Superoxide reacts rapidly with NO to form peroxynitrite (ONOO-)

Stable Identifier
R-HSA-1497878
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
Synonyms
nitric oxide + superoxide => peroxynitrite
ReviewStatus
5/5
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Superoxide reacts rapidly with NO to form peroxynitrite (ONOO-)
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Superoxide (O2.-) formed from an uncoupled eNOS action, together with nitric oxide (NO) formed from a coupled eNOS action, readily react together to fom peroxynitrite (ONOO-) (Jourd'heuil et al. 2001, Reiter et al. 2000).
Literature References
PubMed ID Title Journal Year
10906340 Superoxide reacts with nitric oxide to nitrate tyrosine at physiological pH via peroxynitrite

Reiter, CD, Teng, RJ, Beckman, JS

J Biol Chem 2000
11373284 Reaction of superoxide and nitric oxide with peroxynitrite. Implications for peroxynitrite-mediated oxidation reactions in vivo

Jourd'heuil, D, Jourd'heuil, FL, Kutchukian, PS, Musah, RA, Wink, DA, Grisham, MB

J Biol Chem 2001
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RHEA
Authored
Jassal, B  (2011-08-17)
Reviewed
D'Eustachio, P  (2011-08-23)
Created
Jassal, B  (2011-08-17)
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