Synthesis of CL

Stable Identifier
R-HSA-1483076
Type
Pathway
Species
Homo sapiens
ReviewStatus
5/5
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Synthesis of CL
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Cardiolipin(CL) is synthesized in the inner mitochondrial membrane, when phosphatidylglycerol (PG) and cytidine diphosphate-diacylglycerol (CDP-DAG) are converted into CL. In addition to be synthesized in mitochondria, CDP-DAG may also be imported from ER to serve as the cardiolipin precursor pool. PGP (phosphatidylglycerol phosphate) catalyzes rate limiting step of cardiolipin biosynthesis.
Literature References
PubMed ID Title Journal Year
16678169 Identification and characterization of human cardiolipin synthase

van Lenthe, H, Vaz, FM, Houtkooper, RH, Kulik, W, Akbari, H, Wanders, RJA, Frentzen, M

FEBS Lett 2006
16547353 Cloning and characterization of a cDNA encoding human cardiolipin synthase (hCLS1)

Hatch, GM, Feingold, KR, Lu, B, Grunfeld, C, Xu, FY, Jiang, YJ, Choy, PC

J Lipid Res 2006
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Event Information
Go Biological Process
cardiolipin biosynthetic process (0032049)
Orthologous Events
Synthesis of CL (Bos taurus)
Synthesis of CL (Caenorhabditis elegans)
Synthesis of CL (Danio rerio)
Synthesis of CL (Drosophila melanogaster)
Synthesis of CL (Gallus gallus)
Synthesis of CL (Mus musculus)
Synthesis of CL (Rattus norvegicus)
Synthesis of CL (Saccharomyces cerevisiae)
Synthesis of CL (Schizosaccharomyces pombe)
Synthesis of CL (Sus scrofa)
Authored
Williams, MG  (2011-09-14)
Created
Williams, MG  (2011-08-12)
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