Acyl chain remodeling of DAG and TAG

Stable Identifier
R-HSA-1482883
Type
Pathway
Species
Homo sapiens
ReviewStatus
5/5
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Acyl chain remodeling of DAG and TAG
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Acyl chain remodeling of triacylglycerol (TAG) and diacylglycerol (DAG) progresses through their hydrolysis by patatin-like phospholipase domain-containing proteins 2/3 (PNPLA2/3). DAG is reacylated back to TAG by acylglycerol O-acyltransferase 1/2 (DGAT1/2), while DAG and its hydrolysis product 2-monoacylglycerol (2-MAG) are transacylated back to TAG by PNPLA2/3. In addition, the DAG hydrolysis product 2-MAG is subsequently hydrolyzed to fatty acid and glycerol by monoglyceride lipase (MGLL) (Jenkins et al. 2004).
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Event Information
Go Biological Process
acylglycerol acyl-chain remodeling (0036155)
Orthologous Events
Acyl chain remodeling of DAG and TAG (Bos taurus)
Acyl chain remodeling of DAG and TAG (Caenorhabditis elegans)
Acyl chain remodeling of DAG and TAG (Canis familiaris)
Acyl chain remodeling of DAG and TAG (Danio rerio)
Acyl chain remodeling of DAG and TAG (Dictyostelium discoideum)
Acyl chain remodeling of DAG and TAG (Drosophila melanogaster)
Acyl chain remodeling of DAG and TAG (Gallus gallus)
Acyl chain remodeling of DAG and TAG (Mus musculus)
Acyl chain remodeling of DAG and TAG (Plasmodium falciparum)
Acyl chain remodeling of DAG and TAG (Rattus norvegicus)
Acyl chain remodeling of DAG and TAG (Saccharomyces cerevisiae)
Acyl chain remodeling of DAG and TAG (Schizosaccharomyces pombe)
Acyl chain remodeling of DAG and TAG (Sus scrofa)
Acyl chain remodeling of DAG and TAG (Xenopus tropicalis)
Authored
Williams, MG  (2011-09-14)
Reviewed
Wakelam, M  (2012-05-14)
Created
Williams, MG  (2011-08-12)
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