Phosphorylation of PLCgamma by PDGFR

Stable Identifier
R-HSA-1524186
Type
Reaction [transition]
Species
Homo sapiens
Compartment
ReviewStatus
5/5
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
The activated PDGF receptor phosphorylates PLCgamma on tyrosine residues 472,771,783 and 1254, activating the enzyme.
Literature References
PubMed ID Title Journal Year
2472219 Phospholipase C-gamma is a substrate for the PDGF and EGF receptor protein-tyrosine kinases in vivo and in vitro

Meisenhelder, J, Rhee, SG, Suh, PG, Hunter, T

Cell 1989
10579907 Phospholipase C-gamma as a signal-transducing element

Ji, Q, Carpenter, G

Exp Cell Res 1999
Participants
Participates
Catalyst Activity

protein tyrosine kinase activity of PDGF:Phospho-PDGF receptor dimer:PLC-gamma [plasma membrane]

Orthologous Events
Authored
Reviewed
Created
Cite Us!