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MIB2 [cytosol]
Stable Identifier
R-HSA-1472879
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
E3 ubiquitin-protein ligase MIB2, Mind bomb homolog 2
Locations in the PathwayBrowser
Expand all
Disease (Homo sapiens)
Diseases of signal transduction by growth factor receptors and second messengers (Homo sapiens)
Signaling by NOTCH1 in Cancer (Homo sapiens)
Signaling by NOTCH1 HD Domain Mutants in Cancer (Homo sapiens)
Constitutive Signaling by NOTCH1 HD Domain Mutants (Homo sapiens)
Ubiquitination of DLL/JAG ligands upon binding to NOTCH1 HD domain mutants (Homo sapiens)
MIB/NEURL [cytosol] (Homo sapiens)
MIB2 [cytosol] (Homo sapiens)
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer (Homo sapiens)
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants (Homo sapiens)
Ubiquitination of DLL/JAG ligands upon binding to NOTCH1 HD+PEST domain mutants (Homo sapiens)
MIB/NEURL [cytosol] (Homo sapiens)
MIB2 [cytosol] (Homo sapiens)
Signaling by NOTCH1 PEST Domain Mutants in Cancer (Homo sapiens)
Constitutive Signaling by NOTCH1 PEST Domain Mutants (Homo sapiens)
Ubiquitination of DLL/JAG ligands upon binding to NOTCH1 PEST domain mutants (Homo sapiens)
MIB/NEURL [cytosol] (Homo sapiens)
MIB2 [cytosol] (Homo sapiens)
Immune System (Homo sapiens)
Adaptive Immune System (Homo sapiens)
Class I MHC mediated antigen processing & presentation (Homo sapiens)
Antigen processing: Ubiquitination & Proteasome degradation (Homo sapiens)
Interaction of E3 with substrate and E2-Ub complex (Homo sapiens)
Ag-substrate:E3:E2:Ub [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
MIB2 [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
MIB2 [cytosol] (Homo sapiens)
Polyubiquitination of substrate (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
MIB2 [cytosol] (Homo sapiens)
E3:K48-polyubiquitinated substrate [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
MIB2 [cytosol] (Homo sapiens)
E3:Ub:substrate [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
MIB2 [cytosol] (Homo sapiens)
Release of E3 from polyubiquitinated substrate (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
MIB2 [cytosol] (Homo sapiens)
E3:K48-polyubiquitinated substrate [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
MIB2 [cytosol] (Homo sapiens)
Transfer of Ub from E2 to substrate and release of E2 (Homo sapiens)
Ag-substrate:E3:E2:Ub [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
MIB2 [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
MIB2 [cytosol] (Homo sapiens)
E3:Ub:substrate [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
MIB2 [cytosol] (Homo sapiens)
Signal Transduction (Homo sapiens)
Death Receptor Signaling (Homo sapiens)
TNF signaling (Homo sapiens)
Regulation of TNFR1 signaling (Homo sapiens)
MIB2 binds CFLAR (Homo sapiens)
CFLAR:MIB2:Ub:UBE2D1 [cytosol] (Homo sapiens)
MIB2 [cytosol] (Homo sapiens)
MIB2 [cytosol] (Homo sapiens)
MIB2 binds CYLD (Homo sapiens)
MIB2 [cytosol] (Homo sapiens)
MIB2:CYLD:UBE2D2 [cytosol] (Homo sapiens)
MIB2 [cytosol] (Homo sapiens)
MIB2 binds RIPK1 within TNF-α:TNFR1:TRADD:RIPK1:TRAF2 (Homo sapiens)
MIB2 [cytosol] (Homo sapiens)
TNF-α:TNFR1:TRADD:RIPK1:TRAF2:MIB2:Ub:UBE2D1 [plasma membrane] (Homo sapiens)
MIB2 [cytosol] (Homo sapiens)
MIB2 ubiquitinates CFLAR (Homo sapiens)
CFLAR:MIB2:Ub:UBE2D1 [cytosol] (Homo sapiens)
MIB2 [cytosol] (Homo sapiens)
MIB2 [cytosol] (Homo sapiens)
MIB2 ubiquitinates CYLD at K338, K530 (Homo sapiens)
MIB2 [cytosol] (Homo sapiens)
MIB2:CYLD:UBE2D2 [cytosol] (Homo sapiens)
MIB2 [cytosol] (Homo sapiens)
MIB2 ubiquitinates RIPK1 at K377, K604, K634 (Homo sapiens)
MIB2 [cytosol] (Homo sapiens)
TNF-α:TNFR1:TRADD:RIPK1:TRAF2:MIB2:Ub:UBE2D1 [plasma membrane] (Homo sapiens)
MIB2 [cytosol] (Homo sapiens)
TNF-α:TNFR1:TRADD:polyUb-RIPK1:TRAF2:MIB2 [plasma membrane] (Homo sapiens)
MIB2 [cytosol] (Homo sapiens)
TNFR1-induced proapoptotic signaling (Homo sapiens)
TRADD:TRAF2:RIP1 dissociates from TNF-α:TNFR1 (Homo sapiens)
MIB2 [cytosol] (Homo sapiens)
TNF-α:TNFR1:TRADD:polyUb-RIPK1:TRAF2:MIB2 [plasma membrane] (Homo sapiens)
MIB2 [cytosol] (Homo sapiens)
Signaling by NOTCH (Homo sapiens)
Signaling by NOTCH1 (Homo sapiens)
Activated NOTCH1 Transmits Signal to the Nucleus (Homo sapiens)
Ubiquitination of DLL/JAG ligands upon binding to NOTCH1 (Homo sapiens)
MIB/NEURL [cytosol] (Homo sapiens)
MIB2 [cytosol] (Homo sapiens)
Signaling by NOTCH2 (Homo sapiens)
NOTCH2 Activation and Transmission of Signal to the Nucleus (Homo sapiens)
Ubiquitination of DLL/JAG ligands upon binding to NOTCH2 (Homo sapiens)
MIB/NEURL [cytosol] (Homo sapiens)
MIB2 [cytosol] (Homo sapiens)
Signaling by NOTCH3 (Homo sapiens)
NOTCH3 Activation and Transmission of Signal to the Nucleus (Homo sapiens)
Ubiquitination of DLL/JAG ligands upon binding to NOTCH3 (Homo sapiens)
MIB/NEURL [cytosol] (Homo sapiens)
MIB2 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q96AX9 MIB2
Gene Names
MIB2, SKD, ZZANK1
Chain
chain:1-955
Reference Genes
BioGPS Gene:142678 MIB2
COSMIC (genes):MIB2 MIB2
CTD Gene:142678 MIB2
dbSNP Gene:142678 MIB2
ENSEMBL:ENSG00000197530 MIB2
HGNC:30577 MIB2
KEGG:hsa:142678 MIB2
Monarch:142678 MIB2
NCBI Gene:142678 MIB2
OMIM:611141 MIB2
UCSC:Q96AX9 MIB2
Reference Transcript
RefSeq:NM_001170688.1 MIB2
RefSeq:XM_011540741.2 MIB2
RefSeq:NM_001170689.1 MIB2
RefSeq:NM_001170687.1 MIB2
RefSeq:NM_001170686.1 MIB2
RefSeq:NM_080875.2 MIB2
Other Identifiers
11744135_a_at
142678
16657856
228261_PM_at
228261_at
2316100
2316101
2316102
2316103
241541_PM_at
241541_at
4042283
4042284
4042285
4042286
4042287
4042393
4042394
4042395
4042396
4042397
4042398
4042399
4042401
4042402
4042403
4042404
4042406
4042407
4042408
4042409
4042410
4042411
4042412
4042413
4042414
4042415
4042416
4042417
4042418
4042419
4042420
4042421
4042422
4042423
4042424
4042425
4042426
4042427
4042428
70785_at
7896985
89028_at
A_14_P110651
A_24_P259328
A_33_P3214925
A_33_P3308903
GE484786
GO:0000151
GO:0003779
GO:0003824
GO:0004842
GO:0005515
GO:0005737
GO:0005768
GO:0005769
GO:0005829
GO:0005886
GO:0007219
GO:0008092
GO:0008270
GO:0010803
GO:0016567
GO:0016740
GO:0031410
GO:0043123
GO:0043226
GO:0046872
GO:0061630
GO:0140096
HMNXSV003020916
HMNXSV003042906
Hs.135805.0.A1_3p_at
Hs.209424.0.A1_3p_at
Hs.209424.0.A1_3p_x_at
ILMN_1808107
ILMN_2282077
ILMN_2385178
PH_hs_0027849
TC01000046.hg
TC01004135.hg
Participates
as a component of
TNF-α:TNFR1:TRADD:RIPK1:TRAF2:MIB2:Ub:UBE2D1 [plasma membrane] (Homo sapiens)
MIB2:CYLD:UBE2D2 [cytosol] (Homo sapiens)
CFLAR:MIB2:Ub:UBE2D1 [cytosol] (Homo sapiens)
TNF-α:TNFR1:TRADD:polyUb-RIPK1:TRAF2:MIB2 [plasma membrane] (Homo sapiens)
as an input of
MIB2 binds RIPK1 within TNF-α:TNFR1:TRADD:RIPK1:TRAF2 (Homo sapiens)
MIB2 binds CYLD (Homo sapiens)
MIB2 binds CFLAR (Homo sapiens)
as an output of
MIB2 ubiquitinates CYLD at K338, K530 (Homo sapiens)
MIB2 ubiquitinates CFLAR (Homo sapiens)
as a member of
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
as a candidate of
MIB/NEURL [cytosol] (Homo sapiens)
Inferred To
mib2 [cytosol]
(Danio rerio)
mib2 [cytosol]
(Drosophila melanogaster)
mib2 [cytosol]
(Xenopus tropicalis)
MIB2 [cytosol]
(Bos taurus)
MIB2 [cytosol]
(Canis familiaris)
MIB2 [cytosol]
(Gallus gallus)
MIB2 [cytosol]
(Mus musculus)
MIB2 [cytosol]
(Rattus norvegicus)
MIB2 [cytosol]
(Sus scrofa)
mib-1 [cytosol]
(Caenorhabditis elegans)
Cross References
RefSeq
NP_001164157.1
,
NP_001164158.1
,
NP_001164159.1
,
XP_011539043.1
,
NP_001164160.1
,
NP_543151.2
ENSEMBL
ENST00000518681
,
ENST00000504599
,
ENST00000505820
,
ENST00000355826
,
ENSP00000367980
,
ENST00000378708
,
ENSG00000197530
,
ENSP00000426128
,
ENSP00000428264
,
ENST00000378712
,
ENSP00000428660
,
ENST00000520777
,
ENSP00000426103
,
ENSP00000348081
,
ENSP00000367984
OpenTargets
ENSG00000197530
GeneCards
MIB2
HPA
ENSG00000197530-MIB2
PRO
Q96AX9
Pharos - Targets
Q96AX9
Orphanet
MIB2
Interactors (1)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q9UHD2 TBK1
5
p-S172-TBK1 [cytosol]
(R-HSA-168379)
TBK1 [cytosol]
(R-HSA-166267)
K63polyUb-K30,K401-TBK1 [cytosol]
(R-HSA-9730430)
p-TBK1 [cytosol]
(R-HSA-9008705)
pS-172,K48polyUb-TBK1 [cytosol]
(R-HSA-3249397)
0.499
2
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