Reactome | PA is dephosphorylated to DAG by LPIN

PA is dephosphorylated to DAG by LPIN

Stable Identifier

R-HSA-1483203

Type

Reaction [transition]

Species

Homo sapiens

Compartment

endoplasmic reticulum membrane, cytosol

ReviewStatus

5/5

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At the endoplasmic reticulum (ER) membrane, phosphatidate phosphatase 1-3 (LPIN) dephosphorylates phosphatidic acid (PA) to form diacylglycerol (DAG) (Grimsey et al. 2008, Donkor et al. 2007).

Literature References

PubMed ID	Title	Journal	Year
18694939	Temporal and spatial regulation of the phosphatidate phosphatases lipin 1 and 2 O'Hara, L, Rochford, JJ, Carman, GM, Grimsey, N, Siniossoglou, S, Han, GS	J Biol Chem	2008
17158099	Three mammalian lipins act as phosphatidate phosphatases with distinct tissue expression patterns Dewald, J, Reue, K, Donkor, J, Sariahmetoglu, M, Brindley, DN	J Biol Chem	2007