Reactome | Acyl chain remodelling of PI

Acyl chain remodelling of PI

Stable Identifier

R-HSA-1482922

Type

Pathway

Species

Homo sapiens

ReviewStatus

5/5

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In the acyl chain remodelling pathway (Lands cycle), phosphatidylinositol (PI) is hydrolyzed by phospholipases and subsequently reacylated by acyltransferases. These cycles modify the fatty acid composition of glycerophospholipids to generate diverse molecules asymmetrically distributed in the cell membrane (Ghomashchi et al. 2010, Singer et al. 2002, Gijon et al. 2008, Lee et al. 2008).

Literature References

PubMed ID	Title	Journal	Year
18772128	Lysophospholipid acyltransferases and arachidonate recycling in human neutrophils Zarini, S, Voelker, DR, Riekhof, WR, Gijon, MA, Murphy, RC	J Biol Chem	2008
20705608	Interfacial kinetic and binding properties of mammalian group IVB phospholipase A2 (cPLA2beta) and comparison with the other cPLA2 isoforms Lehr, M, Gelb, MH, Aloulou, A, Naika, GS, Bollinger, JG, Ghomashchi, F, Leslie, CC	J Biol Chem	2010
18094042	Caenorhabditis elegans mboa-7, a member of the MBOAT family, is required for selective incorporation of polyunsaturated fatty acids into phosphatidylinositol Kono, N, Matsuda, S, Mitani, S, Arai, H, Gengyo-Ando, K, Inoue, T, Lee, HC, Imae, R, Shirae, S	Mol Biol Cell	2008
12359733	Interfacial kinetic and binding properties of the complete set of human and mouse groups I, II, V, X, and XII secreted phospholipases A2 Gelb, MH, Le Calvez, C, Ghomashchi, F, Rouault, M, Singer, AG, Sadilek, M, Bollinger, J, Bezzine, S, Lambeau, G, Lazdunski, M, Nguyen, E	J Biol Chem	2002