Reactome | FZD recruits DVL to the receptor complex

FZD recruits DVL to the receptor complex

Stable Identifier

R-HSA-1504188

Type

Reaction [binding]

Species

Homo sapiens

Compartment

plasma membrane, cytosol

ReviewStatus

5/5

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FZD recruits DVL to the receptor complex

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DVL is recruited to the plasma membrane through a direct interaction between its PDZ domain and a conserved motif of FZD located after the seventh transmembrane region. Recruitment of DVL to the receptor complex is thought to initiate recruitment of AXIN and GSK3beta (Fujii et al, 2007; Wong et al, 2003; Zeng et al, 2008; Tauriello et al, 2012).

Literature References

PubMed ID	Title	Journal	Year
18077588	Initiation of Wnt signaling: control of Wnt coreceptor Lrp6 phosphorylation/activation via frizzled, dishevelled and axin functions Almeida, K, Woodgett, J, Hsieh, JC, Harada, Y, Tamai, K, Huang, H, Wynshaw-Boris, A, Wang, J, Zhang, X, Doble, B, Yokota, C, Zeng, X, He, X	Development	2008
22411803	Wnt/?-catenin signaling requires interaction of the Dishevelled DEP domain and C terminus with a discontinuous motif in Frizzled Maurice, MM, Slootstra, JW, Kirchner, K, Bouwman, BA, Schambony, A, Noutsou, M, Schwamborn, K, Rüdiger, SG, Jordens, I, Tauriello, DV, Kruitwagen, T	Proc. Natl. Acad. Sci. U.S.A.	2012
17234765	An antagonist of dishevelled protein-protein interaction suppresses beta-catenin-dependent tumor cell growth Guy, RK, You, L, Zheng, J, He, B, Mikami, I, Jablons, DM, Shan, J, Neale, G, Uematsu, K, Edmondson, LR, Xu, Z, Fujii, N	Cancer Res	2007
14636582	Direct binding of the PDZ domain of Dishevelled to a conserved internal sequence in the C-terminal region of Frizzled Shi, DL, Zheng, J, Wu, D, Shao, Y, Wong, HC, Lee, HJ, Bourdelas, A, Mlodzik, M, Krauss, A	Mol Cell	2003