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ACHE [plasma membrane]
Stable Identifier
R-HSA-1524050
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
Acetylcholinesterase
Locations in the PathwayBrowser for interactor UniProt:P06733 ENO1
Expand all
Neuronal System (Homo sapiens)
Transmission across Chemical Synapses (Homo sapiens)
Neurotransmitter clearance (Homo sapiens)
ACHEIs bind ACHE (Homo sapiens)
ACHE [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:P22303 ACHE
Gene Names
ACHE
Chain
signal peptide:1-31, chain:32-614
Reference Genes
BioGPS Gene:43 ACHE
COSMIC (genes):ACHE ACHE
CTD Gene:43 ACHE
dbSNP Gene:43 ACHE
ENSEMBL:ENSG00000087085 ACHE
ENSEMBL_homo_sapiens_GENE:ENSG00000087085.16 ACHE
HGNC:108 ACHE
KEGG Gene (Homo sapiens):43 ACHE
Monarch:43 ACHE
NCBI Gene:43 ACHE
OMIM:100740 ACHE
UCSC:P22303 ACHE
Reference Transcript
RefSeq:NM_000665.4 ACHE
RefSeq:NM_015831.2 ACHE
RefSeq:XM_011516229.2 ACHE
RefSeq:NM_001282449.1 ACHE
RefSeq:XM_006715995.2 ACHE
RefSeq:NM_001302621.1 ACHE
RefSeq:NM_001302622.1 ACHE
RefSeq:XM_011516228.2 ACHE
Other Identifiers
11733279_a_at
11733280_a_at
17060791
205377_PM_s_at
205377_s_at
205378_PM_s_at
205378_s_at
3064357
3064358
3064359
3064360
3064362
3064363
3064364
3064365
3064366
3064367
3064369
3064370
3064371
3064372
3064374
3064375
3064376
3064377
3064378
3064379
3064380
40249_at
43
8141643
8141648
ADDON002502.hg
A_24_P60845
GE82034
GO:0001507
GO:0001540
GO:0001919
GO:0002076
GO:0003824
GO:0003990
GO:0004104
GO:0005515
GO:0005518
GO:0005576
GO:0005604
GO:0005615
GO:0005634
GO:0005794
GO:0005886
GO:0006581
GO:0007155
GO:0007399
GO:0007416
GO:0009986
GO:0016020
GO:0016192
GO:0016787
GO:0017171
GO:0023052
GO:0030154
GO:0030312
GO:0031012
GO:0031594
GO:0031623
GO:0032223
GO:0034330
GO:0042166
GO:0042802
GO:0042803
GO:0042982
GO:0043083
GO:0043226
GO:0043236
GO:0043621
GO:0045202
GO:0048471
GO:0048856
GO:0050714
GO:0052689
GO:0060041
GO:0095500
GO:0098552
GO:0120162
HMNXSV003013565
HMNXSV003053971
Hs.154495.0.S1_3p_a_at
Hs.157779.0.A1_3p_at
ILMN_1780485
ILMN_2333219
M55040_at
PH_hs_0009299
S71129_at
TC07001679.hg
TC07001680.hg
g7710111_3p_a_at
Participates
as an input of
ACHEIs bind ACHE (Homo sapiens)
as a component of
ACHE:ACHEIs [plasma membrane] (Homo sapiens)
as a member of
Cholinesterase [plasma membrane] (Homo sapiens)
Other forms of this molecule
ACHE [extracellular region]
Inferred To
cest-17 [plasma membrane]
(Caenorhabditis elegans)
cest-24 [plasma membrane]
(Caenorhabditis elegans)
cest-2.3 [plasma membrane]
(Caenorhabditis elegans)
cest-1.2 [plasma membrane]
(Caenorhabditis elegans)
ges-1 [plasma membrane]
(Caenorhabditis elegans)
Ghost homologue of ACHE [plasma membrane]
(Xenopus tropicalis)
ACHE [plasma membrane]
(Dictyostelium discoideum)
ACHE [plasma membrane]
(Gallus gallus)
ACHE [plasma membrane]
(Sus scrofa)
cest-2.1 [plasma membrane]
(Caenorhabditis elegans)
cest-2.2 [plasma membrane]
(Caenorhabditis elegans)
Est-6 [plasma membrane]
(Drosophila melanogaster)
D2 [plasma membrane]
(Dictyostelium discoideum)
ces2a [plasma membrane]
(Danio rerio)
GH05741 [plasma membrane]
(Drosophila melanogaster)
cest-12 [plasma membrane]
(Caenorhabditis elegans)
cryS [plasma membrane]
(Dictyostelium discoideum)
Est-P [plasma membrane]
(Drosophila melanogaster)
Homologues of ACHE [plasma membrane]
(Caenorhabditis elegans)
Homologues of ACHE [plasma membrane]
(Dictyostelium discoideum)
Homologues of ACHE [plasma membrane]
(Drosophila melanogaster)
Jhe [plasma membrane]
(Drosophila melanogaster)
Jhedup [plasma membrane]
(Drosophila melanogaster)
Dmel\CG4382 [plasma membrane]
(Drosophila melanogaster)
cest-13 [plasma membrane]
(Caenorhabditis elegans)
Dmel\CG12869 [plasma membrane]
(Drosophila melanogaster)
cest-1.1 [plasma membrane]
(Caenorhabditis elegans)
cest-16 [plasma membrane]
(Caenorhabditis elegans)
cest-19 [plasma membrane]
(Caenorhabditis elegans)
cest-26 [plasma membrane]
(Caenorhabditis elegans)
Cross References
RefSeq
NP_001269378.1
,
NP_056646.1
,
XP_011514530.1
,
NP_001289550.1
,
NP_000656.1
,
XP_011514531.1
,
XP_006716058.1
,
NP_001289551.1
ZINC - World Drugs
ACES_HUMAN
Guide to Pharmacology - Targets
2465
OpenTargets
ENSG00000087085
ZINC - FDA approved
ACES_HUMAN
ZINC - Substances
ACES_HUMAN
ZINC - Biogenic
ACES_HUMAN
ZINC target
P22303
PRO
P22303
PDB
4M0E
,
6U34
,
6WUV
,
5HF5
,
4PQE
,
6U37
,
1F8U
,
5HF6
,
2X8B
,
6WVQ
,
6NTH
,
4EY7
,
6O4X
,
6O50
,
4EY8
,
5HQ3
,
6NTK
,
6O66
,
4EY4
,
5FPQ
,
6O5V
,
4EY5
,
4EY6
,
6O69
,
3LII
,
6NEA
,
8DT7
,
6CQZ
,
8AEV
,
6O5S
,
7D9O
,
4M0F
,
6O5R
,
5FOQ
,
6CQW
,
6NTN
,
8AEN
,
6WVO
,
6CQV
,
8DT2
,
6NTM
,
1VZJ
,
6CQY
,
8DT5
,
6WVP
,
6CQX
,
6NTO
,
8DT4
,
6U3P
,
7RB5
,
6O4W
,
7XN1
,
6WVC
,
6O52
,
5HFA
,
6NTG
,
6F25
,
1B41
,
4BDT
,
6NTL
,
7RB7
,
7RB6
,
6CQT
,
6CQU
,
6WUY
,
7D9Q
,
5HF8
,
7E3D
,
5HF9
,
6WV1
,
7D9P
,
7E3H
,
6WUZ
,
6ZWE
ZINC - Investigational
ACES_HUMAN
ZINC - Metabolites
ACES_HUMAN
GeneCards
P22303
HPA
ENSG00000087085-ACHE
Ensembl
ENSP00000403474
,
ENST00000428317
,
ENSP00000414858
,
ENST00000419336
,
ENSP00000404865
,
ENSP00000241069
,
ENST00000411582
,
ENST00000241069
,
ENSG00000087085
,
ENST00000302913
,
ENST00000412389
,
ENSP00000303211
,
ENSP00000394976
Pharos - Targets
P22303
ZINC - Predictions - Purchasable
ACES_HUMAN
HMDB Protein
HMDBP00524
Interactors (3)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q9Y215 COLQ
0.558
2
UniProt:P63244 RACK1
1
GNB2L1 [cytosol]
(R-HSA-5626956)
0.527
2
UniProt:P06733 ENO1
1
ENO1 [cytosol]
(R-HSA-71437)
0.527
2
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