DAG is acylated to TAG by DGAT1/2

Stable Identifier
Reaction [transition]
Homo sapiens
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At the endoplasmic reticulum (ER) membrane, diacylglycerol (DAG) is acylated and forms triacylglycerol (TAG) by the action of diacylglycerol O-acyltransferase 1 (DGAT1) tetramer or by diacylglycerol O-acyltransferase 2 (DGAT2) (Wakimoto et al. 2003, Oelkers et al. 1998, Cases et al. 2001).

Literature References
PubMed ID Title Journal Year
14521909 A novel diacylglycerol acyltransferase (DGAT2) is decreased in human psoriatic skin and increased in diabetic mice

Wakimoto, K, Chiba, H, Michibata, H, Seishima, M, Kawasaki, S, Okubo, K, Mitsui, H, Torii, H, Imai, Y

Biochem Biophys Res Commun 2003
11481335 Cloning of DGAT2, a second mammalian diacylglycerol acyltransferase, and related family members

Cases, S, Stone, SJ, Zhou, P, Yen, E, Tow, B, Lardizabal, KD, Voelker, T, Farese, RV

J Biol Chem 2001
9756920 Characterization of two human genes encoding acyl coenzyme A:cholesterol acyltransferase-related enzymes

Oelkers, P, Behari, A, Cromley, D, Billheimer, JT, Sturley, SL

J Biol Chem 1998
Catalyst Activity

diacylglycerol O-acyltransferase activity of DGAT1/2 [endoplasmic reticulum membrane]

Orthologous Events
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