Reactome | PLD2 [endoplasmic reticulum membrane]

PLD2 [endoplasmic reticulum membrane]

Stable Identifier

R-HSA-1498791

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

endoplasmic reticulum membrane

Synonyms

Phospholipase D2

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:O14939 PLD2

Gene Names

PLD2

Chain

chain:1-933

Reference Genes

BioGPS Gene:5338 PLD2

COSMIC (genes):PLD2 PLD2

CTD Gene:5338 PLD2

dbSNP Gene:5338 PLD2

ENSEMBL:ENSG00000129219.14 PLD2

HGNC:9068 PLD2

KEGG Gene (Homo sapiens):5338 PLD2

Monarch:5338 PLD2

NCBI Gene:5338 PLD2

OMIM:602384 PLD2

UCSC:O14939 PLD2

Reference Transcript

Other Identifiers

11748616_a_at

11757187_a_at

16829894

209643_PM_s_at

209643_s_at

3707218

3707219

3707220

3707221

3707222

3707224

3707225

3707226

3707228

3707229

3707231

3707232

3707233

3707234

3707235

3707236

3707237

3707239

3707241

3707243

3707245

3707246

3707247

3707248

3707249

3707250

3707253

3707254

3707255

3707256

3707257

41394_at

5338

8003962

A_23_P4308

A_33_P3286724

GE54324

GE81177

GO:0002376

GO:0003824

GO:0004630

GO:0005515

GO:0005737

GO:0005783

GO:0005789

GO:0005886

GO:0006629

GO:0006654

GO:0007010

GO:0007264

GO:0008289

GO:0009395

GO:0012505

GO:0016020

GO:0016042

GO:0016192

GO:0016787

GO:0023052

GO:0035091

GO:0036465

GO:0038096

GO:0043226

GO:0043231

GO:0048017

GO:0060627

GO:0070290

GO:0098793

HMNXSV003008076

HMNXSV003033601

ILMN_1697880

PH_hs_0005797

TC17000053.hg

g2645857_3p_a_at

Participates

as a member of

Other forms of this molecule

PLD2 [plasma membrane]

Inferred To

PLD2 [endoplasmic reticulum membrane] (Bos taurus)

PLD2 [endoplasmic reticulum membrane] (Canis familiaris)

PLD2 [endoplasmic reticulum membrane] (Danio rerio)

PLD2 [endoplasmic reticulum membrane] (Dictyostelium discoideum)

PLD2 [endoplasmic reticulum membrane] (Sus scrofa)

Pld [endoplasmic reticulum membrane] (Drosophila melanogaster)

Pld2 [endoplasmic reticulum membrane] (Mus musculus)

Pld2 [endoplasmic reticulum membrane] (Rattus norvegicus)

pld1 [endoplasmic reticulum membrane] (Schizosaccharomyces pombe)

pld2 [endoplasmic reticulum membrane] (Xenopus tropicalis)

pld-1 [endoplasmic reticulum membrane] (Caenorhabditis elegans)

pldC [endoplasmic reticulum membrane] (Dictyostelium discoideum)

SPO14 [endoplasmic reticulum membrane] (Saccharomyces cerevisiae)

Homologues of PLD2 [endoplasmic reticulum membrane] (Danio rerio)

Homologues of PLD2 [endoplasmic reticulum membrane] (Dictyostelium discoideum)

pldA [endoplasmic reticulum membrane] (Dictyostelium discoideum)

Cross References

RefSeq

NP_001230037.1, NP_002654.3

ZINC - World Drugs

PLD2_HUMAN

Guide to Pharmacology - Targets

1434

OpenTargets

ENSG00000129219

ZINC - FDA approved

PLD2_HUMAN

ZINC - Substances

PLD2_HUMAN

ZINC target

O14939

PRO

O14939

PDB

6OHP, 6OHS, 6OHO, 6OHQ, 6OHM

IntEnz

3.1.4.4

HPA

ENSG00000129219-PLD2

GeneCards

O14939

Ensembl

ENSP00000263088, ENST00000572940, ENSG00000129219, ENST00000263088, ENSP00000459571

Pharos - Targets

O14939

ZINC - Predictions - Purchasable

PLD2_HUMAN

HMDB Protein

HMDBP00080

Interactors (3)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P62993 GRB2	1	GRB2 [cytosol] (R-HSA-8983328)	0.635	4
UniProt:P05067 APP	20	APP(18-770) [trans-Golgi network membrane] (R-HSA-5229136) APP-C99 [cytosol] (R-HSA-9617603) APP(18-687) [extracellular region] (R-HSA-9010033) APP(688-770) [plasma membrane] (R-HSA-9010028) APP(18-770) [Golgi lumen] (R-HSA-8871509) APP(18-770) [plasma membrane] (R-HSA-9010038) APP(18-671) [endosome lumen] (R-HSA-5693003) APP(714-770) [endosome lumen] (R-HSA-6783325) APP(712-770) [endosome lumen] (R-HSA-6783331) APP(672-770) [endosome lumen] (R-HSA-9010082) APP(672-713) [endosome lumen] (R-HSA-5692993) APP(672-711) [endosome lumen] (R-HSA-6783333) APP(18-770) [endosome lumen] (R-HSA-5229077) APP(18-770) [extracellular region] (R-HSA-49335) APP(18-770) [platelet alpha granule lumen] (R-HSA-139835) p-APP [endoplasmic reticulum lumen] (R-HSA-8957012) APP [endoplasmic reticulum lumen] (R-HSA-8956696) APP(672-711) [extracellular region] (R-HSA-976740) APP(672-711) [cytosol] (R-HSA-877188) APP(672-713) [extracellular region] (R-HSA-879340)	0.556	3
UniProt:P23528 CFL1	3	CFL1 [cytosol] (R-HSA-350751) p-S3-CFL1 [cytosol] (R-HSA-399813) CFL1 [extracellular region] (R-HSA-350747)	0.544	2

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