Reactome | DGCR8 [nucleoplasm]

DGCR8 [nucleoplasm]

Stable Identifier

R-HSA-1482509

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Microprocessor complex subunit DGCR8, DGCR8_HUMAN

Locations in the PathwayBrowser for interactor UniProt:Q9NWT1 PK1IP

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External Reference Information

External Reference

UniProt:Q8WYQ5 DGCR8

Gene Names

DGCR8, C22orf12, DGCRK6, LP4941

Chain

chain:1-773

Reference Genes

BioGPS Gene:54487 DGCR8

COSMIC (genes):DGCR8 DGCR8

CTD Gene:54487 DGCR8

dbSNP Gene:54487 DGCR8

ENSEMBL:ENSG00000128191 DGCR8

HGNC:2847 DGCR8

KEGG:hsa:54487 DGCR8

Monarch:54487 DGCR8

NCBI Gene:54487 DGCR8

OMIM:609030 DGCR8

UCSC:Q8WYQ5 DGCR8

Reference Transcript

Other Identifiers

11724329_a_at

11724330_s_at

16927174

218650_PM_at

218650_at

219811_PM_at

219811_at

3937184

3937185

3937186

3937189

3937190

3937191

3937192

3937193

3937194

3937195

3937196

3937197

3937198

3937199

3937201

3937202

3937203

3937204

3937205

3937210

3937211

3937212

3937213

3937214

3937215

3937216

3937217

3937218

3937219

3937220

3937221

3937222

3937223

3937227

50886_at

54487

64474_PM_g_at

64474_g_at

73323_s_at

8071314

91617_PM_at

91617_at

A_23_P211355

A_24_P113521

GE79852

GE82723

GE88044

GO:0003723

GO:0003725

GO:0005515

GO:0005634

GO:0005654

GO:0005730

GO:0005737

GO:0005829

GO:0006974

GO:0014069

GO:0016604

GO:0020037

GO:0030674

GO:0031053

GO:0035861

GO:0042802

GO:0042803

GO:0043226

GO:0046872

GO:0060090

GO:0070877

GO:0070878

GO:0072091

GO:0098978

GO:0140517

GO:2000633

HMNXSV003007791

HMNXSV003015783

HMNXSV003028916

ILMN_1694223

PH_hs_0034658

TC22000053.hg

g12225241_3p_at

g12225241_3p_x_at

g12232458_3p_s_at

Participates

as a component of

as an input of

MECP2 binds DGCR8 (Homo sapiens)

Cross References

OpenTargets

ENSG00000128191

ENSEMBL

ENSP00000384726, ENST00000351989, ENST00000407755, ENSP00000263209, ENSP00000409625, ENST00000457069

HPA

ENSG00000128191-DGCR8

PRO

Q8WYQ5

Pharos - Targets

Q8WYQ5

GlyGen

Q8WYQ5

PDB

6V5B, 2YT4, 3LE4, 7CNC, 6LXD, 5B16, 6LXE, 1X47, 6V5C

Interactors (45)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9NRR4 DROSHA	1	DROSHA [nucleoplasm] (R-HSA-1482510)	0.944	17
UniProt:Q96SB4 SRPK1	2	SRPK1 [nucleoplasm] (R-HSA-9821984) SRPK1 [cytosol] (R-HSA-9729349)	0.67	4
UniProt:Q8WYQ5 DGCR8	1	DGCR8 [nucleoplasm] (R-HSA-1482509)	0.59	2
UniProt:P50222 MEOX2			0.556	3
UniProt:Q92841 DDX17	2	monoSUMO1-K50-DDX17 [nucleoplasm] (R-HSA-3900104) DDX17 [nucleoplasm] (R-HSA-3900090)	0.499	2
UniProt:Q14692 BMS1	1	BMS1 [nucleoplasm] (R-HSA-6790720)	0.483	2
UniProt:P42696 RBM34			0.483	2
UniProt:Q9BQG0 MYBBP1A	1	MYBBP1A [nucleoplasm] (R-HSA-5250650)	0.483	2
UniProt:Q9NY61 AATF	1	AATF [cytosol] (R-HSA-205071)	0.483	2
UniProt:P46087 NOP2	1	NOP2 [nucleoplasm] (R-HSA-6790922)	0.483	2
UniProt:Q9NYV4 CDK12	1	CDK12 [nucleoplasm] (R-HSA-6797012)	0.483	2
UniProt:P62277 RPS13	2	RPS13 [cytosol] (R-HSA-72331) RPS13 [nucleoplasm] (R-HSA-6791198)	0.483	2
UniProt:Q12906 ILF3	3	ILF3 [nucleoplasm] (R-HSA-9760401) ILF3 [cytosol] (R-HSA-450564) p-T188,T315-ILF3 [cytosol] (R-HSA-9836381)	0.483	2
UniProt:Q9Y3T9 NOC2L	1	NOC2L [nucleoplasm] (R-HSA-3222129)	0.483	2
UniProt:Q5VYS8 ZCCHC6	1	TUT7 [cytosol] (R-HSA-8941313)	0.483	2
UniProt:O43159 RRP8	1	RRP8 [nucleoplasm] (R-HSA-427524)	0.483	3
UniProt:Q9NW13 RBM28	1	RBM28 [nucleoplasm] (R-HSA-6791192)	0.483	3
UniProt:Q8IY81 FTSJ3	1	FTSJ3 [nucleoplasm] (R-HSA-6791507)	0.483	3
UniProt:Q9BYG3 MK67I			0.483	3
UniProt:Q8NDF8 PAPD5			0.483	3
UniProt:Q96ME7 ZN512			0.483	2
UniProt:Q9NQ55 SSF1			0.483	2
UniProt:Q49A26 GLYR1			0.483	3
UniProt:Q13823 NOG2			0.483	3
UniProt:Q9H8H2 DDX31			0.483	3
UniProt:Q96GQ7 DDX27			0.483	3
UniProt:Q8TDN6 BRX1			0.483	2
UniProt:O15381 NVL			0.483	2
UniProt:Q03188 CENPC	2	CENPC [nucleoplasm] (R-HSA-5633512) CENPC1 [cytosol] (R-HSA-375292)	0.483	2
UniProt:O95793 STAU1			0.483	3
UniProt:Q9NWT1 PK1IP			0.483	2
UniProt:Q6PK04 CC137			0.483	3
UniProt:O75569 PRKRA	2	PRKRA [cytosol] (R-HSA-2399897) p-S246,S287-PRKRA [cytosol] (R-HSA-9834791)	0.483	2
UniProt:Q2TB10 ZN800			0.483	2
UniProt:Q15050 RRS1			0.483	2
UniProt:Q9NUL3 STAU2			0.483	2
UniProt:Q7Z2W4 ZC3HAV1	2	ZC3HAV1(2-624)-BRAF(439-766) fusion [cytosol] (R-HSA-6802506) ZC3HAV1(2-624)-p-BRAF(439-766) fusion [cytosol] (R-HSA-6802557)	0.483	3
UniProt:Q9Y388 RBMX2	1	RBMX2 [nucleoplasm] (R-HSA-9769535)	0.483	2
UniProt:O15226 NKRF			0.483	2
UniProt:Q9Y3C1 NOP16			0.483	3
UniProt:Q8WTT2 NOC3L			0.483	2
UniProt:Q9GZR2 REXO4			0.483	3
UniProt:Q9BXY0 MAK16			0.483	3
UniProt:Q9Y4C8 RBM19			0.483	2
UniProt:Q9NZM5 NOP53			0.483	2

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