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PLD2 [endoplasmic reticulum membrane]
Stable Identifier
R-HSA-1498791
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
endoplasmic reticulum membrane
Synonyms
Phospholipase D2
Locations in the PathwayBrowser
Expand all
Metabolism (Homo sapiens)
Metabolism of lipids (Homo sapiens)
Phospholipid metabolism (Homo sapiens)
Glycerophospholipid biosynthesis (Homo sapiens)
Synthesis of PA (Homo sapiens)
PC is hydrolyzed to PA and choline by PLD1/2 (Homo sapiens)
PLD1/2 [endoplasmic reticulum membrane] (Homo sapiens)
PLD2 [endoplasmic reticulum membrane] (Homo sapiens)
Synthesis of PG (Homo sapiens)
PC is transphosphatidylated to PG by PLD1-4/6 (Homo sapiens)
PLD1-4/6 [endoplasmic reticulum membrane] (Homo sapiens)
PLD2 [endoplasmic reticulum membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:O14939 PLD2
Gene Names
PLD2
Chain
chain:1-933
Reference Genes
BioGPS Gene:5338 PLD2
COSMIC (genes):PLD2 PLD2
CTD Gene:5338 PLD2
dbSNP Gene:5338 PLD2
ENSEMBL:ENSG00000129219 PLD2
HGNC:9068 PLD2
KEGG:hsa:5338 PLD2
Monarch:5338 PLD2
NCBI Gene:5338 PLD2
OMIM:602384 PLD2
UCSC:O14939 PLD2
Reference Transcript
RefSeq:NM_001243108.1 PLD2
RefSeq:NM_002663.4 PLD2
Other Identifiers
11748616_a_at
11757187_a_at
16829894
209643_PM_s_at
209643_s_at
3707218
3707219
3707220
3707221
3707222
3707223
3707224
3707225
3707226
3707227
3707228
3707229
3707230
3707231
3707232
3707233
3707234
3707235
3707236
3707237
3707238
3707239
3707240
3707241
3707242
3707243
3707244
3707245
3707246
3707247
3707248
3707249
3707250
3707252
3707253
3707254
3707255
3707256
3707257
41394_at
5338
8003962
A_23_P4308
A_33_P3286724
GE54324
GE81177
GO:0002376
GO:0003824
GO:0004630
GO:0005515
GO:0005789
GO:0005886
GO:0006629
GO:0006654
GO:0007010
GO:0007264
GO:0008289
GO:0009395
GO:0016042
GO:0016787
GO:0035091
GO:0035556
GO:0036465
GO:0038096
GO:0043226
GO:0043231
GO:0060627
GO:0098793
HMNXSV003008076
HMNXSV003033601
ILMN_1697880
PH_hs_0005797
TC17000053.hg
g2645857_3p_a_at
Participates
as a member of
PLD1-4/6 [endoplasmic reticulum membrane] (Homo sapiens)
PLD1/2 [endoplasmic reticulum membrane] (Homo sapiens)
Other forms of this molecule
PLD2 [plasma membrane]
Inferred To
PLD2 [endoplasmic reticulum membrane]
(Bos taurus)
PLD2 [endoplasmic reticulum membrane]
(Canis familiaris)
PLD2 [endoplasmic reticulum membrane]
(Sus scrofa)
Pld [endoplasmic reticulum membrane]
(Drosophila melanogaster)
Pld2 [endoplasmic reticulum membrane]
(Mus musculus)
Pld2 [endoplasmic reticulum membrane]
(Rattus norvegicus)
pld1 [endoplasmic reticulum membrane]
(Schizosaccharomyces pombe)
pld2 [endoplasmic reticulum membrane]
(Xenopus tropicalis)
pld-1 [endoplasmic reticulum membrane]
(Caenorhabditis elegans)
pldC [endoplasmic reticulum membrane]
(Dictyostelium discoideum)
SPO14 [endoplasmic reticulum membrane]
(Saccharomyces cerevisiae)
Cross References
RefSeq
NP_002654.3
,
NP_001230037.1
ZINC - World Drugs
PLD2_HUMAN
Guide to Pharmacology - Targets
1434
ENSEMBL
ENSP00000263088
,
ENST00000263088
,
ENST00000572940
,
ENSP00000459571
OpenTargets
ENSG00000129219
ZINC - FDA approved
PLD2_HUMAN
ZINC - Substances
PLD2_HUMAN
ZINC target
O14939
PRO
O14939
PDB
6OHS
,
7SVP
,
6OHM
,
6OHQ
,
6OHO
,
6OHP
HPA
ENSG00000129219-PLD2
Pharos - Targets
O14939
ZINC - Predictions - Purchasable
PLD2_HUMAN
HMDB Protein
HMDBP00080
Interactors (6)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P62993 GRB2
1
GRB2 [cytosol]
(R-HSA-8983328)
0.635
4
UniProt:P05067 APP
20
APP(672-713) [extracellular region]
(R-HSA-879340)
APP(672-711) [cytosol]
(R-HSA-877188)
APP(672-711) [extracellular region]
(R-HSA-976740)
APP [endoplasmic reticulum lumen]
(R-HSA-8956696)
p-APP [endoplasmic reticulum lumen]
(R-HSA-8957012)
APP(18-770) [endosome lumen]
(R-HSA-5229077)
APP(672-711) [endosome lumen]
(R-HSA-6783333)
APP(672-713) [endosome lumen]
(R-HSA-5692993)
APP(672-770) [endosome lumen]
(R-HSA-9010082)
APP(712-770) [endosome lumen]
(R-HSA-6783331)
APP(714-770) [endosome lumen]
(R-HSA-6783325)
APP(18-671) [endosome lumen]
(R-HSA-5693003)
APP(18-770) [plasma membrane]
(R-HSA-9010038)
APP(18-770) [Golgi lumen]
(R-HSA-8871509)
APP(688-770) [plasma membrane]
(R-HSA-9010028)
APP(18-687) [extracellular region]
(R-HSA-9010033)
APP(18-770) [platelet alpha granule lumen]
(R-HSA-139835)
APP(18-770) [extracellular region]
(R-HSA-49335)
APP-C99 [cytosol]
(R-HSA-9617603)
APP(18-770) [trans-Golgi network membrane]
(R-HSA-5229136)
0.556
3
UniProt:P23528 CFL1
3
CFL1 [cytosol]
(R-HSA-350751)
p-S3-CFL1 [cytosol]
(R-HSA-399813)
CFL1 [extracellular region]
(R-HSA-350747)
0.544
2
UniProt:P20309 CHRM3
1
CHRM3 [plasma membrane]
(R-HSA-399994)
0.527
2
UniProt:Q8TDQ0 HAVCR2
1
HAVCR2 [plasma membrane]
(R-HSA-5340408)
0.527
2
UniProt:P07437 TUBB
3
TUBB [extracellular region]
(R-HSA-380317)
TUBB [azurophil granule lumen]
(R-HSA-6799370)
TUBB [cytosol]
(R-HSA-9020816)
0.527
3
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