Synthesis of PC

Stable Identifier
R-HSA-1483191
Type
Pathway
Species
Homo sapiens
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Synthesis of PC
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De novo (Kennedy pathway) synthesis of phosphatidylcholine (PC) involves phosphorylation of choline (Cho) to phosphocholine (PCho) followed by condensing with cytidine triphosphate (CTP) to form CDP-choline (CDP-Cho). Diacylglycerol (DAG) and CDP-ETA together then form PC. Alternatively, PC is formed when phosphatidylethanolamine (PE) is methylated by phosphatidylethanolamine N-methyltransferase (PEMT) (Henneberry et al. 2002; Wright & McMaster 2002).

Literature References
Participants
Events
Participates
as an event of
Event Information
Go Biological Process
phosphatidylcholine biosynthetic process (0006656)
Orthologous Events
Synthesis of PC (Bos taurus)
Synthesis of PC (Caenorhabditis elegans)
Synthesis of PC (Canis familiaris)
Synthesis of PC (Danio rerio)
Synthesis of PC (Dictyostelium discoideum)
Synthesis of PC (Drosophila melanogaster)
Synthesis of PC (Gallus gallus)
Synthesis of PC (Mus musculus)
Synthesis of PC (Plasmodium falciparum)
Synthesis of PC (Rattus norvegicus)
Synthesis of PC (Saccharomyces cerevisiae)
Synthesis of PC (Schizosaccharomyces pombe)
Synthesis of PC (Sus scrofa)
Synthesis of PC (Xenopus tropicalis)
Cross References
GlyCosmos
Authored
Williams, MG  (2011-09-14)
Reviewed
Wakelam, M  (2012-05-14)
Created
Williams, MG  (2011-08-12)
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