Reactome | PE is methylated to PC by PEMT

PE is methylated to PC by PEMT

Stable Identifier

R-HSA-1483174

Type

Reaction [transition]

Species

Homo sapiens

Compartment

endoplasmic reticulum membrane, cytosol

ReviewStatus

5/5

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At the endoplasmic reticulum (ER) membrane, phosphatidylethanolamine N-methyltransferase (PEMT) methylates phosphatidylethanolamine (PE) and produces phosphatidylcholine (PC) (Vance & Ridgway 1998, Shields et al. 2001, Guan et al. 1999).

Literature References

PubMed ID	Title	Journal	Year
10100195	Activity of phosphatidylethanolamine-N-methyltransferase in brain affected by Alzheimer's disease Xiao, KQ, Guan, ZZ, Hu, PS, Wang, YN, Liu, JL	Neurochem Int	1999
11420179	Structure, expression profile and alternative processing of the human phosphatidylethanolamine N-methyltransferase (PEMT) gene Shields, DJ, Agellon, LB, Vance, DE	Biochim Biophys Acta	2001
3057511	The methylation of phosphatidylethanolamine Vance, DE, Ridgway, ND	Prog Lipid Res	1988