1) [Golgi lumen]
T-antigen (MUC1) [Golgi lumen]
Sialyl Tn antigen (MUC1) [Golgi lumen]
GalNAc-MUC1(24-1255) [Golgi lumen]
Core 2a (MUC1) [Golgi lumen]
Core 2 (MUC1) [Golgi lumen]
GalNAc-MUC1(24-1255) [plasma membrane]
Inferred To
muc1 [Golgi lumen]
(Xenopus tropicalis)
Muc1 [Golgi lumen]
(Mus musculus)
Muc1 [Golgi lumen]
(Rattus norvegicus)
cnp-2 [Golgi lumen]
(Caenorhabditis elegans)
MUC1 [Golgi lumen]
(Bos taurus)
MUC1 [Golgi lumen]
(Canis familiaris)
MUC1 [Golgi lumen]
(Sus scrofa)
Modified Residues
Name
O-(N-acetylamino)galactosyl-L-serine (Neu5Ac-2,6(Neu5Ac-alpha2,3Gal-beta1,3)GalNAc-alpha group) at unknown position
Modification
Neu5Ac-2,6(Neu5Ac-alpha2,3Gal-beta1,3)GalNAc-alpha group
PsiMod Name
O-(N-acetylamino)galactosyl-L-serine
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-(N-acetylaminogalactosyl)-L-serine.
Cross References
RefSeq
NP_001191222.1
,
NP_001191216.1
,
NP_001191221.1
,
NP_001018016.1
,
NP_001191219.1
,
NP_001037855.1
,
NP_001191215.1
,
NP_001191223.1
,
NP_001018017.1
,
NP_002447.4
,
NP_001037856.1
,
NP_001191218.1
,
NP_001191214.1
,
NP_001191224.1
,
NP_001191217.1
,
NP_001037857.1
,
NP_001191226.1
,
NP_001191225.1
,
NP_001191220.1
,
NP_001037858.1
OpenTargets
ENSG00000185499
GeneCards
P15941
HPA
ENSG00000185499-MUC1
Ensembl
ENSP00000357381
,
ENST00000337604
,
ENSP00000342814
,
ENSP00000357383
,
ENSP00000339690
,
ENST00000368392
,
ENST00000368390
,
ENST00000368393
,
ENSP00000357378
,
ENST00000368396
,
ENSP00000357375
,
ENST00000342482
,
ENST00000368389
,
ENSP00000357374
,
ENST00000368398
,
ENST00000343256
,
ENSP00000357377
,
ENSG00000185499
,
ENSP00000338983
PRO
P15941
Pharos - Targets
P15941
Orphanet
21979
PDB
6FZQ
,
7Q4I
,
8P6I
,
2ACM
,
7V8Q
,
8AXH
,
7V4W
,
5T78
,
7V64
,
6KX1
,
7V7K
,
6TGG
,
6FZR
,
7VAC
,
7VAZ
,
2FO4
,
1SM3
,
5T6P
Interactors (4)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P00533 EGFR
20
p-6Y-EGFR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869138)
p-5Y-EGFRvIII [plasma membrane]
(R-HSA-1248649)
EGFRvIII [plasma membrane]
(R-HSA-1214162)
p-6Y-EGFR E746_A750del;T790M [plasma membrane]
(R-HSA-1182985)
p-6Y-EGFR L858R;T790M [plasma membrane]
(R-HSA-1182984)
p-6Y-EGFR A767_V769dup [plasma membrane]
(R-HSA-1996343)
p-6Y-EGFR N771_H773dup [plasma membrane]
(R-HSA-1996342)
p-6Y-EGFR K739_I744dup [plasma membrane]
(R-HSA-1996346)
p-6Y-EGFR D770_N771insNPG [plasma membrane]
(R-HSA-1996335)
p-6Y-EGFR E746_A750del [plasma membrane]
(R-HSA-1181214)
p-6Y-EGFR L858R [plasma membrane]
(R-HSA-1173211)
p-6Y-EGFR G719S [plasma membrane]
(R-HSA-1169417)
p-6Y-EGFR L747_P753delinsS [plasma membrane]
(R-HSA-1228038)
p-6Y-EGFR L747_A750delinsP [plasma membrane]
(R-HSA-1228044)
p-6Y-EGFR L747_T751del [plasma membrane]
(R-HSA-1228041)
p-6Y-EGFR L747_S752del [plasma membrane]
(R-HSA-1228040)
p-6Y-EGFR L747_T751delinsP [plasma membrane]
(R-HSA-1228042)
p-6Y-EGFR E746_T751delinsA [plasma membrane]
(R-HSA-1228037)
p-6Y-EGFR E746_S752delinsV [plasma membrane]
(R-HSA-1228039)
p-6Y-EGFR L861Q [plasma membrane]
(R-HSA-1177541)
0.819
6
UniProt:P12931 SRC
6
p-Y419-SRC [nucleoplasm]
(R-HSA-8937690)
SRC [cytosol]
(R-HSA-9628701)
p-Y419-SRC [cytosol]
(R-HSA-8964276)
MyrG-SRC [plasma membrane]
(R-HSA-8876922)
MyrG,p-Y530-SRC [plasma membrane]
(R-HSA-377598)
MyrG-p-Y419-SRC [plasma membrane]
(R-HSA-1810408)
0.748
5
UniProt:P26368 U2AF2
2
5OHK15,276-U2AF2 [nucleoplasm]
(R-HSA-9630011)
U2AF2 [nucleoplasm]
(R-HSA-71987)
0.471
2
UniProt:P00519 ABL1
6
p-Y393-ABL1 [cytosol]
(R-HSA-9865161)
p-Y226,Y393-ABL1 [nucleoplasm]
(R-HSA-8985251)
ABL1 [cytosol]
(R-HSA-375987)
p-Y226,Y393-ABL1 [cytosol]
(R-HSA-8942610)
ABL1 [nucleoplasm]
(R-HSA-5686579)
p-S456-ABL1 [nucleoplasm]
(R-HSA-5686576)
0.463
4
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