Reactome | SOCS6 [cytosol]

SOCS6 [cytosol]

Stable Identifier

R-HSA-1469969

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Suppressor of cytokine signaling 6, SOCS6_HUMAN

Locations in the PathwayBrowser

Expand all

Metabolism of proteins (Homo sapiens)

- Post-translational protein modification (Homo sapiens)
  - Neddylation (Homo sapiens)
    - AcM-UBE2F transfers NEDD8 to CRL5 E3 ubiquitin ligase complex (Homo sapiens)
      - NEDD8-AcM-UBE2F:CRL5 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Homo sapiens)
        
        CRL5 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Homo sapiens)
        
        CRL5 E3 ubiquitin ligase [cytosol] (Homo sapiens)
        
        CUL5-box protein [cytosol] (Homo sapiens)
        
        SOCS6 [cytosol] (Homo sapiens)
      - NEDD8-CRL5 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Homo sapiens)
        
        NEDD8-CRL5 E3 ligase [cytosol] (Homo sapiens)
        
        CUL5-box protein [cytosol] (Homo sapiens)
        
        SOCS6 [cytosol] (Homo sapiens)
    - CAND1 binds cytosolic CRL E3 ubiquitin ligases (Homo sapiens)
      - CRL E3 ubiquitin ligase:CAND1 [cytosol] (Homo sapiens)
        
        CRL E3 ubiquitin ligases [cytosol] (Homo sapiens)
        
        CRL5 E3 ubiquitin ligase [cytosol] (Homo sapiens)
        
        CUL5-box protein [cytosol] (Homo sapiens)
        
        SOCS6 [cytosol] (Homo sapiens)
      - CRL E3 ubiquitin ligases [cytosol] (Homo sapiens)
        
        CRL5 E3 ubiquitin ligase [cytosol] (Homo sapiens)
        
        CUL5-box protein [cytosol] (Homo sapiens)
        
        SOCS6 [cytosol] (Homo sapiens)
    - COMMDs displace CAND1 from cytosolic CRL E3 ubiquitin ligase complexes (Homo sapiens)
      - CRL E3 ubiquitin ligase:CAND1 [cytosol] (Homo sapiens)
        
        CRL E3 ubiquitin ligases [cytosol] (Homo sapiens)
        
        CRL5 E3 ubiquitin ligase [cytosol] (Homo sapiens)
        
        CUL5-box protein [cytosol] (Homo sapiens)
        
        SOCS6 [cytosol] (Homo sapiens)
      - CRL E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Homo sapiens)
        
        CRL5 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Homo sapiens)
        
        CRL5 E3 ubiquitin ligase [cytosol] (Homo sapiens)
        
        CUL5-box protein [cytosol] (Homo sapiens)
        
        SOCS6 [cytosol] (Homo sapiens)
    - COP9 signalosome deneddylates cytosolic CRL E3 ubiquitin ligase complexes (Homo sapiens)
      - CRL E3 ubiquitin ligase complex:COMMDs:CCDC22:DCUN1Ds [cytosol] (Homo sapiens)
        
        CRL5 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Homo sapiens)
        
        CRL5 E3 ubiquitin ligase [cytosol] (Homo sapiens)
        
        CUL5-box protein [cytosol] (Homo sapiens)
        
        SOCS6 [cytosol] (Homo sapiens)
      - NEDD8 CRL E3 ubiquitin ligases:COMMDs:CCDC22:DCUN1Ds [cytosol] (Homo sapiens)
        
        NEDD8-CRL5 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Homo sapiens)
        
        NEDD8-CRL5 E3 ligase [cytosol] (Homo sapiens)
        
        CUL5-box protein [cytosol] (Homo sapiens)
        
        SOCS6 [cytosol] (Homo sapiens)
    - NEDD8:AcM-UBE2F binds CRL5 E3 ubiquitin ligase complex (Homo sapiens)
      - CRL5 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Homo sapiens)
        
        CRL5 E3 ubiquitin ligase [cytosol] (Homo sapiens)
        
        CUL5-box protein [cytosol] (Homo sapiens)
        
        SOCS6 [cytosol] (Homo sapiens)
      - NEDD8-AcM-UBE2F:CRL5 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Homo sapiens)
        
        CRL5 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Homo sapiens)
        
        CRL5 E3 ubiquitin ligase [cytosol] (Homo sapiens)
        
        CUL5-box protein [cytosol] (Homo sapiens)
        
        SOCS6 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:O14544 SOCS6

Gene Names

SOCS6, CIS4, SOCS4

Chain

chain:1-535

Reference Genes

BioGPS Gene:9306 SOCS6

COSMIC (genes):SOCS4 SOCS6

COSMIC (genes):SOCS6 SOCS6

CTD Gene:9306 SOCS6

dbSNP Gene:9306 SOCS6

ENSEMBL:ENSG00000170677 SOCS6

HGNC:16833 SOCS6

KEGG:hsa:9306 SOCS6

Monarch:9306 SOCS6

NCBI Gene:9306 SOCS6

OMIM:605118 SOCS6

UCSC:O14544 SOCS6

Reference Transcript

Other Identifiers

11723362_s_at

11758088_s_at

16852997

206020_PM_at

206020_at

214462_PM_at

214462_at

227542_3p_at

227542_PM_at

227542_at

3384594

3384601

3792953

3792955

3792956

3792960

3792961

3792962

3792963

3792964

3792965

3792970

3792972

3792974

39957_at

39958_at

51848_at

8021707

9306

A_24_P91272

GE53145

GO:0001772

GO:0005515

GO:0005737

GO:0005829

GO:0005942

GO:0006629

GO:0006952

GO:0007259

GO:0009968

GO:0010498

GO:0016567

GO:0030163

GO:0035556

GO:0040008

GO:0046854

GO:0046935

GO:0050868

GO:0098772

HMNXSV003017499

Hs.57483.0.S1_3p_at

Hs.57483.0.S1_3p_s_at

Hs.57483.0.S1_3p_x_at

ILMN_1657077

PH_hs_0003227

PH_hs_0040174

TC18000242.hg

TC18000761.hg

g7705444_3p_at

Participates

as an input of

as a component of

as a candidate of

FLT3 ubiquitin ligases [cytosol] (Homo sapiens)

as a member of

CUL5-box protein [cytosol] (Homo sapiens)

Inferred To

Socs44A [cytosol] (Drosophila melanogaster)

SOCS6 [cytosol] (Bos taurus)

SOCS6 [cytosol] (Caenorhabditis elegans)

SOCS6 [cytosol] (Canis familiaris)

SOCS6 [cytosol] (Gallus gallus)

SOCS6 [cytosol] (Sus scrofa)

Socs6 [cytosol] (Mus musculus)

Socs6 [cytosol] (Rattus norvegicus)

socs6b [cytosol] (Danio rerio)

socs6 [cytosol] (Xenopus tropicalis)

Cross References

RefSeq

NP_004223.2, XP_016881575.1, XP_016881576.1, XP_005266840.1

OpenTargets

ENSG00000170677

ENSEMBL

ENST00000582322, ENSP00000463395, ENSP00000381034, ENST00000397942

HPA

ENSG00000170677-SOCS6

PRO

O14544

Pharos - Targets

O14544

GlyGen

O14544

PDB

2VIF

Interactors (21)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q93034 CUL5	2	CUL5 [cytosol] (R-HSA-180528) G76-NEDD8-K724-CUL5 [cytosol] (R-HSA-8952014)	0.643	7
UniProt:O95376 ARIH2	1	ARIH2 [cytosol] (R-HSA-975987)	0.623	3
UniProt:Q0VDC6 Q0VDC6			0.556	3
UniProt:Q13148 TADBP			0.556	3
UniProt:P54652 HSPA2	2	HSPA2 [cytosol] (R-HSA-3371408) HSPA2 [nucleoplasm] (R-HSA-912480)	0.556	3
UniProt:O60260-5 PRKN			0.556	3
UniProt:P42681 TXK	3	TXK [cytosol] (R-HSA-3448733) p-Y91,Y420-TXK [cytosol] (R-HSA-3448740) p-Y420-TXK [cytosol] (R-HSA-3448734)	0.556	3
UniProt:P49591 SARS1	1	SARS [cytosol] (R-HSA-379691)	0.556	3
UniProt:P06396 GSN	7	GSN [cytosol] (R-HSA-350275) GSN(28-403) [cytosol] (R-HSA-201618) GSN(404-782) [cytosol] (R-HSA-350272) GSN [secretory granule lumen] (R-HSA-6801486) GSN [extracellular region] (R-HSA-6806510) GSN [ficolin-1-rich granule lumen] (R-HSA-6801465) GSN(200-270) [extracellular region] (R-HSA-976940)	0.556	3
UniProt:P22607 FGFR3	20	FGFR3(23-760)-TACC3(612-838) fusion [plasma membrane] (R-HSA-8853144) FGFR3(23-760)-BAIAP2L1(18-522) fusion [plasma membrane] (R-HSA-8853131) FGFR3(23-793)-TACC3(143-838) fusion [plasma membrane] (R-HSA-8853152) FGFR3(23-758)-TACC3(549-838) fusion [plasma membrane] (R-HSA-8853124) FGFR3(23-758)-TACC3(649-838) fusion [plasma membrane] (R-HSA-8853125) FGFR3(23-760)-TACC3(647-838) fusion [plasma membrane] (R-HSA-8853127) FGFR3 K650T [plasma membrane] (R-HSA-1614411) FGFR3 K650N [plasma membrane] (R-HSA-1614406) FGFR3 K650M [plasma membrane] (R-HSA-1614402) FGFR3 K650Q [plasma membrane] (R-HSA-1614410) FGFR3 A391E [plasma membrane] (R-HSA-1614390) FGFR3 K650E [plasma membrane] (R-HSA-1614400) FGFR3 G380R [plasma membrane] (R-HSA-1614398) FGFR3 G382D [plasma membrane] (R-HSA-2018740) FGFR3 805fs*141 [plasma membrane] (R-HSA-1614387) p-6Y-FGFR3 A391E [plasma membrane] (R-HSA-2065835) p-6Y-FGFR3 K650T [plasma membrane] (R-HSA-2032966) p-6Y-FGFR3 G382D [plasma membrane] (R-HSA-2032950) p-6Y-FGFR3 G380R [plasma membrane] (R-HSA-2032946) p-6Y-FGFR3 K650M [plasma membrane] (R-HSA-2032959)	0.556	3
UniProt:Q9NX04 AIRIM			0.556	3
UniProt:O75460-2 ERN1			0.556	3
UniProt:Q9UMX0 UBQLN1	1	UBQLN1 [cytosol] (R-HSA-8866006)	0.556	3
UniProt:P00533 EGFR	20	p-6Y-EGFR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869138) p-5Y-EGFRvIII [plasma membrane] (R-HSA-1248649) EGFRvIII [plasma membrane] (R-HSA-1214162) p-6Y-EGFR E746_A750del;T790M [plasma membrane] (R-HSA-1182985) p-6Y-EGFR L858R;T790M [plasma membrane] (R-HSA-1182984) p-6Y-EGFR A767_V769dup [plasma membrane] (R-HSA-1996343) p-6Y-EGFR N771_H773dup [plasma membrane] (R-HSA-1996342) p-6Y-EGFR K739_I744dup [plasma membrane] (R-HSA-1996346) p-6Y-EGFR D770_N771insNPG [plasma membrane] (R-HSA-1996335) p-6Y-EGFR E746_A750del [plasma membrane] (R-HSA-1181214) p-6Y-EGFR L858R [plasma membrane] (R-HSA-1173211) p-6Y-EGFR G719S [plasma membrane] (R-HSA-1169417) p-6Y-EGFR L747_P753delinsS [plasma membrane] (R-HSA-1228038) p-6Y-EGFR L747_A750delinsP [plasma membrane] (R-HSA-1228044) p-6Y-EGFR L747_T751del [plasma membrane] (R-HSA-1228041) p-6Y-EGFR L747_S752del [plasma membrane] (R-HSA-1228040) p-6Y-EGFR L747_T751delinsP [plasma membrane] (R-HSA-1228042) p-6Y-EGFR E746_T751delinsA [plasma membrane] (R-HSA-1228037) p-6Y-EGFR E746_S752delinsV [plasma membrane] (R-HSA-1228039) p-6Y-EGFR L861Q [plasma membrane] (R-HSA-1177541)	0.553	2
UniProt:Q92569 PIK3R3	2	PIK3R3 [cytosol] (R-HSA-205223) K63polyUb-PIK3R3 [cytosol] (R-HSA-3080574)	0.547	2
UniProt:Q9H4B6 SAV1	2	p-SAV1 [cytosol] (R-HSA-2028276) SAV1 [cytosol] (R-HSA-2028283)	0.527	2
UniProt:P46937 YAP1	8	YAP1 [nucleoplasm] (R-HSA-1253322) YAP1 [cytosol] (R-HSA-1253345) p-S127-YAP1 [cytosol] (R-HSA-2028553) p-5S-YAP1 [cytosol] (R-HSA-2028554) p-Y-YAP1 [nucleoplasm] (R-HSA-8937857) p-Y-YAP1 [cytosol] (R-HSA-8937843) p-Y407-YAP1 [nucleoplasm] (R-HSA-8956661) p-Y407-YAP1 [cytosol] (R-HSA-9865208)	0.524	2
UniProt:Q7Z7G1 CLNK			0.488	2
UniProt:P46108-2 CRK			0.488	2
UniProt:Q9UKG1 APPL1	1	APPL1 [endosome membrane] (R-HSA-373630)	0.488	2
UniProt:Q8TBB1 LNX1	1	LNX1 [cytosol] (R-HSA-8851641)	0.488	2

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