Salvage - Sepiapterin is reduced to q-BH2

Stable Identifier
R-HSA-1497869
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
Synonyms
H(+) + NADPH + sepiapterin => L-erythro-7,8-dihydrobiopterin + NADP(+)
ReviewStatus
5/5
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Salvage - Sepiapterin is reduced to q-BH2
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In the first of two salvage steps to maintain BH4 levels in the cell, sepiapterin is taken up by the cell and reduced by sepiapterin reductase (SRP) to form BH2 (Sawabe et al. 2008).
Literature References
PubMed ID Title Journal Year
18511317 Cellular uptake of sepiapterin and push-pull accumulation of tetrahydrobiopterin

Sawabe, K, Yamamoto, K, Harada, Y, Ohashi, A, Sugawara, Y, Matsuoka, H, Hasegawa, H

Mol Genet Metab 2008
Participants
Input
Output
Participates
as an event of
Catalyst Activity

sepiapterin reductase (NADP+) activity of p-SPR dimer [cytosol]

Physical Entity
p-SPR dimer [cytosol] (Homo sapiens)
Activity
sepiapterin reductase (NADP+) activity (GO:0004757)
Orthologous Events
Salvage - Sepiapterin is reduced to q-BH2 (Bos taurus)
Salvage - Sepiapterin is reduced to q-BH2 (Canis familiaris)
Salvage - Sepiapterin is reduced to q-BH2 (Danio rerio)
Salvage - Sepiapterin is reduced to q-BH2 (Dictyostelium discoideum)
Salvage - Sepiapterin is reduced to q-BH2 (Drosophila melanogaster)
Salvage - Sepiapterin is reduced to q-BH2 (Gallus gallus)
Salvage - Sepiapterin is reduced to q-BH2 (Mus musculus)
Salvage - Sepiapterin is reduced to q-BH2 (Rattus norvegicus)
Salvage - Sepiapterin is reduced to q-BH2 (Sus scrofa)
Salvage - Sepiapterin is reduced to q-BH2 (Xenopus tropicalis)
Cross References
RHEA
Authored
Jassal, B  (2011-08-17)
Reviewed
D'Eustachio, P  (2011-08-23)
Created
Jassal, B  (2011-08-17)
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