PC is converted to PS by PTDSS1

Stable Identifier
R-HSA-1483186
Type
Reaction [transition]
Species
Homo sapiens
Compartment
ReviewStatus
5/5
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At the endoplasmic reticulum (ER) membrane, phosphatidylserine synthase 1 (PTDSS1) converts phosphatidylcholine (PC) into phosphatidylserine (PS) by facilitating the exchange of L-Serine (L-Ser) with the choline (Cho) head group (Saito et al. 1998, Tomohiro et al. 2009).
Literature References
PubMed ID Title Journal Year
9642289 Genetic evidence that phosphatidylserine synthase II catalyzes the conversion of phosphatidylethanolamine to phosphatidylserine in Chinese hamster ovary cells

Saito, K, Kuge, O, Nishijima, M

J Biol Chem 1998
19014349 Purification and characterization of human phosphatidylserine synthases 1 and 2

Kawabe, Y, Kitada, S, Tomohiro, S, Kuge, O, Kawaguti, A

Biochem J 2009
Participants
Participates
Catalyst Activity

transferase activity of PTDSS1 [endoplasmic reticulum membrane]

Orthologous Events
Cross References
Rhea
Authored
Created
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