Reactome | PG transports from the ER membrane to the late endosome membrane

PG transports from the ER membrane to the late endosome membrane

Stable Identifier

R-HSA-1483218

Type

Reaction [transition]

Species

Homo sapiens

Compartment

endoplasmic reticulum membrane, late endosome membrane

ReviewStatus

5/5

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PG transports from the ER membrane to the late endosome membrane

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Lysobisphosphatidic acid, also known as bis(monoacylglycerol) hydrogen phosphate (BMP), is enriched in late endosomes and not found in the endoplasmic reticulum (ER) or mitochondria where phosphatidylglycerol (PG) is synthesised. Late endosomes form membrane contact sites with the ER, providing a means for PG to enter the late endosome and be converted to BMP (Levine 2004, Eden et al. 2010, Kobayashi et al. 1998, Hullin-Matsuda et al. 2007, Kobayashi et al. 1999).

Literature References

PubMed ID	Title	Journal	Year
15350976	Short-range intracellular trafficking of small molecules across endoplasmic reticulum junctions Levine, T	Trends Cell Biol	2004
20118922	Membrane contacts between endosomes and ER provide sites for PTP1B-epidermal growth factor receptor interaction White, IJ, Eden, ER, Futter, CE, Tsapara, A	Nat Cell Biol	2010
17558022	De novo biosynthesis of the late endosome lipid, bis(monoacylglycero)phosphate Lagarde, M, Schlame, M, Kobayashi, T, Xu, Y, Kawasaki, K, Hullin-Matsuda, F, Nishijima, M, Delton-Vandenbroucke, I	J Lipid Res	2007
10559883	Late endosomal membranes rich in lysobisphosphatidic acid regulate cholesterol transport Beuchat, MH, Gruenberg, J, Parton, RG, Lindsay, M, Kobayashi, T, Sakuraba, H, Palmiter, RD, Frias, S	Nat Cell Biol	1999
9515966	A lipid associated with the antiphospholipid syndrome regulates endosome structure and function Fang, KS, Gruenberg, J, Parton, RG, Kobayashi, T, de Moerloose, P, Stang, E	Nature	1998